CN1072723A - 三精氨酸胰岛素 - Google Patents
三精氨酸胰岛素 Download PDFInfo
- Publication number
- CN1072723A CN1072723A CN92113309A CN92113309A CN1072723A CN 1072723 A CN1072723 A CN 1072723A CN 92113309 A CN92113309 A CN 92113309A CN 92113309 A CN92113309 A CN 92113309A CN 1072723 A CN1072723 A CN 1072723A
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- CN
- China
- Prior art keywords
- tri
- arginine
- insulin
- human proinsulin
- proinsulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Inorganic materials [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US801,163 | 1985-11-22 | ||
| US80116391A | 1991-11-26 | 1991-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1072723A true CN1072723A (zh) | 1993-06-02 |
Family
ID=25180362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92113309A Pending CN1072723A (zh) | 1991-11-26 | 1992-11-25 | 三精氨酸胰岛素 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5491216A (https=) |
| EP (1) | EP0544466A1 (https=) |
| JP (1) | JP3304442B2 (https=) |
| KR (1) | KR930009591A (https=) |
| CN (1) | CN1072723A (https=) |
| AU (1) | AU2857692A (https=) |
| BR (1) | BR9204542A (https=) |
| CA (1) | CA2083360A1 (https=) |
| CZ (1) | CZ342492A3 (https=) |
| FI (1) | FI925343A7 (https=) |
| HU (2) | HUT63457A (https=) |
| IL (1) | IL103849A0 (https=) |
| MX (1) | MX9206724A (https=) |
| NO (1) | NO924525L (https=) |
| NZ (1) | NZ245170A (https=) |
| TW (1) | TW224471B (https=) |
| ZA (1) | ZA928916B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104017809A (zh) * | 2014-06-05 | 2014-09-03 | 山东省农业科学院生物技术研究中心 | 改造的人Insulin蛋白表达基因及表达方法 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0815136B1 (en) * | 1995-02-20 | 2007-06-13 | The Walter And Eliza Hall Institute Of Medical Research | Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (iddm) |
| PT821006E (pt) * | 1996-07-26 | 2004-09-30 | Aventis Pharma Gmbh | Derivados de insulina com ligacao a zinco aumentada |
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| DE60120372T2 (de) | 2000-03-24 | 2007-07-05 | Genentech Inc., San Francisco | Verwendung von insulin zur behandlung von knorpelkrankheiten |
| CZ2004710A3 (cs) * | 2001-12-20 | 2005-02-16 | Eli Lilly And Company | Inzulínová sloučenina s protrahovaným účinkem |
| EP1620465A2 (en) * | 2003-04-29 | 2006-02-01 | Eli Lilly And Company | Insulin analogs having protracted time action |
| WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| CN101573133B (zh) | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
| RU2524150C2 (ru) | 2006-09-22 | 2014-07-27 | Ново Нордиск А/С | Аналоги инсулина, устойчивые к протеазам |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| JP5496082B2 (ja) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー／エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| EP2296692A4 (en) * | 2008-04-22 | 2012-06-06 | Univ Case Western Reserve | ISOFORM-SPECIFIC INSULIN ANALOG |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| KR20120129875A (ko) * | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| AU2010327949A1 (en) | 2009-12-11 | 2012-06-28 | Case Western Reserve University | Insulin analogues with chlorinated amino acids |
| JP2014509603A (ja) * | 2011-03-15 | 2014-04-21 | ノヴォ ノルディスク アー／エス | システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体 |
| CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
| JP6499184B2 (ja) | 2013-10-07 | 2019-04-10 | ノヴォ ノルディスク アー／エス | インスリン類似体の新規な誘導体 |
| BR112017004544A2 (pt) | 2014-10-06 | 2018-01-23 | Univ Case Western Reserve | insulina de cadeia simples, composição farmacêutica e método para tratar diabetes mellitus |
| WO2016145389A1 (en) * | 2015-03-12 | 2016-09-15 | Board Of Trustees Of Michigan State University | Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases |
| KR20170036643A (ko) * | 2015-09-24 | 2017-04-03 | 한미약품 주식회사 | 인슐린의 제조 방법 |
| PE20210857A1 (es) | 2016-12-16 | 2021-05-18 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| US4569791A (en) * | 1984-06-14 | 1986-02-11 | Eli Lilly And Company | Anti-diabetic compounds |
| US4581165A (en) * | 1984-06-14 | 1986-04-08 | Eli Lilly And Company | Anti-diabetic compounds |
| US4569792A (en) * | 1984-06-14 | 1986-02-11 | Eli Lilly And Company | Anti-diabetic compounds |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| ZA877505B (en) * | 1986-10-14 | 1989-05-30 | Lilly Co Eli | Process for transforming a human insulin precursor to human insulin |
| US4992418A (en) * | 1987-07-17 | 1991-02-12 | Mount Sinai School Of Medicine | Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin |
| DE58906966D1 (de) * | 1988-06-23 | 1994-03-24 | Hoechst Ag | Mini-Proinsulin, seine Herstellung und Verwendung. |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5130236A (en) * | 1989-12-07 | 1992-07-14 | Eli Lilly And Company | Process for producing des(64,65)-proinsulin |
| US5139716A (en) * | 1990-02-20 | 1992-08-18 | Loral Aerospace Corp. | Method of fabricating coolable ceramic structures |
-
1992
- 1992-11-18 NZ NZ24517092A patent/NZ245170A/xx unknown
- 1992-11-18 TW TW081109247A patent/TW224471B/zh active
- 1992-11-18 CZ CS923424A patent/CZ342492A3/cs unknown
- 1992-11-18 ZA ZA928916A patent/ZA928916B/xx unknown
- 1992-11-19 CA CA002083360A patent/CA2083360A1/en not_active Abandoned
- 1992-11-20 EP EP92310616A patent/EP0544466A1/en not_active Withdrawn
- 1992-11-23 MX MX9206724A patent/MX9206724A/es unknown
- 1992-11-23 IL IL103849A patent/IL103849A0/xx unknown
- 1992-11-24 HU HU9203688A patent/HUT63457A/hu unknown
- 1992-11-24 AU AU28576/92A patent/AU2857692A/en not_active Abandoned
- 1992-11-24 KR KR1019920022175A patent/KR930009591A/ko not_active Withdrawn
- 1992-11-24 NO NO92924525A patent/NO924525L/no unknown
- 1992-11-24 HU HU9203688A patent/HU9203688D0/hu unknown
- 1992-11-25 BR BR9204542A patent/BR9204542A/pt not_active Application Discontinuation
- 1992-11-25 FI FI925343A patent/FI925343A7/fi not_active Application Discontinuation
- 1992-11-25 CN CN92113309A patent/CN1072723A/zh active Pending
- 1992-11-25 JP JP31483692A patent/JP3304442B2/ja not_active Expired - Fee Related
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1993
- 1993-07-06 US US08/087,831 patent/US5491216A/en not_active Expired - Fee Related
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1995
- 1995-06-06 US US08/466,945 patent/US5698669A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104017809A (zh) * | 2014-06-05 | 2014-09-03 | 山东省农业科学院生物技术研究中心 | 改造的人Insulin蛋白表达基因及表达方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CZ342492A3 (en) | 1993-06-16 |
| CA2083360A1 (en) | 1993-05-27 |
| HU9203688D0 (en) | 1993-03-29 |
| KR930009591A (ko) | 1993-06-21 |
| BR9204542A (pt) | 1993-06-01 |
| ZA928916B (en) | 1994-05-18 |
| NZ245170A (en) | 1994-07-26 |
| US5491216A (en) | 1996-02-13 |
| NO924525L (no) | 1993-05-27 |
| FI925343A0 (fi) | 1992-11-25 |
| HUT63457A (en) | 1993-08-30 |
| FI925343L (fi) | 1993-05-27 |
| FI925343A7 (fi) | 1993-05-27 |
| EP0544466A1 (en) | 1993-06-02 |
| NO924525D0 (no) | 1992-11-24 |
| IL103849A0 (en) | 1993-04-04 |
| MX9206724A (es) | 1993-05-01 |
| US5698669A (en) | 1997-12-16 |
| AU2857692A (en) | 1993-05-27 |
| TW224471B (https=) | 1994-06-01 |
| JP3304442B2 (ja) | 2002-07-22 |
| JPH05286998A (ja) | 1993-11-02 |
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