KR900701840A - 인슐린 유사체 - Google Patents
인슐린 유사체Info
- Publication number
- KR900701840A KR900701840A KR1019900700042A KR900700042A KR900701840A KR 900701840 A KR900701840 A KR 900701840A KR 1019900700042 A KR1019900700042 A KR 1019900700042A KR 900700042 A KR900700042 A KR 900700042A KR 900701840 A KR900701840 A KR 900701840A
- Authority
- KR
- South Korea
- Prior art keywords
- positions
- amino acid
- asn
- gln
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- Asn이 A18,A21 및 B3의 1 또는그 이상의 위치에 존재하지 않거나 및/ 또는 Gln이 A5,A15 및 B4의 1 또는 그 이상의 위치에 존재하지 않으며, 다한 A21위치의 아미노산 잔기가 Asn과 다를 때, A15,B4 또는 A5위치의 아미노산 잔기의 하나가 Gln과 다르거나 또는 A18 또는 B3위치의 아미노산 잔기의 하나가 Asn과 다르고, 그리고 다만 A5위치의 아미노산 잔기가 Gln과 다를 때 A15 또는 B4위치의 아미노산 잔기의 하나가 Gln과 다르거나 또는 A18,A21 또는 B3위치의 아미노산 잔기의 하나가 Asn과 다른 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 A18,A21 및 B3의 1 또는 그 이상의 위치에 존재하지 않거나 및/ 또는 Gln이 A15및/ 또는 B4위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 A18,A21 및 B3의 1 또는 그 이상의 위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 B3및 A18위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 B3및 A21위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 B3위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, Asn이 B3및 A21위치에 존재하지 않고 Gln이 A15위치에 존재하지 않는 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, A18,A21 또는 B3위치에서 1 또는 그 이상의 아미노산 잔기가Glu,Asp,His,Ser,Thr,Val,Leu,lle,Ala,Met,Trp,Tyr,Gly 또는 Gln이고 및/ 또는 A5,A15및 B4위치에서 1 또는 그 이상의 아미노산 잔기가 Glu,Asp.His,Ser,Thr,Val,Leu,Ile,Ala,Met,Trp,Tyr 또는 Gly인 것을 특징으로 하는 인슐린 유사체.
- 제1항에 있어서, B3위치의 아미노산 잔기가 Asp,Gln,Ser,Thr 또는 Glu인 것을 특징으로 하는 인슐린 유사체.
- 상기 항의 어느 한 항에 따른 인슐린 유사체 또는 그것의 약학적으로 허용되는 염을 함유하는 것을 특징으로 하는 인슐린 환성을 가지는 인슐린 제제.
- LysB29가 GlyA1에 펩티드 결합 또는 다음식(I)-Ra-R1- (I)의 펩티드 사슬에 의하여 연결된 인슐린 우사제의 전구제를 코드하는 DNA-서열을 구성된 복제가능한 발현 비히클로 형질전환된 이스트 균주를 적당한 배지에서 배양하고, 배양액으로 부터 전구체를 회수하여 다음식 (Ⅱ)Q-0R″ (Ⅱ)의 아미노 화합물과 반응시키고, 물 및 유기용매의 혼합물중에서 촉매로서 트립신 또는 트립신-유사효소를 사용하고 가수분해에 의해 카르복시 보호기를 제거하는 것을 특징으로 하는 제1항에 따른 인간 인슐린의 제조 방법.다만 상기 식 (I)에서 R은 n개의 아미노산 잔기를 가지는 펩티드 사슬이고 n은 O내지 33의 정수이고 R1은 Lys 또는 Arg이며, 상기 식 (Ⅱ)에서 Q는 B3O위치에 삽입되는 바람직하게는 Thr인 아미노산 잔기이고 R은 카르복시 보호기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK88,2579 | 1988-05-11 | ||
DK257988A DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Nye peptider |
PCT/DK1989/000117 WO1989010937A1 (en) | 1988-05-11 | 1989-05-10 | Insulin analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900701840A true KR900701840A (ko) | 1990-12-04 |
Family
ID=8113334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900700042A KR900701840A (ko) | 1988-05-11 | 1989-05-10 | 인슐린 유사체 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0419504B1 (ko) |
KR (1) | KR900701840A (ko) |
AU (1) | AU615760B2 (ko) |
DE (1) | DE68912777T2 (ko) |
DK (1) | DK257988D0 (ko) |
HU (1) | HUT55442A (ko) |
IE (1) | IE65504B1 (ko) |
NZ (1) | NZ229108A (ko) |
WO (1) | WO1989010937A1 (ko) |
ZA (1) | ZA893508B (ko) |
Families Citing this family (52)
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AU641631B2 (en) * | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
DK155690D0 (da) * | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
DK1265630T3 (da) | 2000-03-24 | 2006-10-09 | Genentech Inc | Anvendelse af insulin til behandling af brusksygdomme |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US7638618B2 (en) | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
US7202059B2 (en) | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
CA2621344C (en) | 2005-09-14 | 2014-12-16 | Sanofi-Aventis Deutschland Gmbh | Cleavage of precursors of insulins by a variant of trypsin |
BRPI0717098B8 (pt) | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
NZ586590A (en) * | 2008-01-09 | 2012-06-29 | Sanofi Aventis Deutschland | Insulin analogues or derivatives having an extremely delayed time-action profile |
WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
DE102008053048A1 (de) | 2008-10-24 | 2010-04-29 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
DE102009038210A1 (de) | 2009-08-20 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
DE102008051834A1 (de) | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
SI2451437T1 (sl) | 2009-07-06 | 2017-03-31 | Sanofi-Aventis Deutschlad Gmbh | Vodni pripravki, ki vsebujejo metionin |
US20120232002A1 (en) * | 2009-07-06 | 2012-09-13 | Sanofi-Aventis Deutschland Gmbh | Slow-acting insulin preparations |
EP2451472A1 (de) | 2009-07-06 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Hitze- und schüttelstabile insulinzubereitungen |
EP2459228B1 (en) | 2009-07-31 | 2020-03-04 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an insulin linker conjugate |
JP5732053B2 (ja) | 2009-07-31 | 2015-06-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 持続型インスリン組成物 |
AU2010317994B2 (en) | 2009-11-13 | 2014-03-06 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
US20140148384A1 (en) | 2010-08-30 | 2014-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
RU2014127270A (ru) | 2011-12-15 | 2016-02-10 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Аналог человеческого инсулина и его ацилированное производное |
US20130315891A1 (en) | 2012-05-25 | 2013-11-28 | Matthew Charles | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
DK2854841T3 (en) | 2012-06-04 | 2017-05-22 | Diamedica Inc | Kallikrein-1-glycosylation isoforms of human tissue |
NZ707160A (en) | 2012-12-19 | 2016-08-26 | Wockhardt Ltd | A stable aqueous composition comprising human insulin or an analogue or derivative thereof |
TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
WO2015044922A1 (en) | 2013-09-30 | 2015-04-02 | Wockhardt Limited | Pharmaceutical composition |
US9896496B2 (en) | 2013-10-07 | 2018-02-20 | Novo Nordisk A/S | Derivative of an insulin analogue |
JP6641280B2 (ja) | 2014-01-09 | 2020-02-05 | サノフイSanofi | インスリンアナログおよび/またはインスリン誘導体の安定化された医薬製剤 |
AU2015205621A1 (en) | 2014-01-09 | 2016-07-14 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
SG11201604706TA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized pharmaceutical formulations of insulin aspart |
WO2016001862A1 (en) | 2014-07-04 | 2016-01-07 | Wockhardt Limited | Extended release formulations of insulins |
EP3229828B1 (en) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
EP3260548A1 (en) | 2016-06-21 | 2017-12-27 | Enzypep B.V. | Enzymatic coupling of (oligo)peptides to the b-chain of an insulin receptor ligand |
WO2018109162A1 (en) | 2016-12-16 | 2018-06-21 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
CN110446501A (zh) | 2017-03-09 | 2019-11-12 | 代阿麦迪卡股份有限公司 | 组织激肽释放酶1的剂型 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2536040A1 (de) * | 1975-08-13 | 1977-02-24 | Hoechst Ag | Insulin-analoga mit biologischer wirkung |
NZ187300A (en) * | 1977-05-27 | 1982-08-17 | Univ California | Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism |
US4343898A (en) * | 1980-02-11 | 1982-08-10 | Novo Industri A/S | Process for preparing esters of human insulin |
IE62879B1 (en) * | 1987-02-25 | 1995-03-08 | Novo Nordisk As | Novel insulin derivatives |
-
1988
- 1988-05-11 DK DK257988A patent/DK257988D0/da not_active Application Discontinuation
-
1989
- 1989-05-10 KR KR1019900700042A patent/KR900701840A/ko not_active Application Discontinuation
- 1989-05-10 AU AU36928/89A patent/AU615760B2/en not_active Ceased
- 1989-05-10 HU HU893263A patent/HUT55442A/hu unknown
- 1989-05-10 DE DE89906057T patent/DE68912777T2/de not_active Expired - Fee Related
- 1989-05-10 EP EP89906057A patent/EP0419504B1/en not_active Expired - Lifetime
- 1989-05-10 WO PCT/DK1989/000117 patent/WO1989010937A1/en active IP Right Grant
- 1989-05-11 IE IE153689A patent/IE65504B1/en not_active IP Right Cessation
- 1989-05-11 ZA ZA893508A patent/ZA893508B/xx unknown
- 1989-05-12 NZ NZ229108A patent/NZ229108A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE65504B1 (en) | 1995-11-01 |
DE68912777T2 (de) | 1994-05-11 |
HU893263D0 (en) | 1991-03-28 |
DE68912777D1 (de) | 1994-03-10 |
IE891536L (en) | 1989-11-11 |
AU3692889A (en) | 1989-11-29 |
ZA893508B (en) | 1990-01-31 |
EP0419504A1 (en) | 1991-04-03 |
DK257988D0 (da) | 1988-05-11 |
NZ229108A (en) | 1992-05-26 |
EP0419504B1 (en) | 1994-01-26 |
WO1989010937A1 (en) | 1989-11-16 |
HUT55442A (en) | 1991-05-28 |
AU615760B2 (en) | 1991-10-10 |
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