KR850700246A - Crf 유사체 - Google Patents

Crf 유사체

Info

Publication number
KR850700246A
KR850700246A KR1019850700252A KR850700252A KR850700246A KR 850700246 A KR850700246 A KR 850700246A KR 1019850700252 A KR1019850700252 A KR 1019850700252A KR 850700252 A KR850700252 A KR 850700252A KR 850700246 A KR850700246 A KR 850700246A
Authority
KR
South Korea
Prior art keywords
leu
glu
ala
gln
arg
Prior art date
Application number
KR1019850700252A
Other languages
English (en)
Other versions
KR870000812B1 (ko
Inventor
캐서린 로르 리비어
Original Assignee
더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/583,092 external-priority patent/US4605642A/en
Priority claimed from US06/610,110 external-priority patent/US4594329A/en
Application filed by 더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈 filed Critical 더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈
Publication of KR850700246A publication Critical patent/KR850700246A/ko
Application granted granted Critical
Publication of KR870000812B1 publication Critical patent/KR870000812B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Details Of Television Scanning (AREA)
  • Amplifiers (AREA)
  • Control Of Eletrric Generators (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Vehicle Body Suspensions (AREA)

Abstract

내용 없음

Description

CRF 유사체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 한개 이상의 보호기를 가지며 하기 일반식(II)를 갖는 펩티드 또는 전술한 바와 같이 N-말단에서 잔기 몇개가 생략된 형태인 그의 변형체를 생성시키고, (b) 상기한 일반식(II)의 펩티드로부터 보호기 또는 보호기들 또는 고정결합을 분리시키고; (c) 필요에 따라, 생성된 펩티드를 그의 무독성 부가염으로 전환시키는 것으로 구성되는, 하기 일반식(I)의 화합물 또는 그의 무독성 부가염의 제조방법.
    (I) : Y-Q-leu-R11-R12-R13-leu-leu-Arg-R17-R18-R19-Glu-R21-R22-R23-R24-R25-R26-R27-R28-R29-Gln-ala-R32-R33-Asn-Agr-36-R37-R38-R39-R40-R41-NH2.
    (II) : X1-R1(X2)-R2(X4또는 X5)-R3(X5또는 X)-R4-R5-Ile-Ser(X2)-R8-R9(X5)-leu-R11(X2)-R12(X4)-R13(X Ehsms X5)-leu-leu-Arg(X3)-R17(X5또는 X6)-R18-R19(X4)-Glu(X5)-R21-R22(X2또는 X4)-R23(X3또는 X6)-R24(X4)-R25(X5)-R26(X4또는 X6)-R27(X4또는 X5)-R28(X3또는 X6)-R29(X4또는 X5)-Gln(X4)-Ala-R32(X)-R33(X2또는 X4)-Asn(X4)-Arg(X3)-R36(X6)-R37(X)-R38-R39(X5)-R40(X2또는 X4또는 X5)-R41(X4)-X7.
    상기식에서, Y는 탄소수 7이하인 아실기 또는 수소; Q는 R1-R2-R3-R4-R5-Ile-Ser-R8-R9또는 R8-R9또는 R8또는 R9또는 데스 Q; R1은 Ser, D-Ser 또는 데스 R1; R2는 Gln, pGlu, Glu, D-pGlu 또는 데스 R2; R3는 Glu, Gly, D-Tyr 또는 데스 R3; R4는 Pro, D-Pro 또는 데스 R4; R5는 Pro 또는 데스 R5; R8, R12, R19및 R24는 leu, Ile, ala, Gly, Val, Nle, Phe 및 Gln으로 구성되는 군에서 선택되고; R9은 Asp 또는 Glu; R11은 Thr 또는 Ser; R13은 His, Tyr 또는 Glu; R17은 Glu 또는 Lys; R18은 Val, Nle 또는 Met; R21은 Met, Nva, Ile, ala, leu, Nle, Val, Phe 또는 Gln ; R22은 ala, Thr, Asp 또는 Glu ; R23은 Arg, Orn, Har 또는 Lys ; R25는 Asp 또는 Glu ; R26은 Gln, Asn 또는 Lys ; R27은 leu, Ile, ala, Val, Nva, Met, Nle, Phe, Asp, Asn, Gln 또는 Glu ; R28은 ala, Arg 또는 Lys ; R29는 Gln 또는 Glu; R32는 His, Gly, Tyr 또는 ala; R33은 Ser, Asn, leu, Thr 또는 ala; R36은 Lys, Orn, Arg, Har 또는 Leu; R37은 leu 또는 Tyr; R38은 Met 또는 leu; R39는 Glu 또는 Asp; R40은 Ile, Thr, Glu, ala, Val, leu, Nle, Phe, Nva, Gly 또는 Gln; R41은 ala, Ile, Gly, Val, Leu, Nle, Phe, Gln 또는 데스 R41; (단, Q가 -Ile-Ser-을 함유할 경우 다음 사항 중 적어도 하나가 발생한다; R3는 D-Tyr, R4는 D-Pro, R28은 Arg, R29는 Glu, R26은 Arg이거나 Har, R37은 Tyr, 또는 R40은 Glu); X, X1, X2, X3, X4, X5및 X6는 각기 수소이거나 보호기이고, X7은 보호기이거나 또는 수지 지지체에 대한 고정결합 또는 NH2이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850700252A 1984-02-23 1985-02-21 Crf 유사체 KR870000812B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US583,092 1984-02-23
US06/583,092 US4605642A (en) 1984-02-23 1984-02-23 CRF antagonists
US06/610,110 US4594329A (en) 1984-05-14 1984-05-14 CRF analogs
US610,110 1984-05-14
PCT/US1985/000297 WO1985003705A1 (en) 1984-02-23 1985-02-21 Crf analogs

Publications (2)

Publication Number Publication Date
KR850700246A true KR850700246A (ko) 1985-12-26
KR870000812B1 KR870000812B1 (ko) 1987-04-20

Family

ID=27078728

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850700252A KR870000812B1 (ko) 1984-02-23 1985-02-21 Crf 유사체

Country Status (13)

Country Link
EP (2) EP0153845B1 (ko)
JP (1) JPH0742318B2 (ko)
KR (1) KR870000812B1 (ko)
AT (1) ATE88481T1 (ko)
AU (1) AU585500B2 (ko)
DE (1) DE3587276T2 (ko)
DK (1) DK172518B1 (ko)
ES (1) ES8606403A1 (ko)
FI (1) FI91413C (ko)
GR (1) GR850454B (ko)
IE (2) IE64241B1 (ko)
NO (1) NO171729C (ko)
WO (1) WO1985003705A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703340A1 (de) * 1987-02-04 1988-08-18 Dirck Dr Med Oppermann Pharmazeutische zubereitung zur behandlung der herzinsuffizienz
IE64788B1 (en) * 1988-06-21 1995-09-06 Salk Inst For Biological Studi CRF analogs
CA1341051C (en) * 1988-09-23 2000-07-11 Jean Edouard Frederic Rivier Crf antagonists
CA1340964C (en) * 1988-09-30 2000-04-18 Jean E. F. Rivier Crf analogs
CA2002004A1 (en) * 1988-11-14 1990-05-14 Karl P. Lederis Fish crf
US5235036A (en) * 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
WO1991014446A1 (en) * 1990-03-23 1991-10-03 The Salk Institute For Biological Studies Crf analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244946A (en) * 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
GR75679B (ko) * 1981-06-08 1984-08-02 Salk Inst For Biological Studi
US4415558A (en) * 1981-06-08 1983-11-15 The Salk Institute For Biological Studies CRF And analogs
US4385050A (en) * 1981-06-26 1983-05-24 Armour Pharmaceutical Company Antihypertensive polypeptides
EP0120000A1 (en) * 1982-09-29 1984-10-03 LEDERIS, Karl P. Urotensin peptides
US4489163A (en) * 1983-04-14 1984-12-18 The Salk Institute For Biological Studies rCRF and analogs
JPS59206342A (ja) * 1983-05-10 1984-11-22 Mitsubishi Chem Ind Ltd ペプチド類

Also Published As

Publication number Publication date
KR870000812B1 (ko) 1987-04-20
DE3587276T2 (de) 1993-07-29
FI854122L (fi) 1985-10-22
IE850452L (en) 1985-08-23
EP0518391A1 (en) 1992-12-16
FI91413C (fi) 1994-06-27
DE3587276D1 (de) 1993-05-27
AU585500B2 (en) 1989-06-22
WO1985003705A1 (en) 1985-08-29
NO854208L (no) 1985-12-20
IE64241B1 (en) 1995-07-26
FI91413B (fi) 1994-03-15
DK172518B1 (da) 1998-11-09
EP0153845A3 (en) 1988-09-07
FI854122A0 (fi) 1985-10-22
JPH0742318B2 (ja) 1995-05-10
DK486685A (da) 1985-10-23
GR850454B (ko) 1985-06-19
ATE88481T1 (de) 1993-05-15
IE940016L (en) 1985-08-23
AU4069385A (en) 1985-09-10
EP0153845B1 (en) 1993-04-21
DK486685D0 (da) 1985-10-23
ES8606403A1 (es) 1986-04-16
NO171729C (no) 1993-04-28
IE63601B1 (en) 1995-05-17
EP0153845A2 (en) 1985-09-04
NO171729B (no) 1993-01-18
ES540632A0 (es) 1986-04-16
JPS61502396A (ja) 1986-10-23

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