KR850008681A - 합성펩티드의 제조방법 - Google Patents
합성펩티드의 제조방법 Download PDFInfo
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- KR850008681A KR850008681A KR1019850003400A KR850003400A KR850008681A KR 850008681 A KR850008681 A KR 850008681A KR 1019850003400 A KR1019850003400 A KR 1019850003400A KR 850003400 A KR850003400 A KR 850003400A KR 850008681 A KR850008681 A KR 850008681A
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- KR
- South Korea
- Prior art keywords
- leu
- arg
- ala
- gln
- ser
- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 claims 7
- 125000006239 protecting group Chemical group 0.000 claims 5
- -1 Phe Chemical compound 0.000 claims 4
- XKCWNEVAXQCMGP-RXMQYKEDSA-N (2R)-2-amino-5-[carbamimidoyl(methyl)amino]pentanoic acid Chemical compound CN(CCC[C@@H](N)C(O)=O)C(N)=N XKCWNEVAXQCMGP-RXMQYKEDSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims 2
- SITWEMZOJNKJCH-WDSKDSINSA-N Ala-Arg Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SITWEMZOJNKJCH-WDSKDSINSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 claims 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- SITWEMZOJNKJCH-UHFFFAOYSA-N L-alanine-L-arginine Natural products CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N SITWEMZOJNKJCH-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Luminescent Compositions (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Dental Preparations (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- (a)적어도 하나의 보호기를 가지며 하기 구조(II)를 갖는 펩티드를 생성하고; (b)구조식(II)의 팹티드로부터 보호기 또는 보호기를 또는 고정결합을 분리시키고; (c)원한다면, 산출된 구조식(I)의 펩티드를 그의 무독성염을 제조하는 방법.
- (I):R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser-R10-Arg-R|12-R13-R14-R15-Gln-R17-R18-Ala-Arg-Lys-Leu-R23-R24-R25-Ile-R27-R28-R29-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39-R40-Arg-R42-R|43-R44.
- (II)X1-R1(X또는X2)R2-R3-(X3)Ala-Ile-Phe-Thr(X|4)-R8(X4또는X5)-Ser(X4)-R10-(X2)-Arg(X6)-R12(X6또는X|7)-R13-R14-R15-Gln(X5)-R17-R18-(X2)Ala-Arg(X6)-Lys(X7)-Leu-R23-R24)(X또는X5)-R52(X3)-Ile-R27-R28(X4또는X5)-R29(X6)-Cln(X5)-Cln(X5)-Gly-Glu-(X|3)-R34(X4또는X6)-Asn(X5)-Gln(X5)-Glu(X3)-R38(X5또는X6)-R39(X|6)-R40(X4)-Arg(X6)-R42-R43(X5또는X6)-R44(X8)-X9.
- 상기식에서, R1은 CαMe 또는 NαMe 치환체를 갖거나 또는 비치환된 Tyr, D-Tyr, Met, Phe, D-Phe, pCl-Phe, Leu, His 또는 D-His; R2는 Ala, D-Ala 또는 D-NMA; R3는 Asp 또는 D-Asp; R8는 Ser, Asn, - D-Ser 또는 D-Asn; R10는 Tyr 또는 D-Tyr; R12은 Arg 또는 Lys; R13는 Ile 또는 Val; R14은 Leu 또는 D-Leu; R15는 Gly 또는 D-Ala; R17는 Leu 또는 D-Leu ; R18은 Tyr 또는 Ser R23은 Leu 또는 D-Leu; R24은 His 또는 Gln; R25는 Glu, Asp, D-Glu 또는 D-Asp; R27는 Met, D-Met, Ala, Nle, Ile, Leu, Nva 또는 Val; R28은 Asn 또는 Ser; R29은 Arg 또는 D-Arg ; R34는 Arg 또는 Ser; R38는 Gln 또는 Arg; R39은 Arg 또는 Gly; R40는 Ser 또는 Ala; R42은 Phe,Ala 또는 Val; R43는 Asn 또는 Arg; R44는 천연 아미노산이고 [단 R28부터 R44까지 (R28과 R44를 포함하여)의 어느 잔기 또는 모두가 삭제될 수 있으며, 또한 R2가 D-NMA 및 / 또는 R14가 D-Leu 및 또는 R29가 D-Arg이다];
- X,X1,X2,X3,X4,X5,X6,X7및 X8는 각각 수소 또는 보호기이고, X9은 보호기이거나 혹은 수지지지체에 대한 고정결합, 또는 메스-X9인데 이 경우 C-말단에 있는 잔기는 Y로 정의된 바 있는 카르복시 성분을 갖는다.
- 제 1항에 있어서 R2가 D-NMA인 방법.
- 제1항 또는 제2항에 있어서, R29가 D-Arg인 방법.
- 제1항 내지 제3항중 어느 하나에 있어서, R14가 D-Leu인 방법.
- 제1항 내지 제4항중 어느 하나에 있어서, R25가 D-Glu인 방법
- 제1항 내지 제5항중 어느 하나에 있어서, R27이 Nle인 방법.
- 제1항 내지 제6항중 어느 하나에 있어서, R17이 D-Leu인 방법.
- 제1항 내지 제7항중 어느 하나에 있어서, R25가 D-Asp인 방법.
- 제1항 내지 제4항중 어느 하나에 있어서, R17이 D-Leu, R23이 D-Leu, R25가 Asp, R27이 Nle이고 잔기 30에서부터 44까지 삭제되는 방법.
- ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US611844 | 1984-05-18 | ||
| US06/611,844 US4528190A (en) | 1983-10-25 | 1984-05-18 | GRF Analogs IV |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850008681A true KR850008681A (ko) | 1985-12-21 |
| KR910000379B1 KR910000379B1 (ko) | 1991-01-24 |
Family
ID=24450622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850003400A KR910000379B1 (ko) | 1984-05-18 | 1985-05-17 | 합성 grt 펩티드 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4528190A (ko) |
| EP (1) | EP0161852B1 (ko) |
| JP (1) | JPH0689036B2 (ko) |
| KR (1) | KR910000379B1 (ko) |
| AT (1) | ATE73823T1 (ko) |
| AU (1) | AU578467B2 (ko) |
| CA (1) | CA1271299A (ko) |
| DD (1) | DD236536A5 (ko) |
| DE (1) | DE3585634D1 (ko) |
| DK (1) | DK162103C (ko) |
| EG (1) | EG17394A (ko) |
| ES (1) | ES8606412A1 (ko) |
| FI (1) | FI92210C (ko) |
| GR (1) | GR851207B (ko) |
| HU (1) | HU197759B (ko) |
| IE (1) | IE57813B1 (ko) |
| IL (1) | IL75088A (ko) |
| MX (1) | MX157381A (ko) |
| NO (1) | NO168043C (ko) |
| NZ (1) | NZ212113A (ko) |
| PH (1) | PH20976A (ko) |
| PT (1) | PT80450B (ko) |
| SU (1) | SU1530097A3 (ko) |
| YU (1) | YU46153B (ko) |
| ZA (1) | ZA852919B (ko) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| EP0193910A3 (en) * | 1985-03-06 | 1988-11-23 | Sumitomo Pharmaceuticals Company, Limited | Synthesis of a derivative of grf and intermediate peptides |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| DE3742633A1 (de) * | 1987-12-16 | 1989-06-29 | Hoechst Ag | Peptide mit beeinflussender wirkung auf die hypophyse von saeugern |
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| US4843064A (en) * | 1987-01-13 | 1989-06-27 | The Salk Institute For Biological Studies | GRF analogs V |
| IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| EP0289186A3 (en) * | 1987-04-23 | 1990-04-04 | International Minerals And Chemical Corporation | Process for increasing the growth rate and enhancing the feed efficiency of meat producing livestock |
| US5112808A (en) * | 1987-05-11 | 1992-05-12 | American Cyanamid Company | Alkylated hormone-releasing peptides and method of treatig mammals therewith |
| IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated peptides that release growth hormone and their use |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
| EP0307860B1 (en) * | 1987-09-18 | 1994-06-08 | F. Hoffmann-La Roche Ag | Cyclic GRF-analogs |
| AU637316B2 (en) * | 1988-01-28 | 1993-05-27 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| US5023322A (en) * | 1988-08-31 | 1991-06-11 | Mta Kutatas-Es Szervezetelemzo Intezete | Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| US5716937A (en) * | 1989-12-13 | 1998-02-10 | The General Hospital Corporation | Method for treating cardiac malfunction |
| CA2085362A1 (en) * | 1990-06-29 | 1991-12-30 | Arthur M. Felix | Histidine substituted growth hormone releasing factor analogs |
| DK0490249T3 (da) * | 1990-12-10 | 1995-05-29 | Hoffmann La Roche | Fremgangsmåde til enzymatisk fremstilling af GRF(1-44)-NH2 |
| CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
| ZA922746B (en) * | 1991-04-26 | 1992-12-30 | Lilly Co Eli | Superactive grf analogs |
| US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
| US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
| GB9324691D0 (en) * | 1993-12-01 | 1994-01-19 | Hafslund Nycomed As | Peptide compounds |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
| EP1355941A2 (en) * | 2001-02-02 | 2003-10-29 | ConjuChem, Inc. | Long lasting growth hormone releasing factor derivatives |
| JP2006504694A (ja) * | 2002-09-18 | 2006-02-09 | サントル・オスピタリエ・ドゥ・リュニヴェルシテ・ドゥ・モントリオール・（シー・エイチ・ユー・エム） | Ｇｈｒｈ類似体 |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
-
1984
- 1984-05-18 US US06/611,844 patent/US4528190A/en not_active Expired - Lifetime
-
1985
- 1985-04-18 ZA ZA852919A patent/ZA852919B/xx unknown
- 1985-04-26 DE DE8585302975T patent/DE3585634D1/de not_active Expired - Fee Related
- 1985-04-26 AT AT85302975T patent/ATE73823T1/de not_active IP Right Cessation
- 1985-04-26 EP EP85302975A patent/EP0161852B1/en not_active Expired - Lifetime
- 1985-04-29 IE IE1087/85A patent/IE57813B1/en not_active IP Right Cessation
- 1985-05-02 CA CA000480584A patent/CA1271299A/en not_active Expired - Fee Related
- 1985-05-03 IL IL75088A patent/IL75088A/xx not_active IP Right Cessation
- 1985-05-08 PH PH32242A patent/PH20976A/en unknown
- 1985-05-09 FI FI851842A patent/FI92210C/fi not_active IP Right Cessation
- 1985-05-10 YU YU77185A patent/YU46153B/sh unknown
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- 1985-05-15 AU AU42488/85A patent/AU578467B2/en not_active Ceased
- 1985-05-16 EG EG306/85A patent/EG17394A/xx active
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- 1985-05-17 ES ES543235A patent/ES8606412A1/es not_active Expired
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