KR840000477A - 헨테트 라콘타펩티드 crj 및 그 동족체와 관련된 펩티드류의 제조 방법 - Google Patents
헨테트 라콘타펩티드 crj 및 그 동족체와 관련된 펩티드류의 제조 방법 Download PDFInfo
- Publication number
- KR840000477A KR840000477A KR1019820002541A KR820002541A KR840000477A KR 840000477 A KR840000477 A KR 840000477A KR 1019820002541 A KR1019820002541 A KR 1019820002541A KR 820002541 A KR820002541 A KR 820002541A KR 840000477 A KR840000477 A KR 840000477A
- Authority
- KR
- South Korea
- Prior art keywords
- glu
- gln
- leu
- ala
- lys
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000006239 protecting group Chemical group 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 3
- 229920005990 polystyrene resin Polymers 0.000 claims 2
- HLPLTUJPJMFPMP-BYPYZUCNSA-N pyroglutamylglycine Chemical compound OC(=O)CNC(=O)[C@@H]1CCC(=O)N1 HLPLTUJPJMFPMP-BYPYZUCNSA-N 0.000 claims 2
- 108010041049 pyroglutamylglycine Proteins 0.000 claims 2
- OWOFCNWTMWOOJJ-WDSKDSINSA-N Gln-Glu Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(O)=O OWOFCNWTMWOOJJ-WDSKDSINSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- -1 R 8 is not He Chemical compound 0.000 claims 1
- ZOHGLPQGEHSLPD-FXQIFTODSA-N Ser-Gln-Glu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O ZOHGLPQGEHSLPD-FXQIFTODSA-N 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Polyesters Or Polycarbonates (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Developing Agents For Electrophotography (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Control Of Eletrric Generators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Vehicle Body Suspensions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- (a) 하기구조의 펩티드 중간체를 생성하고
- (b) 상기 폴리펩티드 중간체로부터 보호기 및 임의로 공유결합된 수지지지체를 제거하여 폴리펩티드를 얻고 생성된 폴리펩티드를 그의 무독성염으로 변화시키는 것으로 구성된 펩티드화합물의 제조 방법.
- X1-R1-Pro-Pro-Ile-Ser(X2)-R6-Asp(X5)-Leu-R11(X2)-R12-R13-Leu-Arg(X3)-R17-R18-R19-Glu(X5)-R21-R22-Lys(X6)-R24-R25-R26-R27-R28-Gln(X4)-Ala-R32-R33-Asn(X|4)-Arg(X3)-R36-Leu-Leu-Asp(X5)-R40-R41-X7
- 상기 구조에서
- R1은 Ser-Gln-Glu 또는 pGlu-Gly 또는 Gln-Glu 또는 Glu 또는 D-Ser-Gln-Glu 또는 D-pGlu-Gly 또는 des R1이며; R8,R12,R19,R24및 R40은 Leu,Ile,Ala,Gly,Val,Nle,Phe,Gln으로 구성된 군으로부터 선택되며; R11은 Thr 또는 Ser 이며; R13은 His,Tyr 또는 Glu이며; R17은 Glu 또는 Lys이며; R18은 Val 또는 Met이며; R21은 Met,Met(0),Ile,Ala,Leu,Gly,Nle,Val,Phe 또는 Gln이며; R22는 Thr 또는 Glu이며; R25는 Asp 또는 Glu이며; R26은 Gln 또는 Lys이며; R27은 Leu,Ile,Ala,Gly,Val,Nle,Phe,Asp,Asn,Gln 또는 Glu이며; R28은 Ala 또는 Lys이며; R32는 His,Tyr 또는 Ala이며; R33은 Ser,Asn,Thr 또는 Ala이며; R36은 Lys 또는 Len이며; R41은 Ala,Ile,Gly,Val,Leu,Nle,Phe,Gln 또는 des R41이며; 단 R13이 His 일때 R17은 Glu,R18은 Val,R22는 Thr,R26은 Gln,R28은 Ala,R36은 Lys이며, R13이 Glu,R17이 Lys,R18b이 Met,R22가 Glu,R26이 Lys,R32가 Ala이고 R36이 Leu 일때, R1이 pGlu-Gly이 아니거나 R8이 He이 아니거나 R11이 Thr 이거나 R12가 Leu이 아니거나 R|19가 He이 아니거나 R21이 He이 아니거나 R24가 Glu이 아니거나 R27이 Glu가 아니거나 R33이 Asn이 아니거나 R40이 Thr이 아니거나 또는 R41이 Ile이 아니어야 하며;
- X1은 수소 또는 α-아미노 보호기이며;
- X2는 수소 또는 Ser 또는 Thr 잔기의 알콜성 히드록실기 보호기이며;
- X3은 수소 또는 또는 Arg의 구아니디노기 보호기이며;
- X4는 수소 또는 Gln 또는 Asn의 아미도기 보호기이며;
- X5는 수소 또는 Asp 또는 Glu의 카복실기 보호기이며;
- X6는 수소 또는 Lys와 측쇄아미노기 보호기이며;
- X7은 OH,OCH3, 에스테르류, 아미드류, 히드라지드류, -0-CH2-, 폴리스티렌수지지지체 및-0-CH2-벤질-폴리스티렌 수지지지체이며, 단 X1-X7모두가 수소거나 OH 여서는 안된다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27162481A | 1981-06-08 | 1981-06-08 | |
| US271,624 | 1981-06-08 | ||
| US271624 | 1981-06-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840000477A true KR840000477A (ko) | 1984-02-22 |
| KR890002774B1 KR890002774B1 (ko) | 1989-07-28 |
Family
ID=23036364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8202541A KR890002774B1 (ko) | 1981-06-08 | 1982-06-07 | 헨테트라콘타펩티드 crf 및 그 동족체와 관련된 펩티드류의 제조방법 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0067608B1 (ko) |
| JP (1) | JPS57212149A (ko) |
| KR (1) | KR890002774B1 (ko) |
| AT (1) | ATE6505T1 (ko) |
| AU (1) | AU554676B2 (ko) |
| CA (1) | CA1243301A (ko) |
| DE (1) | DE3260057D1 (ko) |
| DK (1) | DK156957C (ko) |
| ES (1) | ES512892A0 (ko) |
| GR (1) | GR75679B (ko) |
| IE (1) | IE53488B1 (ko) |
| IL (1) | IL65937A (ko) |
| NZ (1) | NZ200711A (ko) |
| PH (1) | PH20364A (ko) |
| ZA (1) | ZA823635B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190081081A (ko) | 2017-12-29 | 2019-07-09 | (주)에스엠테크 | 디아민 화합물과 알루미네이트계 화합물을 포함하는 광물 미분쇄용 분쇄조제 조성물 및 이를 사용한 광물의 미분쇄방법 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE88481T1 (de) * | 1984-02-23 | 1993-05-15 | Salk Inst For Biological Studi | Crf-analoga. |
| CA1341051C (en) * | 1988-09-23 | 2000-07-11 | Jean Edouard Frederic Rivier | Crf antagonists |
| CA2002004A1 (en) * | 1988-11-14 | 1990-05-14 | Karl P. Lederis | Fish crf |
| US5235036A (en) * | 1991-05-31 | 1993-08-10 | The Salk Institute For Biological Studies | Crf analogs |
| DE4110422A1 (de) * | 1991-03-29 | 1992-10-01 | Bissendorf Peptide Gmbh | Arzneimittel enthaltend humanes corticotropin-releasing hormon (crh) und/oder dessen derivate und/oder glucocorticoide natuerlicher und/oder synthetischer provenienz |
| EP0781140A4 (en) * | 1994-09-12 | 1999-11-03 | Univ Pennsylvania | FACTOR INHIBITING THE CORTICOTROPIN RELEASE AND METHOD FOR ITS USE |
| US6039956A (en) * | 1994-09-12 | 2000-03-21 | Pennsylvania, Trustees Of The University Of, The | Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder |
| KR20200121309A (ko) | 2018-02-16 | 2020-10-23 | 제이엔씨 주식회사 | 중합성 화합물, 중합성 조성물, 중합체 및 포토레지스트용 조성물 |
-
1982
- 1982-01-04 GR GR68352A patent/GR75679B/el not_active IP Right Cessation
- 1982-05-24 NZ NZ200711A patent/NZ200711A/en unknown
- 1982-05-25 ZA ZA823635A patent/ZA823635B/xx unknown
- 1982-05-26 PH PH27349A patent/PH20364A/en unknown
- 1982-06-01 CA CA000404182A patent/CA1243301A/en not_active Expired
- 1982-06-01 EP EP82302812A patent/EP0067608B1/en not_active Expired
- 1982-06-01 AT AT82302812T patent/ATE6505T1/de not_active IP Right Cessation
- 1982-06-01 DE DE8282302812T patent/DE3260057D1/de not_active Expired
- 1982-06-01 IL IL65937A patent/IL65937A/xx not_active IP Right Cessation
- 1982-06-02 IE IE1330/82A patent/IE53488B1/en unknown
- 1982-06-03 AU AU84455/82A patent/AU554676B2/en not_active Ceased
- 1982-06-07 DK DK254982A patent/DK156957C/da not_active IP Right Cessation
- 1982-06-07 ES ES512892A patent/ES512892A0/es active Granted
- 1982-06-07 KR KR8202541A patent/KR890002774B1/ko active
- 1982-06-08 JP JP57098388A patent/JPS57212149A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190081081A (ko) | 2017-12-29 | 2019-07-09 | (주)에스엠테크 | 디아민 화합물과 알루미네이트계 화합물을 포함하는 광물 미분쇄용 분쇄조제 조성물 및 이를 사용한 광물의 미분쇄방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57212149A (en) | 1982-12-27 |
| PH20364A (en) | 1986-12-04 |
| IE821330L (en) | 1982-12-08 |
| AU8445582A (en) | 1982-12-16 |
| CA1243301A (en) | 1988-10-18 |
| EP0067608A1 (en) | 1982-12-22 |
| EP0067608B1 (en) | 1984-03-07 |
| AU554676B2 (en) | 1986-08-28 |
| DE3260057D1 (en) | 1984-04-12 |
| DK254982A (da) | 1982-12-09 |
| ES8401446A1 (es) | 1983-12-01 |
| ES512892A0 (es) | 1983-12-01 |
| DK156957C (da) | 1990-03-19 |
| IE53488B1 (en) | 1988-11-23 |
| GR75679B (ko) | 1984-08-02 |
| ATE6505T1 (de) | 1984-03-15 |
| KR890002774B1 (ko) | 1989-07-28 |
| IL65937A0 (en) | 1982-09-30 |
| ZA823635B (en) | 1983-03-30 |
| JPS642600B2 (ko) | 1989-01-18 |
| IL65937A (en) | 1986-09-30 |
| DK156957B (da) | 1989-10-23 |
| NZ200711A (en) | 1986-02-21 |
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