ES8606403A1 - Un procedimiento de preparar peptidos. - Google Patents

Un procedimiento de preparar peptidos.

Info

Publication number
ES8606403A1
ES8606403A1 ES540632A ES540632A ES8606403A1 ES 8606403 A1 ES8606403 A1 ES 8606403A1 ES 540632 A ES540632 A ES 540632A ES 540632 A ES540632 A ES 540632A ES 8606403 A1 ES8606403 A1 ES 8606403A1
Authority
ES
Spain
Prior art keywords
beta
administered
pharmaceutically
veterinarily acceptable
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540632A
Other languages
English (en)
Other versions
ES540632A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/583,092 external-priority patent/US4605642A/en
Priority claimed from US06/610,110 external-priority patent/US4594329A/en
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES540632A0 publication Critical patent/ES540632A0/es
Publication of ES8606403A1 publication Critical patent/ES8606403A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Steroid Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Details Of Television Scanning (AREA)
  • Amplifiers (AREA)
  • Control Of Eletrric Generators (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Vehicle Body Suspensions (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR NUEVOS PEPTIDOS. COMPRENDE: A) COPULAR A LOS AMINOACIDOS PROTEGIDOS CON (BOC) EN CLORURO DE METILENO A UNA (A), PARA PRODUCIR UN PEPTIDO D.F (II); Y B) TRATAR A (II) SUCESIVAMENTE CON ACIDO TRIFLUOROACETICO, EN CL2CH2, CON FH Y CON ANISOL, ENTRE C20 Y 0JC, PARA ESCINDIR SUS GRUPOS PROTECTORES Y OBTENER UN C.D.F (I) Y SUS SALES NO TOXICAS. SIENDO: A UNA RESINA CON UN SOPORTE (B); (B) -NH-BENZIHIDRILAMINA; (BOC) TERC-BUTILOXICARBONILO; X1, X2, X3, X4, X5, X6, H O GRUPOS PROTECTORES AMINOS, AMIDOS Y CARBOXILOS; X8 -O-CH2-(B); Y ACILO DE C 1 A 7; Q RADICAL D.F (III) O (IV); R1 Y R33SER Y OTROS; R2, R26 Y R29,GLN Y OTROS; R3, R17 Y R39GLU Y OTROS; R4 Y R5 PRO Y OTROS; R8, R12, R19, R24, Y R27LEU, ILE Y OTROS; R9 Y R25, ASP Y OTROS; R11 THR Y OTROS; R13 Y R22, HIS Y OTROS; R18 VAL Y OTROS; R21 Y R38 MET Y OTROS; R22, R28 Y R41, ALA Y OTROS; R23ARG Y OTROS; R36 LYS Y OTROS; R37 LEU Y OTROS; Y R40 ILE Y OTROS.
ES540632A 1984-02-23 1985-02-22 Un procedimiento de preparar peptidos. Expired ES8606403A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/583,092 US4605642A (en) 1984-02-23 1984-02-23 CRF antagonists
US06/610,110 US4594329A (en) 1984-05-14 1984-05-14 CRF analogs

Publications (2)

Publication Number Publication Date
ES540632A0 ES540632A0 (es) 1986-04-16
ES8606403A1 true ES8606403A1 (es) 1986-04-16

Family

ID=27078728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540632A Expired ES8606403A1 (es) 1984-02-23 1985-02-22 Un procedimiento de preparar peptidos.

Country Status (13)

Country Link
EP (2) EP0518391A1 (es)
JP (1) JPH0742318B2 (es)
KR (1) KR870000812B1 (es)
AT (1) ATE88481T1 (es)
AU (1) AU585500B2 (es)
DE (1) DE3587276T2 (es)
DK (1) DK172518B1 (es)
ES (1) ES8606403A1 (es)
FI (1) FI91413C (es)
GR (1) GR850454B (es)
IE (2) IE63601B1 (es)
NO (1) NO171729C (es)
WO (1) WO1985003705A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703340A1 (de) * 1987-02-04 1988-08-18 Dirck Dr Med Oppermann Pharmazeutische zubereitung zur behandlung der herzinsuffizienz
IE64788B1 (en) * 1988-06-21 1995-09-06 Salk Inst For Biological Studi CRF analogs
CA1341051C (en) * 1988-09-23 2000-07-11 Jean Edouard Frederic Rivier Crf antagonists
CA1340964C (en) * 1988-09-30 2000-04-18 Jean E. F. Rivier Crf analogs
CA2002004A1 (en) * 1988-11-14 1990-05-14 Karl P. Lederis Fish crf
ATE169639T1 (de) * 1990-03-23 1998-08-15 Salk Inst For Biological Studi Crf-analoge
US5235036A (en) * 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244946A (en) * 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
GR75679B (es) * 1981-06-08 1984-08-02 Salk Inst For Biological Studi
US4415558A (en) * 1981-06-08 1983-11-15 The Salk Institute For Biological Studies CRF And analogs
US4385050A (en) * 1981-06-26 1983-05-24 Armour Pharmaceutical Company Antihypertensive polypeptides
WO1984001378A1 (en) * 1982-09-29 1984-04-12 Karl P Lederis Urotensin peptides
US4489163A (en) * 1983-04-14 1984-12-18 The Salk Institute For Biological Studies rCRF and analogs
JPS59206342A (ja) * 1983-05-10 1984-11-22 Mitsubishi Chem Ind Ltd ペプチド類

Also Published As

Publication number Publication date
IE850452L (en) 1985-08-23
ATE88481T1 (de) 1993-05-15
AU585500B2 (en) 1989-06-22
AU4069385A (en) 1985-09-10
NO171729C (no) 1993-04-28
IE64241B1 (en) 1995-07-26
FI854122L (fi) 1985-10-22
ES540632A0 (es) 1986-04-16
DK172518B1 (da) 1998-11-09
DE3587276D1 (de) 1993-05-27
NO854208L (no) 1985-12-20
FI91413B (fi) 1994-03-15
EP0153845B1 (en) 1993-04-21
IE940016L (en) 1985-08-23
EP0153845A2 (en) 1985-09-04
JPS61502396A (ja) 1986-10-23
JPH0742318B2 (ja) 1995-05-10
IE63601B1 (en) 1995-05-17
FI91413C (fi) 1994-06-27
WO1985003705A1 (en) 1985-08-29
EP0518391A1 (en) 1992-12-16
KR850700246A (ko) 1985-12-26
DE3587276T2 (de) 1993-07-29
KR870000812B1 (ko) 1987-04-20
EP0153845A3 (en) 1988-09-07
DK486685D0 (da) 1985-10-23
FI854122A0 (fi) 1985-10-22
DK486685A (da) 1985-10-23
GR850454B (es) 1985-06-19
NO171729B (no) 1993-01-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060213