ES2015413A6 - Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)> - Google Patents

Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)>

Info

Publication number
ES2015413A6
ES2015413A6 ES8902146A ES8902146A ES2015413A6 ES 2015413 A6 ES2015413 A6 ES 2015413A6 ES 8902146 A ES8902146 A ES 8902146A ES 8902146 A ES8902146 A ES 8902146A ES 2015413 A6 ES2015413 A6 ES 2015413A6
Authority
ES
Spain
Prior art keywords
leu
glu
analogs
ala
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8902146A
Other languages
English (en)
Inventor
Jean Edouard F Rivier
Wylie Walker Vale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES2015413A6 publication Critical patent/ES2015413A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Vehicle Body Suspensions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Amplifiers (AREA)
  • Control Of Eletrric Generators (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Details Of Television Scanning (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PEPTIDOS ANALOGOS AL FACTOR LIBERADOR DE CORTICOTROPINA (CRF) DE FORMULA (I): Y-RSI1-RSI2-RSI3-RSI4-RSI5-ILE-SER-RSI8-RSI9-LEU-RSI11-RSI12-RSI13-RSI14-LEU-ARG-RSI17-RSI18-RSI19-RSI20-RSI21-RSI22-RSI23-RSI24-RSI25-RSI26-RSI27-RSI28-RSI29-GLN-ALA-RSI32-RSI33-ASN-ARG-RSI36-RSI37-RSI38-RSI39-RSI40-RSI41-NHSI2 DONDE Y ES ACILO CON 7 O MENOS ATOMOS DE CARBONO O HIDROGENO, Y LOS SIMBOLOS R REPRESENTAN AMINOACIDOS. CNSISTE EN FORMAR UN PEPTIDO PRECURSOR QUE TIENE AL MENOS UN GRUPO PROTECTOR AÑADIENDO SECUENCIALMENTE AMINOACIDOS BLOQUEADOS A UN SOPORTE DE RESINA Y DESPROTEGIENDO CON ACIDO TRIFLUOROACETICO, ENTRE 0GC Y LA TEMPERATURA AMBIENTE, ESCINDIR TODOS LOS GRUPOS PROTECTORES Y EL ENLACE DE ANCLAJE A DICHO SOPORTE POR MEDIO DE FLUORURO DE HIDROGENO, A UNA TEMPERATURA DE -20GC A 0GC, Y, OPCIONALMENTE, CONVERTIR EL PEPTIDO RESULTANTE EN SUS SALES DE ADICION NO TOXICAS. LOS PEPTIDOS OBTENIDOS CON UTILES PARA REDUCIR LA TENSION ARTERIAL Y MODULAR LA SECRECION DE ACTH, CORTICOSTEROIDES Y PRODUCTOS DERIVADOS DEL GEN DE PRO-OPIOMELANOCORTINA.
ES8902146A 1988-06-21 1989-06-20 Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)> Expired - Fee Related ES2015413A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20953788A 1988-06-21 1988-06-21

Publications (1)

Publication Number Publication Date
ES2015413A6 true ES2015413A6 (es) 1990-08-16

Family

ID=22779145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8902146A Expired - Fee Related ES2015413A6 (es) 1988-06-21 1989-06-20 Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)>

Country Status (15)

Country Link
EP (1) EP0403591B1 (es)
JP (1) JP2745157B2 (es)
KR (1) KR0139799B1 (es)
AT (1) ATE111486T1 (es)
AU (1) AU617831B2 (es)
CA (1) CA1341406C (es)
DE (1) DE68918271T2 (es)
DK (1) DK175402B1 (es)
ES (1) ES2015413A6 (es)
FI (1) FI94421C (es)
GR (1) GR1000705B (es)
IE (1) IE64788B1 (es)
NO (1) NO178151C (es)
WO (1) WO1989012646A1 (es)
ZA (1) ZA894317B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62607B1 (en) * 1990-03-23 1995-02-22 Salk Inst For Biological Studi CRF analogs
US5235036A (en) * 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
AU704838B2 (en) * 1994-09-12 1999-05-06 Trustees Of The University Of Pennsylvania, The Corticotropin release inhibiting factor and methods of using same
US6039956A (en) * 1994-09-12 2000-03-21 Pennsylvania, Trustees Of The University Of, The Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
US6214797B1 (en) 1995-06-13 2001-04-10 The Salk Institute For Biological Studies Urocortin peptides, nucleic acid encoding same methods for using same
EP0845035A2 (en) * 1995-06-13 1998-06-03 The Salk Institute For Biological Studies Urocortin peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US4594329A (en) * 1984-05-14 1986-06-10 The Salk Institute For Biological Studies CRF analogs
EP0153845B1 (en) * 1984-02-23 1993-04-21 The Salk Institute For Biological Studies Crf analogs

Also Published As

Publication number Publication date
ZA894317B (en) 1990-02-28
NO900775L (no) 1990-04-23
KR900701839A (ko) 1990-12-04
NO178151B (no) 1995-10-23
FI94421B (fi) 1995-05-31
IE892000L (en) 1989-12-21
EP0403591B1 (en) 1994-09-14
DK175402B1 (da) 2004-09-27
CA1341406C (en) 2002-12-03
IE64788B1 (en) 1995-09-06
DK45990A (da) 1990-02-21
KR0139799B1 (ko) 1998-07-01
ATE111486T1 (de) 1994-09-15
DE68918271T2 (de) 1995-02-02
GR1000705B (el) 1992-10-08
EP0403591A4 (en) 1991-11-21
FI900726A0 (fi) 1990-02-14
DK45990D0 (da) 1990-02-21
AU617831B2 (en) 1991-12-05
AU3770689A (en) 1990-01-12
WO1989012646A1 (en) 1989-12-28
NO900775D0 (no) 1990-02-19
GR890100405A (en) 1990-05-11
JP2745157B2 (ja) 1998-04-28
NO178151C (no) 1996-01-31
JPH03501616A (ja) 1991-04-11
DE68918271D1 (de) 1994-10-20
EP0403591A1 (en) 1990-12-27
FI94421C (fi) 1995-09-11

Similar Documents

Publication Publication Date Title
AU565699B2 (en) Crf analogs
ES2015413A6 (es) Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)>
EP0361954A3 (en) Crf analogs
DE3587276D1 (de) Crf-analoga.
ATE169639T1 (de) Crf-analoge
ZA898329B (en) Fish crf

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100315