GR1000705B - Αναλογα crf - Google Patents

Αναλογα crf

Info

Publication number
GR1000705B
GR1000705B GR890100405A GR890100405A GR1000705B GR 1000705 B GR1000705 B GR 1000705B GR 890100405 A GR890100405 A GR 890100405A GR 890100405 A GR890100405 A GR 890100405A GR 1000705 B GR1000705 B GR 1000705B
Authority
GR
Greece
Prior art keywords
leu
glu
ala
analogs
gln
Prior art date
Application number
GR890100405A
Other languages
English (en)
Other versions
GR890100405A (en
Inventor
Jean Eduard Frederic Rivier
Wylie Walker Vale Jr
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of GR890100405A publication Critical patent/GR890100405A/el
Publication of GR1000705B publication Critical patent/GR1000705B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Vehicle Body Suspensions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Amplifiers (AREA)
  • Control Of Eletrric Generators (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Details Of Television Scanning (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Κοινολογούνται ανάλογα CRF που μπορούν να χορηγηθούν για την επίτευξη μιας ουσιαστικής ανύψωσης των ACTH, β-ενδορφίνης, β- λιποτροπίνης, άλλων προϊόντων του γονιδίου προ- απιομελανοκορτίνης και κορτικοστερόνης επιπέδων και/ή ελάττωση της πίεσης του αίματος σε μια εκτεταμένη χρονική περίοδο. Ενα ανάλογο που βρέθηκε να είναι ιδιαίτερα ισχυρό είναι το: H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-His-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Αla-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2. Στα ανάλογα ένα ή περισσότερα από τα πρώτα πέντε υπολείμματα του Ν-άκρου μπορούν να παραλειφθούν ή να υποκατασταθούν με ένα πεπτίδιο των ως 10 αμινοξέων μήκος και/ή παράγοντα ακυλίωσης που περιέχει ως 7 άτομα άνθρακος. Μπορούν επίσης να γίνουν ένας αριθμός άλλων υποκαταστάσεων σε όλη την αλυσίδα. Τα ανάλογα αυτά ή φαρμακευτικά ή κτηνιατρικά αποδεκτά αλάτια τους, σε διασπορά σε ένα φαρμακευτικά ή κτηνιατρικά αποδεκτό υγρό ή στερεό φορέα, μπορούν να χορηγηθούν σε θηλαστικά περιλαμβάνοντας ανθρώπους. Τα ανάλογα αυτά μπορούν επίσης να χρησιμοποιηθούν ως διεγερτικά για την επαναφορά της διάθεσης και βελτίωσης της μνήμης και της μάθησης. ω
GR890100405A 1988-06-21 1989-06-16 Αναλογα crf GR1000705B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20953788A 1988-06-21 1988-06-21

Publications (2)

Publication Number Publication Date
GR890100405A GR890100405A (en) 1990-05-11
GR1000705B true GR1000705B (el) 1992-10-08

Family

ID=22779145

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100405A GR1000705B (el) 1988-06-21 1989-06-16 Αναλογα crf

Country Status (15)

Country Link
EP (1) EP0403591B1 (el)
JP (1) JP2745157B2 (el)
KR (1) KR0139799B1 (el)
AT (1) ATE111486T1 (el)
AU (1) AU617831B2 (el)
CA (1) CA1341406C (el)
DE (1) DE68918271T2 (el)
DK (1) DK175402B1 (el)
ES (1) ES2015413A6 (el)
FI (1) FI94421C (el)
GR (1) GR1000705B (el)
IE (1) IE64788B1 (el)
NO (1) NO178151C (el)
WO (1) WO1989012646A1 (el)
ZA (1) ZA894317B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2121778T3 (es) * 1990-03-23 1998-12-16 Salk Inst For Biological Studi Analogos de crf.
US5235036A (en) * 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
US6039956A (en) * 1994-09-12 2000-03-21 Pennsylvania, Trustees Of The University Of, The Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
CA2199734A1 (en) * 1994-09-12 1996-03-21 Fraser Aird Corticotropin release inhibiting factor and methods of using same
CA2223792A1 (en) * 1995-06-13 1997-01-03 The Salk Institute For Biological Studies Urocortin peptides
US6214797B1 (en) 1995-06-13 2001-04-10 The Salk Institute For Biological Studies Urocortin peptides, nucleic acid encoding same methods for using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594329A (en) * 1984-05-14 1986-06-10 The Salk Institute For Biological Studies CRF analogs
EP0518391A1 (en) * 1984-02-23 1992-12-16 The Salk Institute For Biological Studies CRF analogs
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists

Also Published As

Publication number Publication date
CA1341406C (en) 2002-12-03
AU617831B2 (en) 1991-12-05
NO178151C (no) 1996-01-31
AU3770689A (en) 1990-01-12
ES2015413A6 (es) 1990-08-16
FI900726A0 (fi) 1990-02-14
EP0403591B1 (en) 1994-09-14
DK45990D0 (da) 1990-02-21
DE68918271T2 (de) 1995-02-02
ATE111486T1 (de) 1994-09-15
GR890100405A (en) 1990-05-11
FI94421B (fi) 1995-05-31
FI94421C (fi) 1995-09-11
NO900775L (no) 1990-04-23
DK45990A (da) 1990-02-21
IE64788B1 (en) 1995-09-06
KR900701839A (ko) 1990-12-04
NO178151B (no) 1995-10-23
NO900775D0 (no) 1990-02-19
EP0403591A4 (en) 1991-11-21
EP0403591A1 (en) 1990-12-27
ZA894317B (en) 1990-02-28
DE68918271D1 (de) 1994-10-20
WO1989012646A1 (en) 1989-12-28
DK175402B1 (da) 2004-09-27
KR0139799B1 (ko) 1998-07-01
JP2745157B2 (ja) 1998-04-28
IE892000L (en) 1989-12-21
JPH03501616A (ja) 1991-04-11

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