KR930007386B1 - γ-사이클로덱스트린 유도체의 제조방법 - Google Patents

γ-사이클로덱스트린 유도체의 제조방법 Download PDF

Info

Publication number
KR930007386B1
KR930007386B1 KR1019860000831A KR860000831A KR930007386B1 KR 930007386 B1 KR930007386 B1 KR 930007386B1 KR 1019860000831 A KR1019860000831 A KR 1019860000831A KR 860000831 A KR860000831 A KR 860000831A KR 930007386 B1 KR930007386 B1 KR 930007386B1
Authority
KR
South Korea
Prior art keywords
alkyl
active ingredient
cyclodextrin
derivative
composition
Prior art date
Application number
KR1019860000831A
Other languages
English (en)
Korean (ko)
Other versions
KR860009032A (ko
Inventor
빌리 베르너 뮐러 베른트
Original Assignee
쟈안센 파아마슈우티카 엔. 부이.
폴 아드리안 쟈안센
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쟈안센 파아마슈우티카 엔. 부이., 폴 아드리안 쟈안센 filed Critical 쟈안센 파아마슈우티카 엔. 부이.
Publication of KR860009032A publication Critical patent/KR860009032A/ko
Application granted granted Critical
Publication of KR930007386B1 publication Critical patent/KR930007386B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019860000831A 1985-03-15 1986-02-06 γ-사이클로덱스트린 유도체의 제조방법 KR930007386B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8506792 1985-03-15
GB858506792A GB8506792D0 (en) 1985-03-15 1985-03-15 Derivatives of y-cyclodextrin

Publications (2)

Publication Number Publication Date
KR860009032A KR860009032A (ko) 1986-12-19
KR930007386B1 true KR930007386B1 (ko) 1993-08-09

Family

ID=10576063

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860000831A KR930007386B1 (ko) 1985-03-15 1986-02-06 γ-사이클로덱스트린 유도체의 제조방법

Country Status (22)

Country Link
US (1) US4764604A (US07446107-20081104-C00009.png)
EP (2) EP0197571B1 (US07446107-20081104-C00009.png)
JP (1) JP2562809B2 (US07446107-20081104-C00009.png)
KR (1) KR930007386B1 (US07446107-20081104-C00009.png)
AT (2) ATE124055T1 (US07446107-20081104-C00009.png)
AU (1) AU583599B2 (US07446107-20081104-C00009.png)
CA (1) CA1300130C (US07446107-20081104-C00009.png)
CY (1) CY1918A (US07446107-20081104-C00009.png)
DE (2) DE3650336T2 (US07446107-20081104-C00009.png)
DK (1) DK176156B1 (US07446107-20081104-C00009.png)
ES (1) ES8705899A1 (US07446107-20081104-C00009.png)
FI (1) FI84076C (US07446107-20081104-C00009.png)
GB (1) GB8506792D0 (US07446107-20081104-C00009.png)
GR (1) GR860685B (US07446107-20081104-C00009.png)
HK (1) HK131896A (US07446107-20081104-C00009.png)
HU (2) HU198092B (US07446107-20081104-C00009.png)
IE (1) IE66673B1 (US07446107-20081104-C00009.png)
NO (1) NO167578C (US07446107-20081104-C00009.png)
NZ (1) NZ215350A (US07446107-20081104-C00009.png)
PT (1) PT82186B (US07446107-20081104-C00009.png)
SG (1) SG48788A1 (US07446107-20081104-C00009.png)
ZA (1) ZA861930B (US07446107-20081104-C00009.png)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6333341A (ja) * 1986-07-28 1988-02-13 Seitetsu Kagaku Co Ltd 配糖体の処理方法
JPS63117003A (ja) * 1986-10-31 1988-05-21 Agency Of Ind Science & Technol シクロデキストリン誘導体
DE3710569A1 (de) * 1986-10-31 1988-05-19 Agency Ind Science Techn Cyclodextrinverbindung, sie verwendender ultraduenner film und verfahren zur herstellung
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1203968B (it) * 1987-04-24 1989-02-23 Bononi Ricerca Complessi di b-ciclodestrina ad attivita' antimicotica
NZ224497A (en) * 1987-05-18 1990-04-26 Janssen Pharmaceutica Nv Pharmaceutical composition comprising flunarizine
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5637575A (en) * 1988-01-19 1997-06-10 The Trustees Of The University Of Pennsylvania Methods of inhibiting restenosis
IE64346B1 (en) * 1988-01-19 1995-07-26 Moses Judah Folkman Growth inhibiting agent and the use thereof
US5183809A (en) * 1990-02-15 1993-02-02 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
US5236944A (en) * 1988-03-28 1993-08-17 Janssen Pharmaceutica N.V. Compounds, compositions and anti-neoplastic methods
WO1989010739A1 (en) * 1988-05-11 1989-11-16 Board Of Regents, The University Of Texas System Hydroxyalkyl cyclodextrin-antifungal polyene antibiotics complexes
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
AU616571B2 (en) * 1988-10-28 1991-10-31 Shiseido Company Ltd. Cosmetic composition containing inclusion product with hydroxyalkylated cyclodextrin
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
US5096893A (en) * 1989-04-03 1992-03-17 The United States Of America As Represented By The Department Of Health And Human Services Regioselective substitutions in cyclodextrins
ES2116982T3 (es) * 1989-04-03 1998-08-01 Janssen Pharmaceutica Nv Sustituciones regioselectivas en ciclodextrinas.
US5441944A (en) * 1989-04-23 1995-08-15 The Trustees Of The University Of Pennsylvania Substituted cyclodextrin sulfates and their uses as growth modulating agents
FR2647343B1 (fr) * 1989-05-24 1994-05-06 Rhone Poulenc Sante Nouvelle forme pharmaceutique poreuse et sa preparation
IL94514A0 (en) * 1989-06-02 1991-03-10 Ciba Geigy Ag Intravenous solutions with a rapid onset of action
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
US5064944A (en) * 1989-09-12 1991-11-12 Advanced Separation Technologies Inc. Chiral separation media
US5154738A (en) * 1989-09-12 1992-10-13 Advanced Separation Technologies, Inc. Chiral separation media
WO1991004026A1 (en) * 1989-09-14 1991-04-04 Australian Commercial Research & Development Limited Drug delivery compositions
EP0435826A1 (de) * 1989-12-27 1991-07-03 Ciba-Geigy Ag Intravenöse Lösungen für Status Epilepticus
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
HU212730B (en) * 1990-03-28 1996-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
US5241059A (en) * 1990-05-21 1993-08-31 Toppan Printing Co., Ltd. Cyclodextrin derivatives
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
JP2711759B2 (ja) * 1990-10-24 1998-02-10 エスエス製薬 株式会社 止瀉剤組成物
CA2061891A1 (en) * 1991-03-08 1992-09-09 Robert F. Van Ginckel Flunarizine containing anti-neoplastic compositions
US5446030A (en) * 1991-09-19 1995-08-29 Weisz; Paul B. Prevention of hemolysis
US5231089A (en) * 1991-12-02 1993-07-27 University Of Florida Method of improving oral bioavailability of carbamazepine
JPH05262764A (ja) * 1992-01-24 1993-10-12 Morishita Roussel Kk １−アリール−２−（１ｈ−１，２，４−トリアゾー ル−１−イル）エタノール誘導体
US5300280A (en) * 1992-02-14 1994-04-05 Mallinckrodt Medical, Inc. Stabilized radiopharmaceutical kits
PL172358B1 (en) * 1992-03-18 1997-09-30 Janssen Pharmaceutica Nv Stereoisomeric form of itraconazole or saperconazole and method of obtaining same
FR2693728B1 (fr) * 1992-07-17 1994-09-23 Orsan Procédé de fabrication de cyclodextrines partiellement méthylées et composés obtenus.
US5494901A (en) * 1993-01-05 1996-02-27 Javitt; Jonathan C. Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent
US5665767A (en) * 1993-03-05 1997-09-09 Hexal Pharma Gmbh Crystalline cyclodextrin complexes of ranitidine hydrochloride, process for their preparation and pharmaceutical compositions containing the same
US6346518B1 (en) 1993-03-10 2002-02-12 Janssen Pharmaceutica N.V. Itraconazole and saperconazole stereoisomers
BR9405858A (pt) * 1993-03-31 1995-12-12 Univ Pennsylvania Processos de afetar o crescimento de tecido vivo em mamiferos compostos e composiçÕes para os mesmos
PH31594A (en) * 1993-09-30 1998-11-03 Janssen Pharmaceutica Nv Oral formulations on an antifungal.
DE4333598A1 (de) * 1993-10-01 1995-04-06 Consortium Elektrochem Ind Verfahren zur Herstellung von alkylierten Cyclodextrin-Derivaten, nach dem Verfahren herstellbare methylierte Cyclodextrin-Derivate und die Verwendung der Produkte
CZ306394A3 (en) * 1993-12-14 1995-08-16 Lilly Co Eli Aqueous solution of inclusion complex of benzothiophene derivative with water-soluble cyclodextrins, process of its preparation and a pharmaceutical composition containing thereof
DE4414138A1 (de) * 1994-04-22 1995-10-26 Consortium Elektrochem Ind Acylierte gamma-Cyclodextrine
TW438601B (en) * 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
DE4428654A1 (de) * 1994-08-12 1996-02-15 Consortium Elektrochem Ind Wasserlösliche Cyclodextrinderivate mit lipophilen Substituenten und Verfahren zu ihrer Herstellung
US5679573A (en) * 1995-07-27 1997-10-21 Abbott Laboratories Stabilized aqueous steroid immunoassay standards with cyclodextrins
US5681828A (en) * 1995-12-19 1997-10-28 Pitha; Josef Selective alkylations of cyclodextrins leading to derivatives which have a rigidly extended cavity
US5935941A (en) * 1997-10-24 1999-08-10 Pitha; Josef Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity
US5891909A (en) * 1996-03-29 1999-04-06 3-Dimensional Pharmaceuticals, Inc. Amidinohydrazones as protease inhibitors
EP0954326B2 (en) 1996-04-19 2009-07-22 Grifols Inc. A process for viral inactivation of lyophilized blood proteins
EP0838225A3 (en) * 1996-10-25 1999-03-24 Hiji, Yasutake Aqueous local anesthetic solution
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
RU2218153C2 (ru) * 1997-03-26 2003-12-10 Жансен Фармасетика Н.В. Драже, имеющее ядро, покрытое противогрибковым средством и полимером
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
WO1999033467A1 (en) 1997-12-31 1999-07-08 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6344486B1 (en) 1998-04-03 2002-02-05 3-Dimensional Pharmaceuticals, Inc. Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
IL139162A0 (en) 1998-04-24 2001-11-25 Dimensional Pharm Inc Amidinohydrazone, alkoxyguanidine and aminoguanidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US7091192B1 (en) * 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
AR020650A1 (es) * 1998-08-10 2002-05-22 Poly Med Inc Polimeros fosforilados y conjugados de los mismos
US6432448B1 (en) 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
DK1163234T3 (da) 1999-03-24 2006-02-27 Scherer Technologies Inc R P Farmaceutiske formuleringer med forbedret vandoplöselighed
US6326492B1 (en) 1999-05-27 2001-12-04 3-Dimensional Pharmaceuticals, Inc. Heterocyclic protease inhibitors
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
DE19930553A1 (de) * 1999-07-02 2001-01-11 Wacker Chemie Gmbh Verfahren zur Herstellung von alkylierten Cyclodextrin-Derivaten
ATE250056T1 (de) 1999-07-09 2003-10-15 Dimensional Pharm Inc Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel
US8614291B2 (en) * 1999-08-10 2013-12-24 Poly-Med, Inc. Phosphorylated polymers and conjugates thereof
AU7480800A (en) 1999-09-13 2001-04-17 3-Dimensional Pharmaceuticals, Inc. Azacycloalkanone serine protease inhibitors
US6784165B1 (en) * 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
FR2808691B1 (fr) 2000-05-12 2005-06-24 Coletica Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine
WO2001087360A2 (en) * 2000-05-15 2001-11-22 The Procter & Gamble Company Compositions comprising cyclodextrin derivatives
MXPA03000512A (es) * 2000-07-17 2003-10-06 Dimensional Pharm Inc Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas.
CA2417914A1 (en) 2000-08-04 2002-02-14 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
AU2002225763A1 (en) 2000-11-28 2002-06-11 Fmc Corporation Edible pga(propylene glycol alginate) coating composition
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
US7446107B2 (en) * 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
WO2003074474A2 (en) * 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
JP2005538953A (ja) * 2002-05-28 2005-12-22 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド 新規チオフェンアミジン、それらの組成物、および補体媒介疾患および病気を治療する方法
US6828311B2 (en) 2002-05-29 2004-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Formulation for the parenteral application of a sodium channel blocker
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
EP1511490A4 (en) * 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
CN100360117C (zh) * 2002-06-21 2008-01-09 转化医药公司 具有提高的溶出度的药物组合物
EP1534340B1 (en) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20040248850A1 (en) * 2003-02-11 2004-12-09 Kemia, Inc. Compounds for the treatment of HIV infection
EP2272503B1 (en) 2003-03-28 2013-03-20 Ares Trading S.A. Oral formulations of cladribine
SG175450A1 (en) * 2003-03-28 2011-11-28 Ares Trading Sa Oral formulations of cladribine
EA009714B1 (ru) * 2003-03-28 2008-02-28 Арес Трейдинг С.А. Препараты кладрибина для улучшенной пероральной доставки и доставки через слизистые оболочки
WO2004091613A2 (en) 2003-04-10 2004-10-28 3-Dimensional Pharmaceuticals, Inc. Substituted phenyl acetamides and their use as protease inhibitors
AU2004238217A1 (en) * 2003-04-24 2004-11-25 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
US20050059645A1 (en) * 2003-07-31 2005-03-17 Bodor Nicholas S. Methods for the treatment of male and female sexual dysfunction
US7504401B2 (en) * 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
DE10344967B4 (de) * 2003-09-07 2011-07-28 Henkel AG & Co. KGaA, 40589 Alkoxylgruppen-haltige Cyclodextrin-Derivate; Verfahren zu deren Herstellung und deren Verwendung
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
NZ545744A (en) 2003-09-22 2009-12-24 Baxter Int High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products
CN1294912C (zh) * 2004-03-01 2007-01-17 上海医药工业研究院 伊曲康唑盐酸盐组合物及其冻干粉针
WO2007112274A2 (en) 2006-03-28 2007-10-04 Javelin Pharmaceuticals, Inc. Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin
WO2007109459A2 (en) * 2006-03-21 2007-09-27 Janssen Pharmaceutica, Nv Pyridines and pyridine n-oxides as modulators of thrombin
KR20150050595A (ko) 2006-03-28 2015-05-08 자블린 파머슈티칼스 인코포레이티드 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형
US20080280891A1 (en) * 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
US20090247624A1 (en) 2006-07-28 2009-10-01 Onconova Therapeutics Inc. Formulations of radioprotective alpha beta unsaturated aryl sulfones
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
EP2529793B1 (en) 2007-06-08 2016-08-10 Georgia State University Research Foundation, Inc. Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria
JP5048398B2 (ja) * 2007-06-13 2012-10-17 大蔵製薬株式会社 抗真菌剤の医薬組成物
US8845627B2 (en) 2008-08-22 2014-09-30 Boston Scientific Scimed, Inc. Regulating pressure to lower temperature in a cryotherapy balloon catheter
EP2194429A1 (en) * 2008-12-02 2010-06-09 Eastman Kodak Company Gumming compositions with nano-particles for improving scratch sensitivity in image and non-image areas of lithographic printing plates
BR112012012210B8 (pt) * 2009-11-23 2021-05-25 Cerulean Pharma Inc conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano
US20140221490A1 (en) 2011-07-20 2014-08-07 Hospira, Inc. Methods of treating pain
CN102499909B (zh) * 2011-12-27 2013-08-07 哈尔滨三联药业有限公司 伊曲康唑分散片及其制备方法
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) * 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US4371673A (en) * 1980-07-21 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble forms of retinoids
JPS57106698A (en) * 1980-12-22 1982-07-02 Kyowa Hakko Kogyo Co Ltd Easily absorbable map composition and preparation containing the same
JPS58173102A (ja) * 1982-04-06 1983-10-12 Teijin Ltd エ−テル化サイクロデキストリンの単離精製法
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives

Also Published As

Publication number Publication date
NO167578B (no) 1991-08-12
DE3650655T2 (de) 1998-03-12
GB8506792D0 (en) 1985-04-17
ES8705899A1 (es) 1987-05-16
FI84076C (fi) 1991-10-10
AU5476086A (en) 1986-10-16
JPS61275301A (ja) 1986-12-05
DK121486A (da) 1986-09-16
EP0636634A1 (en) 1995-02-01
EP0197571A3 (en) 1987-09-30
CA1300130C (en) 1992-05-05
ATE124055T1 (de) 1995-07-15
FI861064A0 (fi) 1986-03-14
SG48788A1 (en) 1998-05-18
ATE159954T1 (de) 1997-11-15
ZA861930B (en) 1987-10-28
DE3650655D1 (de) 1997-12-11
PT82186B (pt) 1988-04-21
NO167578C (no) 1991-11-20
AU583599B2 (en) 1989-05-04
NO860971L (no) 1986-09-16
DK176156B1 (da) 2006-10-23
IE860685L (en) 1986-09-15
CY1918A (en) 1997-03-07
JP2562809B2 (ja) 1996-12-11
GR860685B (en) 1986-07-11
US4764604A (en) 1988-08-16
DE3650336D1 (de) 1995-07-27
US4764604B1 (US07446107-20081104-C00009.png) 1990-06-12
FI861064A (fi) 1986-09-16
IE66673B1 (en) 1996-01-24
EP0636634B1 (en) 1997-11-05
KR860009032A (ko) 1986-12-19
FI84076B (fi) 1991-06-28
PT82186A (en) 1986-04-01
NZ215350A (en) 1989-03-29
DE3650336T2 (de) 1995-11-02
EP0197571B1 (en) 1995-06-21
ES552984A0 (es) 1987-05-16
HK131896A (en) 1996-07-26
EP0197571A2 (en) 1986-10-15
HU206381B (en) 1992-10-28
DK121486D0 (da) 1986-03-14
HUT42514A (en) 1987-07-28
HU198092B (en) 1989-07-28

Similar Documents

Publication Publication Date Title
KR930007386B1 (ko) γ-사이클로덱스트린 유도체의 제조방법
US4870060A (en) Derivatives of γ-cylodextrin
FI86140B (fi) Foerfarande foer framstaellning av en farmaceutisk beredning som innehaoller ett i vatten svaorloesligt eller i vatten instabilt laekemedel.
US6407079B1 (en) Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US4727064A (en) Pharmaceutical preparations containing cyclodextrin derivatives
EP2467379B1 (en) Process for the production of coevaporates and complexes comprising voriconazole and cyclodextrin
HU176215B (en) Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
CN104364268B (zh) 包含纤维素醚的熔融挤出的组合物
PL195280B1 (pl) Kompleks inhibitora RAS-farnezylotransferazy o ulepszonej rozpuszczalności w wodzie i trwałości oraz kompozycja inhibitora RAS-farnezylotransferazy
EP0639380B1 (en) Cyclodextrin inclusion product of taxol, process for producing the same, and its use
EP1272531B1 (en) Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds
CN108137714A (zh) 新颖的甲基化环糊精以及其生产方法
FI86507B (fi) Foerfarande foer framstaellning av terapeutiska kompositioner innehaollande y-cyklodextrinderivat.
KR20070069567A (ko) 저장안정성이 우수한 ｓ-오메프라졸 함유 포접 복합체 및이의 제조방법
IE950700L (en) Novel derivatives of þ-cyclodextrin
KR920008700B1 (ko) 수-난용성 또는 수-불안정성 약제와 β-사이클로덱스트린 에테르의 수용성 복합체의 제조방법
KR20050105565A (ko) 저장안정성이 우수한 벤즈이미다졸 유도체 함유 포접복합체 및 이의 제조방법
NO171888B (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat inneholdende medisinske stoffer som er lite opploeselige eller ustabile i vann
CA2189863C (en) Mucoadhesive emulsions containing cyclodextrin
DK200201960A (da) Nye derivater af y-cyclodextrin, fremgangsmåder til deres fremstilling samt præparater indeholdende disse og fremgangsmåder til deres fremstilling

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20050722

Year of fee payment: 13

EXPY Expiration of term