ES8705899A1 - Un procedimiento para la preparacion de un eter o eter de alfa-ciclodextrina. - Google Patents

Un procedimiento para la preparacion de un eter o eter de alfa-ciclodextrina.

Info

Publication number
ES8705899A1
ES8705899A1 ES552984A ES552984A ES8705899A1 ES 8705899 A1 ES8705899 A1 ES 8705899A1 ES 552984 A ES552984 A ES 552984A ES 552984 A ES552984 A ES 552984A ES 8705899 A1 ES8705899 A1 ES 8705899A1
Authority
ES
Spain
Prior art keywords
gamma
cyclodextrin
alkyl
novel derivatives
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552984A
Other languages
English (en)
Other versions
ES552984A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES8705899A1 publication Critical patent/ES8705899A1/es
Publication of ES552984A0 publication Critical patent/ES552984A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN ETER O ETER-MIXTO DE G-CICLODEXTRINA. CONSISTE EN HACER REACCIONAR A UNA G-CICLODEXTRINA CON EL AGENTE 0-ALQUILANTE, EN PRESENCIA DE UNA BASE COMO HIDRURO DE SODIO Y DE CALCIO, EN METANOL O AGUA, ENTRE 30 Y 200JC Y DURANTE 15 MINUTOS Y 24 HORAS. LAS G-CICLODEXTRINAS ESTAN SUSTITUIDAS CON ETILO, HIDROXIBUTILO, HIDROXIALQUILO DE C 2 A 4 Y CON GRADO DE SUSTITUCION ENTRE 0,125 A 3. EL AGENTE 0-ALQUILANTE SE ELIGE ENTRE CLORURO DE METILO, CLOROACETATO DE ETILO Y METILOXIRANO.SE UTILIZAN COMO AGENTES COMPLEJANTES Y SOLUBILIZANTES Y COMO ANTIRREUMATICOS NO ESTEROIDES.
ES552984A 1985-03-15 1986-03-13 Un procedimiento para la preparacion de un eter o eter de alfa-ciclodextrina. Expired ES8705899A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858506792A GB8506792D0 (en) 1985-03-15 1985-03-15 Derivatives of y-cyclodextrin

Publications (2)

Publication Number Publication Date
ES8705899A1 true ES8705899A1 (es) 1987-05-16
ES552984A0 ES552984A0 (es) 1987-05-16

Family

ID=10576063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES552984A Expired ES8705899A1 (es) 1985-03-15 1986-03-13 Un procedimiento para la preparacion de un eter o eter de alfa-ciclodextrina.

Country Status (22)

Country Link
US (1) US4764604A (es)
EP (2) EP0636634B1 (es)
JP (1) JP2562809B2 (es)
KR (1) KR930007386B1 (es)
AT (2) ATE159954T1 (es)
AU (1) AU583599B2 (es)
CA (1) CA1300130C (es)
CY (1) CY1918A (es)
DE (2) DE3650655T2 (es)
DK (1) DK176156B1 (es)
ES (1) ES8705899A1 (es)
FI (1) FI84076C (es)
GB (1) GB8506792D0 (es)
GR (1) GR860685B (es)
HK (1) HK131896A (es)
HU (2) HU198092B (es)
IE (1) IE66673B1 (es)
NO (1) NO167578C (es)
NZ (1) NZ215350A (es)
PT (1) PT82186B (es)
SG (1) SG48788A1 (es)
ZA (1) ZA861930B (es)

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PT82186B (pt) 1988-04-21
EP0197571A2 (en) 1986-10-15
JPS61275301A (ja) 1986-12-05
AU583599B2 (en) 1989-05-04
HU206381B (en) 1992-10-28
DE3650336T2 (de) 1995-11-02
DK176156B1 (da) 2006-10-23
HK131896A (en) 1996-07-26
DK121486A (da) 1986-09-16
EP0636634B1 (en) 1997-11-05
ZA861930B (en) 1987-10-28
FI861064A0 (fi) 1986-03-14
HU198092B (en) 1989-07-28
HUT42514A (en) 1987-07-28
IE860685L (en) 1986-09-15
DE3650655D1 (de) 1997-12-11
NZ215350A (en) 1989-03-29
IE66673B1 (en) 1996-01-24
EP0636634A1 (en) 1995-02-01
CA1300130C (en) 1992-05-05
KR860009032A (ko) 1986-12-19
US4764604A (en) 1988-08-16
NO167578B (no) 1991-08-12
KR930007386B1 (ko) 1993-08-09
GR860685B (en) 1986-07-11
DE3650655T2 (de) 1998-03-12
AU5476086A (en) 1986-10-16
CY1918A (en) 1997-03-07
FI861064A (fi) 1986-09-16
EP0197571A3 (en) 1987-09-30
ATE159954T1 (de) 1997-11-15
SG48788A1 (en) 1998-05-18
GB8506792D0 (en) 1985-04-17
FI84076B (fi) 1991-06-28
FI84076C (fi) 1991-10-10
NO860971L (no) 1986-09-16
US4764604B1 (es) 1990-06-12
PT82186A (en) 1986-04-01
DK121486D0 (da) 1986-03-14
ES552984A0 (es) 1987-05-16
EP0197571B1 (en) 1995-06-21
NO167578C (no) 1991-11-20
DE3650336D1 (de) 1995-07-27
ATE124055T1 (de) 1995-07-15
JP2562809B2 (ja) 1996-12-11

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