KR930006011A - 벤즈아닐리드 유도체 - Google Patents
벤즈아닐리드 유도체 Download PDFInfo
- Publication number
- KR930006011A KR930006011A KR1019920016904A KR920016904A KR930006011A KR 930006011 A KR930006011 A KR 930006011A KR 1019920016904 A KR1019920016904 A KR 1019920016904A KR 920016904 A KR920016904 A KR 920016904A KR 930006011 A KR930006011 A KR 930006011A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- group
- phenyl
- alkyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- ZVSKZLHKADLHSD-UHFFFAOYSA-N benzanilide Chemical class C=1C=CC=CC=1C(=O)NC1=CC=CC=C1 ZVSKZLHKADLHSD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 125000000217 alkyl group Chemical group 0.000 claims abstract 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 18
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 16
- 125000005843 halogen group Chemical group 0.000 claims abstract 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 15
- 125000001424 substituent group Chemical group 0.000 claims abstract 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 13
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 12
- 239000012453 solvate Substances 0.000 claims abstract 12
- 238000011282 treatment Methods 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000004429 atom Chemical group 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 4
- 125000004423 acyloxy group Chemical group 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 3
- 125000002252 acyl group Chemical group 0.000 claims abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims abstract 2
- 208000015114 central nervous system disease Diseases 0.000 claims abstract 2
- 206010034010 Parkinsonism Diseases 0.000 claims 6
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 6
- -1 4-methyl-1-piperazinyl Chemical group 0.000 claims 5
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- LUQVCHRDAGWYMG-UHFFFAOYSA-N 4-phenylbenzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CC=CC=C1 LUQVCHRDAGWYMG-UHFFFAOYSA-N 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000027534 Emotional disease Diseases 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003176 neuroleptic agent Substances 0.000 claims 2
- 230000000701 neuroleptic effect Effects 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- JHWZKGFHGIRICG-UHFFFAOYSA-N 2-(3-chloro-4-phenylphenyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-5-methyl-2H-1,3,4-oxadiazole Chemical compound ClC1=C(C=CC(=C1)C1OC(=NN1C1=CC(=C(C=C1)OC)N1CCN(CC1)C)C)C1=CC=CC=C1 JHWZKGFHGIRICG-UHFFFAOYSA-N 0.000 claims 1
- BNMLGQSJDCUPQT-UHFFFAOYSA-N 2-[4-bromo-3-(4-methylpiperazin-1-yl)phenyl]-5-methyl-3-(3-methyl-4-phenylphenyl)-3H-1,2,4-oxadiazole Chemical compound BrC1=C(C=C(C=C1)N1OC(=NC1C1=CC(=C(C=C1)C1=CC=CC=C1)C)C)N1CCN(CC1)C BNMLGQSJDCUPQT-UHFFFAOYSA-N 0.000 claims 1
- AWUKTKWMDBNDTR-UHFFFAOYSA-N 2-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-5-(3-methyl-4-phenylphenyl)-3H-1,2,4-oxadiazole Chemical compound COC1=C(C=C(C=C1)N1OC(=NC1C)C1=CC(=C(C=C1)C1=CC=CC=C1)C)N1CCN(CC1)C AWUKTKWMDBNDTR-UHFFFAOYSA-N 0.000 claims 1
- ZBJAFBUPURNUOZ-UHFFFAOYSA-N 2-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-(3-methyl-4-phenylphenyl)-3H-thiadiazole Chemical compound COC1=C(C=C(C=C1)N1SC=C(N1)C1=CC(=C(C=C1)C1=CC=CC=C1)C)N1CCN(CC1)C ZBJAFBUPURNUOZ-UHFFFAOYSA-N 0.000 claims 1
- KCZMFHBWPZJTRT-UHFFFAOYSA-N 2-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-5-methyl-3-(3-methyl-4-phenylphenyl)-3H-1,2,4-oxadiazole Chemical compound COC1=C(C=C(C=C1)N1OC(=NC1C1=CC(=C(C=C1)C1=CC=CC=C1)C)C)N1CCN(CC1)C KCZMFHBWPZJTRT-UHFFFAOYSA-N 0.000 claims 1
- HTXDUSSGKPIHBK-UHFFFAOYSA-N 2-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-5-methyl-3-(4-phenylphenyl)-3H-1,2,4-oxadiazole Chemical compound COC1=C(C=C(C=C1)N1OC(=NC1C1=CC=C(C=C1)C1=CC=CC=C1)C)N1CCN(CC1)C HTXDUSSGKPIHBK-UHFFFAOYSA-N 0.000 claims 1
- WUAWTTGQJUXWLK-UHFFFAOYSA-N 5-methyl-3-[4-methyl-3-(4-methylpiperazin-1-yl)phenyl]-2-(3-methyl-4-phenylphenyl)-2H-1,3,4-oxadiazole Chemical compound CC1=C(C=CC(=C1)C1OC(=NN1C1=CC(=C(C=C1)C)N1CCN(CC1)C)C)C1=CC=CC=C1 WUAWTTGQJUXWLK-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- KBASPNJVJPBAAU-UHFFFAOYSA-N ClC1=C(C=C(C=C1)N1OC(=NC1C1=CC(=C(C=C1)C1=CC=CC=C1)C)C)N1CCN(CC1)C Chemical compound ClC1=C(C=C(C=C1)N1OC(=NC1C1=CC(=C(C=C1)C1=CC=CC=C1)C)C)N1CCN(CC1)C KBASPNJVJPBAAU-UHFFFAOYSA-N 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000017701 Endocrine disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- YDBCEBYHYKAFRX-UHFFFAOYSA-N GR 127935 Chemical compound C1=C(N2CCN(C)CC2)C(OC)=CC=C1NC(=O)C(C=C1)=CC=C1C(C(=C1)C)=CC=C1C1=NOC(C)=N1 YDBCEBYHYKAFRX-UHFFFAOYSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019430 Motor disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 208000037386 Typhoid Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000027744 congestion Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 125000005059 halophenyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- QXLNAYIFEMXTDZ-UHFFFAOYSA-N n-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide Chemical compound C1=C(N2CCN(C)CC2)C(OC)=CC=C1NC(=O)C(C=C1)=CC=C1C(C(=C1)C)=CC=C1C1=NN=C(C)O1 QXLNAYIFEMXTDZ-UHFFFAOYSA-N 0.000 claims 1
- KPNDZYJBDZIKBN-UHFFFAOYSA-N n-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide Chemical compound C1=C(N2CCN(C)CC2)C(OC)=CC=C1NC(=O)C(C=C1)=CC=C1C(C(=CC=1)C)=CC=1C1=NN=C(C)O1 KPNDZYJBDZIKBN-UHFFFAOYSA-N 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 201000008297 typhoid fever Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/107—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with two aryl or substituted aryl radicals attached in positions 2 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919119931A GB9119931D0 (en) | 1991-09-18 | 1991-09-18 | Chemical compounds |
| GB9119931.5 | 1991-09-18 | ||
| GB929205338A GB9205338D0 (en) | 1992-03-12 | 1992-03-12 | Chemical compounds |
| GB9205338.8 | 1992-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930006011A true KR930006011A (ko) | 1993-04-20 |
Family
ID=26299553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920016904A Ceased KR930006011A (ko) | 1991-09-18 | 1992-09-17 | 벤즈아닐리드 유도체 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5340810A (enExample) |
| EP (1) | EP0533268B1 (enExample) |
| JP (1) | JP3295143B2 (enExample) |
| KR (1) | KR930006011A (enExample) |
| CN (1) | CN1071919A (enExample) |
| AP (1) | AP303A (enExample) |
| AT (1) | ATE204262T1 (enExample) |
| AU (1) | AU656021B2 (enExample) |
| CA (1) | CA2078505A1 (enExample) |
| CZ (1) | CZ285492A3 (enExample) |
| DE (1) | DE69232003T2 (enExample) |
| DK (1) | DK0533268T3 (enExample) |
| ES (1) | ES2162792T3 (enExample) |
| FI (1) | FI924160A7 (enExample) |
| HU (1) | HUT65608A (enExample) |
| IL (1) | IL103198A (enExample) |
| IS (1) | IS1618B (enExample) |
| MX (1) | MX9205280A (enExample) |
| MY (1) | MY130233A (enExample) |
| NO (1) | NO923618L (enExample) |
| NZ (1) | NZ244373A (enExample) |
| OA (1) | OA10049A (enExample) |
| PL (1) | PL295960A1 (enExample) |
| PT (1) | PT533268E (enExample) |
| RU (1) | RU2077535C1 (enExample) |
| TW (1) | TW224097B (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW240217B (enExample) * | 1992-12-30 | 1995-02-11 | Glaxo Group Ltd | |
| EP0712397B1 (en) * | 1993-08-06 | 1999-04-21 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
| US5905080A (en) * | 1993-08-20 | 1999-05-18 | Smithkline Beecham, P.L.C. | Amide and urea derivatives as 5HT1D receptor antagonists |
| US5696122A (en) * | 1993-09-03 | 1997-12-09 | Smithkline Beecham P.L.C. | Indole and indoline derivatives as 5HT1D receptor antagonists |
| EP0716656A1 (en) * | 1993-09-03 | 1996-06-19 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
| JPH09503773A (ja) * | 1993-10-19 | 1997-04-15 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ−１ｄレセプター拮抗剤用のベンズアニリド誘導体 |
| JPH09506101A (ja) * | 1993-12-07 | 1997-06-17 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄ拮抗薬として有用な複素環式ビフェニリルアミド類 |
| US20020086053A1 (en) * | 1993-12-15 | 2002-07-04 | Smithkline Beecham Plc | Formulations, tablets of paroxetine and process to prepare them |
| US5889022A (en) * | 1993-12-21 | 1999-03-30 | Smithkline Beecham, P.L.C. | Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity |
| GB9326008D0 (en) * | 1993-12-21 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
| JPH09512804A (ja) * | 1994-05-06 | 1997-12-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ１ｄアンタゴニストとして有用なビフェニルカルボキシアミド類 |
| AU2565595A (en) * | 1994-05-28 | 1995-12-21 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
| FR2722788B1 (fr) * | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| US5597826A (en) | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
| US5527920A (en) * | 1994-11-18 | 1996-06-18 | Singh; Inder P. | Economical manufacturing process for 1,2,3-triazoles |
| EP0799226B1 (en) | 1994-12-22 | 2001-02-07 | Smithkline Beecham Plc | Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| US6166034A (en) * | 1995-11-08 | 2000-12-26 | Smithkline Beecham P. L. C | Spiro piperidine derivatives as 5HT1D receptor antagonists |
| US5670526A (en) * | 1995-12-21 | 1997-09-23 | Otsuka Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoles |
| FR2744450A1 (fr) * | 1996-02-02 | 1997-08-08 | Pf Medicament | Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| FR2744449B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| GB9605883D0 (en) * | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| GB9605945D0 (en) * | 1996-03-21 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| SK131498A3 (en) | 1996-03-29 | 2000-09-12 | Pfizer | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USEì (54) AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| JP3890453B2 (ja) * | 1996-09-18 | 2007-03-07 | リードケミカル株式会社 | 新規２，４−ジオキソピロリジンおよび２，４−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬 |
| FR2761064B1 (fr) * | 1997-03-20 | 1999-06-04 | Pf Medicament | Piperazines derivees d'amines cycliques, leur preparation et leur application comme medicaments |
| HUP0001123A3 (en) * | 1997-04-18 | 2002-04-29 | Smithkline Beecham Plc | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
| SE9900190D0 (sv) | 1999-01-22 | 1999-01-22 | Astra Ab | New compounds |
| SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| WO1999007700A1 (en) * | 1997-08-09 | 1999-02-18 | Smithkline Beecham Plc | Bicyclic compounds as ligands for 5-ht1 receptors |
| SE9703376D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | A new combination |
| SE9703375D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | A new combination |
| SE9703374D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | A new combination |
| HUP0102622A3 (en) * | 1998-07-20 | 2002-12-28 | Merck Patent Gmbh | Biphenyl derivatives, process for producing them and pharmaceutical compositions containing them |
| GB9826412D0 (en) * | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
| KR20020030126A (ko) | 1999-09-25 | 2002-04-22 | 피터 기딩스 | ５―ｈｔ１ｂ 길항제로서의 피페라진 유도체 |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US6514482B1 (en) * | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6864262B2 (en) * | 2000-11-29 | 2005-03-08 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof |
| AU2002327627B2 (en) | 2001-09-14 | 2006-09-14 | Methylgene Inc. | Inhibitors of histone deacetylase |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124932D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| EP1474395B1 (en) | 2002-02-12 | 2007-10-17 | Smithkline Beecham Corporation | Nicotinamide derivates useful as p38 inhibitors |
| EP2630954B1 (en) * | 2002-03-20 | 2016-10-05 | Civitas Therapeutics, Inc. | Pulmonary delivery for levodopa |
| US6930137B2 (en) * | 2002-05-31 | 2005-08-16 | Fina Technology, Inc. | Method of improving blown film processing performance and physical properties |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| SE0203778D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | A new oral immediated release dosage form |
| CA2515780C (en) | 2003-02-20 | 2012-12-11 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| AU2003304416A1 (en) * | 2003-08-13 | 2005-03-07 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
| EP1689721B1 (en) * | 2003-11-26 | 2010-07-14 | Pfizer Products Inc. | Aminopyrazole derivatives as gsk-3 inhibitors |
| US20050215551A1 (en) * | 2004-03-25 | 2005-09-29 | Solvay Pharmaceuticals B.V. | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders |
| AR049478A1 (es) | 2004-03-25 | 2006-08-09 | Solvay Pharm Bv | Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas. |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| MXPA06013941A (es) | 2004-06-08 | 2007-12-10 | Neurosearch Sweden Ab | Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina. |
| AU2005293754B2 (en) | 2004-10-13 | 2011-07-21 | Teva Pharmaceuticals International Gmbh | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine |
| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| WO2007077457A2 (en) * | 2006-01-06 | 2007-07-12 | The Royal Veterinary College | Treatment of equine laminitis with 5-ht1b/ 1d antagonists |
| EP1921072A1 (en) * | 2006-11-10 | 2008-05-14 | Laboratorios del Dr. Esteve S.A. | 1,2,3-Triazole derivatives as cannabinoid-receptor modulators |
| CA2842410A1 (en) | 2010-07-23 | 2012-01-26 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for the automated synthesis of small molecules |
| CN103429235A (zh) * | 2010-12-15 | 2013-12-04 | 赖鸿政 | 用于治疗癌症的化合物及其应用 |
| RU2538964C1 (ru) | 2010-12-17 | 2015-01-10 | Мицубиси Танабе Фарма Корпорейшн | Соединение с последовательной арициклической структурой, обладающее активностью ингибирования ацилкофермента а: диацилглицеринацилтрансферазы (dgat1) |
| TWI579272B (zh) | 2011-12-08 | 2017-04-21 | 梯瓦製藥國際有限責任公司 | 普多比啶（ｐｒｉｄｏｐｉｄｉｎｅ）之氫溴酸鹽 |
| EA027748B1 (ru) | 2012-04-04 | 2017-08-31 | Тева Фармасьютикалз Интернэшнл Гмбх | Применение придопидина в комбинации с тетрабеназином для лечения двигательных нарушений и ожирения |
| ES2690315T3 (es) | 2012-06-15 | 2018-11-20 | Mitsubishi Tanabe Pharma Corporation | Compuestos de imidazol y triazol como inhibidores de DGAT-1 |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| WO2023205475A1 (en) * | 2022-04-21 | 2023-10-26 | Nimbus Clotho, Inc. | Ctps1 inhibitors and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3192213A (en) * | 1962-10-12 | 1965-06-29 | Olin Mathieson | Aminoalkyl anilides |
| DE1668723A1 (de) * | 1966-09-16 | 1971-04-08 | Toyo Jozo Kk | Verfahren zum Herstellen von Verbindungen mit Saeureamid-Bindung |
| US4058523A (en) * | 1974-10-14 | 1977-11-15 | Chugai Seiyaku Kabushiki Kaisha | Bis(benzamido)-benzene derivatives |
| AU499714B2 (en) * | 1974-10-14 | 1979-05-03 | Chugai Seiyaku Kabushiki Kaisha | Bis(benzamido)-benzene derivatives & process for preparing thesame |
| US4013647A (en) * | 1976-03-23 | 1977-03-22 | American Home Products Corporation | Morpholine containing tetrazole-5-carboxamide derivatives |
| DE3005287A1 (de) * | 1980-02-13 | 1981-08-20 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinderivate von 1,3,4-oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
| DE3100575A1 (de) * | 1981-01-10 | 1982-09-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel" |
| US4735959A (en) * | 1981-01-10 | 1988-04-05 | Dr. Karl Thomae Gmbh | Carboxylic acid amides and pharmaceutical compositions containing them |
| US4562201A (en) * | 1982-07-26 | 1985-12-31 | American Hospital Supply Corporation | Aminomethyl benzanilides |
| US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
| US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3600288A1 (de) * | 1986-01-08 | 1987-07-16 | Bayer Ag | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonylharnstoff-derivaten |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US4853398A (en) * | 1987-04-13 | 1989-08-01 | Eli Lilly And Company | Leukotriene antagonists and use thereas |
| US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
| EP0324521A3 (en) * | 1988-01-11 | 1991-11-27 | Duphar International Research B.V | Method of treating haematologic diseases and pharmaceutical compositions to be used therefor |
| DE3810848A1 (de) * | 1988-03-30 | 1989-10-19 | Boehringer Ingelheim Kg | Neue 2,3,4-substituierte imidazole und 3,4,5-substituierte 1,2,4-triazole, ihre herstellung und verwendung |
| DE68903263T2 (de) * | 1988-10-10 | 1993-05-19 | Akzo Nv | Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung. |
-
1992
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