DE68903263T2 - Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung. - Google Patents

Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung.

Info

Publication number
DE68903263T2
DE68903263T2 DE8989202429T DE68903263T DE68903263T2 DE 68903263 T2 DE68903263 T2 DE 68903263T2 DE 8989202429 T DE8989202429 T DE 8989202429T DE 68903263 T DE68903263 T DE 68903263T DE 68903263 T2 DE68903263 T2 DE 68903263T2
Authority
DE
Germany
Prior art keywords
nervous system
central nervous
aromatic compounds
substituted aromatic
system effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989202429T
Other languages
English (en)
Other versions
DE68903263D1 (de
Inventor
Johannes Hubertus Wieringa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of DE68903263D1 publication Critical patent/DE68903263D1/de
Application granted granted Critical
Publication of DE68903263T2 publication Critical patent/DE68903263T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
DE8989202429T 1988-10-10 1989-09-28 Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung. Expired - Fee Related DE68903263T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8802470 1988-10-10

Publications (2)

Publication Number Publication Date
DE68903263D1 DE68903263D1 (de) 1992-11-26
DE68903263T2 true DE68903263T2 (de) 1993-05-19

Family

ID=19853017

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989202429T Expired - Fee Related DE68903263T2 (de) 1988-10-10 1989-09-28 Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung.

Country Status (16)

Country Link
US (1) US5051424A (de)
EP (1) EP0365064B1 (de)
JP (1) JPH02134374A (de)
KR (1) KR900006308A (de)
AT (1) ATE81651T1 (de)
AU (1) AU621408B2 (de)
CA (1) CA2000060A1 (de)
DE (1) DE68903263T2 (de)
DK (1) DK498889A (de)
ES (1) ES2052890T3 (de)
FI (1) FI894783A (de)
GR (1) GR3006821T3 (de)
IE (1) IE893129L (de)
NZ (1) NZ230934A (de)
PT (1) PT91932B (de)
ZA (1) ZA897551B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5495046A (en) * 1991-01-04 1996-02-27 Taisho Pharmaceutical Co., Ltd. Alkoxyphenylalkylamine derivatives
EP0598123A4 (de) * 1991-07-19 1995-02-15 Zeria Pharm Co Ltd Piperazinderivate und diese enthaltende arzneimittel.
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
ATE204262T1 (de) * 1991-09-18 2001-09-15 Glaxo Group Ltd Benzanilidderivate als 5-ht1d-antagonisten
GB9119920D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
US5486526A (en) * 1992-04-01 1996-01-23 The University Of Toledo Histamine H3 -receptor antagonists and therapeutic uses thereof
EP0566189A1 (de) * 1992-04-13 1993-10-20 Akzo N.V. Psychotroop-Piperazinderivat
AU674955B2 (en) * 1993-06-25 1997-01-16 Pola Chemical Industries Inc. Dopamine reincorporation inhibitor
US9512105B2 (en) 2011-12-09 2016-12-06 Research Triangle Institute 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE564238A (de) *
DE1137733B (de) * 1954-06-05 1962-10-11 Chem Fab Promonta G M B H Verfahren zur Herstellung von Aryl- und Thienylmethylphenylalkylaminen
US2927924A (en) * 1958-04-03 1960-03-08 Lilly Co Eli Novel phenethyl-substituted piperazines
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
GB8713061D0 (en) * 1987-06-04 1987-07-08 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
AU621408B2 (en) 1992-03-12
EP0365064B1 (de) 1992-10-21
ATE81651T1 (de) 1992-11-15
GR3006821T3 (de) 1993-06-30
IE893129L (en) 1990-04-10
ES2052890T3 (es) 1994-07-16
EP0365064A1 (de) 1990-04-25
CA2000060A1 (en) 1990-04-10
DE68903263D1 (de) 1992-11-26
AU4271389A (en) 1990-04-12
US5051424A (en) 1991-09-24
DK498889D0 (da) 1989-10-09
ZA897551B (en) 1990-07-25
PT91932A (pt) 1990-04-30
PT91932B (pt) 1995-05-31
KR900006308A (ko) 1990-05-07
FI894783A0 (fi) 1989-10-09
JPH02134374A (ja) 1990-05-23
NZ230934A (en) 1990-10-26
FI894783A (fi) 1990-04-11
DK498889A (da) 1990-04-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL