KR920002131B1 - 타아졸리딘디온 유도체의 제조방법 - Google Patents

타아졸리딘디온 유도체의 제조방법 Download PDF

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Publication number
KR920002131B1
KR920002131B1 KR1019850007158A KR850007158A KR920002131B1 KR 920002131 B1 KR920002131 B1 KR 920002131B1 KR 1019850007158 A KR1019850007158 A KR 1019850007158A KR 850007158 A KR850007158 A KR 850007158A KR 920002131 B1 KR920002131 B1 KR 920002131B1
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KR
South Korea
Prior art keywords
compound
methyl
formula
reaction
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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KR1019850007158A
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English (en)
Korean (ko)
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KR860003243A (ko
Inventor
간지 메구로
다께시 후시다
Original Assignee
다께다야꾸힝고오교 가부시끼가이샤
구라바야시 이꾸시로
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Priority claimed from PCT/JP1984/000466 external-priority patent/WO1986002073A1/ja
Priority claimed from PCT/JP1985/000179 external-priority patent/WO1986006069A1/ja
Application filed by 다께다야꾸힝고오교 가부시끼가이샤, 구라바야시 이꾸시로 filed Critical 다께다야꾸힝고오교 가부시끼가이샤
Publication of KR860003243A publication Critical patent/KR860003243A/ko
Application granted granted Critical
Publication of KR920002131B1 publication Critical patent/KR920002131B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
KR1019850007158A 1984-10-03 1985-09-27 타아졸리딘디온 유도체의 제조방법 Expired KR920002131B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
MCPCT/JP/84/00466 1984-10-03
JPPCT/JP84/00466 1984-10-03
PCT/JP1984/000466 WO1986002073A1 (fr) 1984-10-03 1984-10-03 Derives de thiazolidinedione, procede de preparation et composition pharmaceutique les contenant
JP85/00179 1985-04-09
PCT/JP1985/000179 WO1986006069A1 (fr) 1985-04-09 1985-04-09 Derives de thiazolidinedione, leur procede de preparation et composition medicinale les contenant
MCPCT/JP/85/00179 1985-04-09

Publications (2)

Publication Number Publication Date
KR860003243A KR860003243A (ko) 1986-05-21
KR920002131B1 true KR920002131B1 (ko) 1992-03-12

Family

ID=26425066

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007158A Expired KR920002131B1 (ko) 1984-10-03 1985-09-27 타아졸리딘디온 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4725610A (https=)
EP (1) EP0177353B1 (https=)
JP (1) JPS6185372A (https=)
KR (1) KR920002131B1 (https=)
CN (1) CN1003445B (https=)
AT (1) ATE51869T1 (https=)
AU (1) AU583537B2 (https=)
CA (1) CA1263655A (https=)
DE (1) DE3577092D1 (https=)
DK (1) DK444685A (https=)
ES (2) ES8706150A1 (https=)
FI (1) FI81097C (https=)
GR (1) GR852389B (https=)
NO (1) NO157896C (https=)
PT (1) PT81235B (https=)

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AU4817685A (en) 1986-04-10
EP0177353B1 (en) 1990-04-11
FI81097C (fi) 1990-09-10
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CN85107870A (zh) 1986-07-16
DK444685A (da) 1986-04-04
PT81235B (pt) 1987-11-30
DK444685D0 (da) 1985-10-01
ES547507A0 (es) 1987-06-01
ES8706150A1 (es) 1987-06-01
JPS6185372A (ja) 1986-04-30
CN1003445B (zh) 1989-03-01
FI853796L (fi) 1986-04-04
FI81097B (fi) 1990-05-31
AU583537B2 (en) 1989-05-04
NO157896B (no) 1988-02-29
US4725610A (en) 1988-02-16
EP0177353A3 (en) 1986-12-30
DE3577092D1 (de) 1990-05-17
ATE51869T1 (de) 1990-04-15
FI853796A0 (fi) 1985-10-01
CA1263655A (en) 1989-12-05
NO157896C (no) 1988-06-08
ES554559A0 (es) 1987-12-16
GR852389B (https=) 1986-02-04
NO853902L (no) 1986-04-04
ES8801256A1 (es) 1987-12-16
JPH0570626B2 (https=) 1993-10-05
PT81235A (en) 1985-11-01

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