KR910008329B1 - 해중합된 과황산염 헤파린의 제조방법 - Google Patents

해중합된 과황산염 헤파린의 제조방법 Download PDF

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Publication number
KR910008329B1
KR910008329B1 KR1019830006212A KR830006212A KR910008329B1 KR 910008329 B1 KR910008329 B1 KR 910008329B1 KR 1019830006212 A KR1019830006212 A KR 1019830006212A KR 830006212 A KR830006212 A KR 830006212A KR 910008329 B1 KR910008329 B1 KR 910008329B1
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South Korea
Prior art keywords
heparin
depolymerized
persulfate
starting
molecular weight
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Expired
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KR1019830006212A
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English (en)
Korean (ko)
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KR840006812A (ko
Inventor
나지 안나마리아
또리 지안지아코모
Original Assignee
아니크 에스. 피. 에이
카를로 치오니
소시에떼 아노님 사노피
미쉘드 아스
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9280592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR910008329(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 아니크 에스. 피. 에이, 카를로 치오니, 소시에떼 아노님 사노피, 미쉘드 아스 filed Critical 아니크 에스. 피. 에이
Publication of KR840006812A publication Critical patent/KR840006812A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
KR1019830006212A 1982-12-28 1983-12-27 해중합된 과황산염 헤파린의 제조방법 Expired KR910008329B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8221934A FR2538404B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-12-28 1982-12-28
FR8221934 1982-12-28
FR21934/82 1982-12-28

Publications (2)

Publication Number Publication Date
KR840006812A KR840006812A (ko) 1984-12-03
KR910008329B1 true KR910008329B1 (ko) 1991-10-12

Family

ID=9280592

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Application Number Title Priority Date Filing Date
KR1019830006212A Expired KR910008329B1 (ko) 1982-12-28 1983-12-27 해중합된 과황산염 헤파린의 제조방법

Country Status (14)

Country Link
US (1) US4727063A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0116801B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS59133201A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR910008329B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE26281T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU563289B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1210760A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3370632D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK597983A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2538404B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE56566B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL70512A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ206697A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (2) ZA839652B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555993B1 (fr) * 1983-12-06 1986-11-07 Anic Spa Chitosanes 6-sulfates et procede pour leur preparation
US4948881A (en) * 1982-12-28 1990-08-14 Sanofi Process for the depolymerization and sulfation of polysaccharides
IT1163772B (it) * 1983-07-13 1987-04-08 Baldacci Lab Spa Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US5262403A (en) * 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
AR243204A1 (es) * 1986-11-21 1993-07-30 Ajorca Sa Un metodo para la depolimerizacion quimica de polisacaridos.
ATE129254T1 (de) * 1987-03-19 1995-11-15 Arthropharm Pty Ltd Antientzündungsmittel und zusammensetzungen.
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
WO1989008456A1 (en) * 1988-03-15 1989-09-21 The Jewish Hospital Of St. Louis Inhibition of intestinal cholesterol and fatty acid absorption
US4945086A (en) * 1988-05-03 1990-07-31 The Board Of Trustees Of The Leland Stanford Junior University Smooth muscle cell growth inhibitor
JPH04500377A (ja) * 1988-06-03 1992-01-23 イタルファルマコ エッセ ピ ア グリコサミノグリカン塩、その製造方法およびそれを含有する医薬組成物
US5063210A (en) * 1989-04-20 1991-11-05 Lange Iii Louis G Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
US5484777A (en) * 1989-04-20 1996-01-16 Lange, Iii; Louis G. Pancreatic cholesterol esterase inhibitor
US5017565A (en) * 1989-04-20 1991-05-21 Lange Iii Louis G Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
US5340932A (en) * 1989-08-18 1994-08-23 Ajorca S.A. Substances with heparin-like structure and their method of production
ES2062307T3 (es) * 1989-10-04 1994-12-16 Akzo Nv Un proceso para la fabricacion de glicosaminoglicuronano sulfatado con actividad antitrombotica.
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1244373B (it) * 1991-01-18 1994-07-08 Sclavo Spa Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
JPH08506322A (ja) * 1992-11-10 1996-07-09 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド サイトカイン活性の調節のための組成物
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
AU2560995A (en) * 1994-06-06 1996-01-04 Per Bjorn Ostergaard A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase
AU682792B2 (en) 1994-10-13 1997-10-16 Cv Therapeutics, Inc. Method of manufacturing non-absorbable synthetic sulfated polysaccharides
US5922690A (en) * 1996-04-25 1999-07-13 Van Gorp; Cornelius L. Dermatan disulfate, an inhibitor of thrombin generation and activation
EP1039883A4 (en) 1996-07-09 2001-09-26 Keith A Crutcher METHOD FOR TREATING APOLIPOPROTEIN E CONDITIONAL DISEASES
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US6388060B1 (en) 1998-11-06 2002-05-14 Vascular Therapeutics Inc. Process for the sulfation of uronic acid-containing polysaccharides
DE29900874U1 (de) * 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
EP1192187A1 (en) * 1999-06-30 2002-04-03 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
FR2807918B1 (fr) 2000-04-21 2003-07-04 Equip Tech Ind Alimentaires Retourneur avec galets mobiles sur surfaces de guidage
CN1473061A (zh) * 2000-09-08 2004-02-04 ���ܶ�����ҽԺ�о���չ���޹�˾ 抗血栓形成的组合物
US20050119469A1 (en) * 2001-08-31 2005-06-02 Smith Gregory A. Saccharide sulfation methods
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
US8071569B2 (en) * 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
JP4636818B2 (ja) * 2004-06-07 2011-02-23 マルホ株式会社 多硫酸化コンドロイチン硫酸の製造方法
CA2574491C (en) * 2004-07-19 2011-05-24 Onconova Therapeutics, Inc. Formulations for parenteral administration of (e)-2,6-dialkoxystryryl 4-substituted benzylsulfones
ES2299795T3 (es) * 2004-09-13 2008-06-01 Laboratori Derivati Organici S.P.A. Procedimiento de sulfatacion de la condroitina.
JP5107246B2 (ja) * 2005-07-29 2012-12-26 オンコノバ・セラピューティックス・インコーポレーテッド 放射線防護α,β−不飽和アリールスルホンの製剤
US20090247624A1 (en) * 2006-07-28 2009-10-01 Onconova Therapeutics Inc. Formulations of radioprotective alpha beta unsaturated aryl sulfones
US9351992B2 (en) * 2007-11-02 2016-05-31 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
RU2408379C2 (ru) * 2009-03-04 2011-01-10 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран Антикоагулянтное средство с противовоспалительной и противоопухолевой активностью
CN101597343B (zh) * 2009-05-07 2011-06-15 张丽萍 一种低分子肝素的基团修饰方法
US9387256B2 (en) 2010-04-16 2016-07-12 Momenta Pharmaceuticals, Inc. Tissue targeting
BR112012031906A2 (pt) 2010-06-17 2016-08-23 Momenta Pharmaceuticals Inc métodos e composições para modular o crescimento de cabelo e pelos.
EP2710043B1 (en) * 2011-05-20 2016-05-11 Gnosis S.p.A. Shark-like chondroitin sulphate and process for the preparation thereof
JP2016520613A (ja) 2013-05-28 2016-07-14 モメンタ ファーマシューティカルズ インコーポレイテッド 薬学的組成物
CN103833869B (zh) * 2014-02-26 2016-01-20 上海中医药大学 一种木香硫酸化多糖及其制备方法和用途
JP6741277B2 (ja) * 2015-12-30 2020-08-19 シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドShenzhen Hepalink Pharmaceutical Group Co., Ltd. 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
JPWO2018043667A1 (ja) 2016-08-31 2018-08-30 王子ホールディングス株式会社 酸性キシロオリゴ糖の製造方法及び酸性キシロオリゴ糖
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
MX390883B (es) 2017-05-31 2025-03-21 Oji Holdings Corp Preparacion hidratante topica
AU2018333249B2 (en) 2017-09-12 2023-03-02 Oji Holdings Corporation Pentosan polysulfate and method for producing pentosan polysulfate
ES2946281T3 (es) 2017-12-20 2023-07-14 Oji Holdings Corp Pentosano polisulfato y medicamento que contiene pentosano polisulfato

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE498062A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
US2599172A (en) * 1948-11-29 1952-06-03 Searle & Co Sulfuric acid esters of hyaluronic acid and processes for the production thereof
CH277483A (de) * 1949-10-20 1951-08-31 Hoffmann La Roche Verfahren zur Herstellung eines hochaktiven blutgerinnungshemmenden Mittels.
US2697093A (en) * 1949-12-16 1954-12-14 Phillips Petroleum Co Process for production of alkali metal polysaccharide sulfates
US2755275A (en) * 1952-08-29 1956-07-17 Abbott Lab Process for sulfating chitin
ES343957A1 (es) * 1967-08-09 1968-10-01 Rocador Sa Procedimiento de obtencion de polisacaridos sulfatados an- tilipemicos activos por via oral.
JPS5027884A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1973-07-12 1975-03-22
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
SE7811306L (sv) * 1978-11-01 1980-05-02 Rothman Gunnvor Antikoagulationsmedel samt sett for dess framstellning
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4281168A (en) * 1979-04-02 1981-07-28 The Upjohn Company 11-Deoxy-inter-oxa-19-oxo-PGE1 compounds
JPS56803A (en) * 1979-06-18 1981-01-07 Mitsubishi Chem Ind Ltd Preparation of vegetable polysaccharide sulfate ester
US4266077A (en) * 1979-12-26 1981-05-05 American Cyanamid Company Naphthalenetetrayltetrakis(sulfonylimino)-aryl multicarboxylic acids and salts thereof
JPS56120704A (en) * 1980-01-28 1981-09-22 Hepar Ind Inc Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
CA1218986A (en) 1982-12-28 1987-03-10 Annamaria Naggi Process for the depolymerisation and sulfatation of polysaccharides

Also Published As

Publication number Publication date
DK597983A (da) 1984-06-29
EP0116801B1 (fr) 1987-04-01
DE3370632D1 (en) 1987-05-07
US4727063A (en) 1988-02-23
ZA839652B (en) 1984-08-29
FR2538404A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-06-29
KR840006812A (ko) 1984-12-03
IL70512A0 (en) 1984-03-30
ATE26281T1 (de) 1987-04-15
AU2285583A (en) 1984-07-05
DK597983D0 (da) 1983-12-23
JPS59133202A (ja) 1984-07-31
IL70512A (en) 1989-08-15
EP0116801A1 (fr) 1984-08-29
CA1210760A (en) 1986-09-02
JPH0629282B2 (ja) 1994-04-20
IE56566B1 (en) 1991-09-11
AU563289B2 (en) 1987-07-02
FR2538404B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-08-23
JPS59133201A (ja) 1984-07-31
ZA839651B (en) 1985-02-27
IE833062L (en) 1984-06-28
NZ206697A (en) 1986-10-08

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