KR910000028B1 - 제약 혼합제의 제조방법 - Google Patents

제약 혼합제의 제조방법 Download PDF

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Publication number
KR910000028B1
KR910000028B1 KR1019830002854A KR830002854A KR910000028B1 KR 910000028 B1 KR910000028 B1 KR 910000028B1 KR 1019830002854 A KR1019830002854 A KR 1019830002854A KR 830002854 A KR830002854 A KR 830002854A KR 910000028 B1 KR910000028 B1 KR 910000028B1
Authority
KR
South Korea
Prior art keywords
release
mixture
microcapsules
active substance
drug
Prior art date
Application number
KR1019830002854A
Other languages
English (en)
Korean (ko)
Other versions
KR840005024A (ko
Inventor
괴란 빌헬름 켈스트란드 안더스
조한 마트슨 크옐
이바르 스조크비스트 롤프
Original Assignee
아스트라 레케메델 아크티볼라그
스티그 아구렐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라 레케메델 아크티볼라그, 스티그 아구렐 filed Critical 아스트라 레케메델 아크티볼라그
Publication of KR840005024A publication Critical patent/KR840005024A/ko
Application granted granted Critical
Publication of KR910000028B1 publication Critical patent/KR910000028B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019830002854A 1982-06-24 1983-06-24 제약 혼합제의 제조방법 KR910000028B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8203953A SE8203953D0 (sv) 1982-06-24 1982-06-24 Pharmaceutical mixture
SE8203953-8 1982-06-24

Publications (2)

Publication Number Publication Date
KR840005024A KR840005024A (ko) 1984-11-03
KR910000028B1 true KR910000028B1 (ko) 1991-01-19

Family

ID=20347191

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002854A KR910000028B1 (ko) 1982-06-24 1983-06-24 제약 혼합제의 제조방법

Country Status (29)

Country Link
EP (1) EP0101418B1 (fr)
JP (1) JPS5916822A (fr)
KR (1) KR910000028B1 (fr)
AR (1) AR231075A1 (fr)
AT (1) ATE59286T1 (fr)
AU (1) AU561954B2 (fr)
BG (1) BG51341A3 (fr)
CA (1) CA1214726A (fr)
CS (1) CS257769B2 (fr)
CY (1) CY1468A (fr)
DD (1) DD209971A5 (fr)
DE (1) DE3382086D1 (fr)
DK (1) DK161365C (fr)
ES (1) ES523536A0 (fr)
FI (1) FI85213C (fr)
GB (1) GB2122490B (fr)
GR (1) GR78604B (fr)
HK (1) HK98786A (fr)
HU (1) HU189300B (fr)
IE (1) IE55204B1 (fr)
IS (1) IS1325B6 (fr)
MY (1) MY8700292A (fr)
NO (1) NO168745C (fr)
NZ (1) NZ204639A (fr)
PH (1) PH21911A (fr)
PT (1) PT76919B (fr)
SE (1) SE8203953D0 (fr)
SU (1) SU1722207A3 (fr)
ZA (1) ZA833931B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0729927B2 (ja) * 1983-04-09 1995-04-05 日研化学株式会社 テオフィリン徐放性製剤
SE8405611D0 (sv) * 1984-11-09 1984-11-09 Astra Laekemedel Ab Process for stabilization of bacampicillin hydrochloride
IT1183575B (it) * 1985-05-08 1987-10-22 Eurand Spa Formulazione deodorando ad effetto modulante sulla trfaspirazione
NL8503539A (nl) * 1986-01-02 1987-07-16 Warner Lambert Co Sucrose-vrije preparaten.
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
SE8605515D0 (sv) * 1986-12-22 1986-12-22 Astra Laekemedel Ab A liquid dosage form for oral administration of a pharmaceutically active substance
US4874613A (en) * 1987-03-06 1989-10-17 Baker Cummins Pharmaceuticals, Inc. Taste concealing pharmaceutical dosage unit
US5427935A (en) * 1987-07-24 1995-06-27 The Regents Of The University Of Michigan Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes
SE463542B (sv) * 1987-08-31 1990-12-10 Lejus Medical Ab Granulaer instanticerbar produkt samt foerfarande foer dess framstaellning
JPH03504968A (ja) * 1988-04-19 1991-10-31 サウスウェスト・リサーチ・インスティチュート 塩感受性シェル物質を有するカプセルからの活性成分の制御放出
US5064650A (en) * 1988-04-19 1991-11-12 Southwest Research Institute Controlled-release salt sensitive capsule for oral use and adhesive system
FR2653337B1 (fr) * 1989-10-23 1992-02-07 Dow Corning Sa Element a liberation prolongee et procede pour le fabriquer.
CA2068402C (fr) * 1991-06-14 1998-09-22 Michael R. Hoy Enrobage pour masquer le gout pouvant etre utilise dans des comprimes pharmaceutiques croquables
US5364634A (en) * 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
DE4200821A1 (de) * 1992-01-15 1993-07-22 Bayer Ag Geschmacksmaskierte pharmazeutische mittel
JP3265680B2 (ja) * 1992-03-12 2002-03-11 大正製薬株式会社 経口製剤用組成物
DE4312656C2 (de) * 1993-04-19 1996-01-25 Beiersdorf Ag Kühlend wirkende kosmetische oder dermatologische Zusammensetzungen
DE4423078B4 (de) * 1994-07-01 2005-01-13 Awd.Pharma Gmbh & Co. Kg Verfahren zur Herstellung einer Carbamazepin-Arzneiform mit verzögerter Wirkstofffreisetzung
JP3470198B2 (ja) * 1995-05-02 2003-11-25 大正製薬株式会社 経口投与用組成物
DE19706978A1 (de) * 1997-02-21 1998-08-27 Ulrich Dr Posanski Kombinationspräparat für oral applizierbare Antibiotika
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297088A (fr) * 1961-01-31
US3689654A (en) * 1970-09-14 1972-09-05 Morton Norwich Products Inc Pharmaceutical compositions
ES434971A1 (es) * 1974-02-22 1977-05-16 Wellcome Found Metodo para producir un preparado farmaceutico que comprendeuna solucin de digoxina en una envolvente de capsula solu- ble.
SE8003805L (sv) * 1980-05-21 1981-11-22 Haessle Ab En farmaceutisk beredning med forbettrade utlosningsegenskap
US4321253A (en) * 1980-08-22 1982-03-23 Beatty Morgan L Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration
SE8103843L (sv) * 1981-06-18 1982-12-19 Astra Laekemedel Ab Farmaceutisk mixtur
JPS57209223A (en) * 1981-06-19 1982-12-22 Tanabe Seiyaku Co Ltd Microcapsule for intracranial anti hypotension and its production

Also Published As

Publication number Publication date
ATE59286T1 (de) 1991-01-15
FI832197A0 (fi) 1983-06-16
CY1468A (en) 1989-07-21
ZA833931B (en) 1984-07-25
GR78604B (fr) 1984-09-27
FI85213B (fi) 1991-12-13
AR231075A1 (es) 1984-09-28
DK161365C (da) 1991-12-09
JPS5916822A (ja) 1984-01-28
GB2122490A (en) 1984-01-18
ES8403720A1 (es) 1984-04-01
JPH0559089B2 (fr) 1993-08-30
BG51341A3 (en) 1993-04-15
CA1214726A (fr) 1986-12-02
SE8203953D0 (sv) 1982-06-24
HU189300B (en) 1986-06-30
EP0101418A3 (en) 1984-11-14
AU561954B2 (en) 1987-05-21
AU1594383A (en) 1984-01-05
HK98786A (en) 1986-12-24
EP0101418B1 (fr) 1990-12-27
NZ204639A (en) 1986-01-24
NO832293L (no) 1983-12-27
DK272383A (da) 1983-12-25
NO168745B (no) 1991-12-23
IE55204B1 (en) 1990-07-04
MY8700292A (en) 1987-12-31
PT76919B (en) 1986-04-09
DE3382086D1 (de) 1991-02-07
IE831462L (en) 1983-12-24
FI832197L (fi) 1983-12-25
PH21911A (en) 1988-04-08
SU1722207A3 (ru) 1992-03-23
IS2824A7 (is) 1983-12-25
PT76919A (en) 1983-07-01
NO168745C (no) 1992-04-01
IS1325B6 (is) 1988-08-03
GB2122490B (en) 1986-04-03
FI85213C (fi) 1992-03-25
ES523536A0 (es) 1984-04-01
KR840005024A (ko) 1984-11-03
EP0101418A2 (fr) 1984-02-22
DD209971A5 (de) 1984-05-30
GB8317071D0 (en) 1983-07-27
DK161365B (da) 1991-07-01
CS463683A2 (en) 1987-11-12
CS257769B2 (en) 1988-06-15
DK272383D0 (da) 1983-06-14

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A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20020116

Year of fee payment: 12

LAPS Lapse due to unpaid annual fee