KR890011974A - 산화-민감성 화합물을 함유하는 안정한 혼합물, 이의 제조방법 및 산화-민감성 화합물을 안정화하기 위한 배합물의 용도 - Google Patents

산화-민감성 화합물을 함유하는 안정한 혼합물, 이의 제조방법 및 산화-민감성 화합물을 안정화하기 위한 배합물의 용도 Download PDF

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KR890011974A
KR890011974A KR1019890000932A KR890000932A KR890011974A KR 890011974 A KR890011974 A KR 890011974A KR 1019890000932 A KR1019890000932 A KR 1019890000932A KR 890000932 A KR890000932 A KR 890000932A KR 890011974 A KR890011974 A KR 890011974A
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oxidation
vitamin
mixture according
sensitive compounds
sensitive
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KR1019890000932A
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찌하루 후카마찌
슈마커 호스트
베베르트 볼프강
슈나이더 요아힘
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후가와 히데아끼
니신 바디쉐 가부시끼가이샤
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Publication of KR890011974A publication Critical patent/KR890011974A/ko

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

산화-민감성 화합물을 함유하는 안정한 혼합물, 이의 제조방법 및 산화-민감성 화합물을 안정화하기 위한 배합물의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 산화-민감성 화합물, 트리글리세라이드, 착화제 및 피복제를 함유하는 안정한 혼합물.
  2. 제1항에 있어서, 부가적으로 산화방지제를 함유하는 혼합물.
  3. 제1항 또는 2항에 있어서, 트리글리세라이드가 식물성유인 혼합물.
  4. 제1항 내지 3항중 어느 한 항에 있어서, 착화제가 피트산, 인산, 메타-, 피로- 또는 폴리인산 또는 그의 염인 혼합물.
  5. 제1항 내지 4항중 어느 한 항에 있어서, 피복제가 필름 형성제(특히, 단백질), 당 또는 폴리삭카라이드(특히, 알라비아 고무, 알기네이트 또는 전분 유도체)인 혼합물.
  6. 제1항 내지 5항중 어느 한 항에 있어서, 산화-민감성 화합물이 지용성 비타민(특히, 비타민 A 또는 이의 에스테르, 비타민 A산, 비타민 E 또는 비타민 D), 카로티노이드, 방향 또는 향미제인 혼합물.
  7. 제1항 내지 6항중 어느 한 항에 있어서, 비타민 A 또는 이의 에스테르, 피트산, 식물성유 및 젤라틴을 함유하는 혼합물.
  8. 제1항 내지 7항중 어느 한 항에 있어서, 100 내지 600㎛ 범위의 입자크기를 갖는 과립 또는 분상 형태인 혼합물.
  9. 산화-민감성 화합물, 트리글리세라이드, 착화제 및 피복제로부터 분산액을 제조하고 이 분산액을 고체 물질로 전환시킴을 특징으로 하는, 제1항 내지 8항중 어느 한 항에 청구된 화합물의 제조방법.
  10. 제9항에 있어서, 수성 분산액을 제조하고, 건조시키며 과립화하거나 분화시키는 방법.
  11. 산화-민감성 화합물을 안정화하기 위해 트리글리세라이드, 착화제 및 피복제의 배합물을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890000932A 1988-01-29 1989-01-28 산화-민감성 화합물을 함유하는 안정한 혼합물, 이의 제조방법 및 산화-민감성 화합물을 안정화하기 위한 배합물의 용도 KR890011974A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-17232 1988-01-29
JP1723288 1988-01-29

Publications (1)

Publication Number Publication Date
KR890011974A true KR890011974A (ko) 1989-08-23

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KR1019890000932A KR890011974A (ko) 1988-01-29 1989-01-28 산화-민감성 화합물을 함유하는 안정한 혼합물, 이의 제조방법 및 산화-민감성 화합물을 안정화하기 위한 배합물의 용도

Country Status (10)

Country Link
US (1) US4929774A (ko)
EP (1) EP0326026B1 (ko)
KR (1) KR890011974A (ko)
CN (1) CN1023229C (ko)
CA (1) CA1331136C (ko)
DE (1) DE58901641D1 (ko)
DK (1) DK174663B1 (ko)
IL (1) IL88961A (ko)
IN (1) IN171845B (ko)
SU (1) SU1639425A3 (ko)

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EP0326026B1 (de) 1992-06-17
CA1331136C (en) 1994-08-02
DK35589D0 (da) 1989-01-27
US4929774A (en) 1990-05-29
DK35589A (da) 1989-07-30
IL88961A0 (en) 1989-08-15
IN171845B (ko) 1993-01-23
EP0326026A2 (de) 1989-08-02
CN1036220A (zh) 1989-10-11
CN1023229C (zh) 1993-12-22
IL88961A (en) 1992-07-15
EP0326026A3 (en) 1990-11-14
DK174663B1 (da) 2003-08-18
DE58901641D1 (de) 1992-07-23
SU1639425A3 (ru) 1991-03-30

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