KR890009844A - 프로폭시벤젠 유도체 및 이의 제조방법 - Google Patents

프로폭시벤젠 유도체 및 이의 제조방법 Download PDF

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KR890009844A
KR890009844A KR1019880017385A KR880017385A KR890009844A KR 890009844 A KR890009844 A KR 890009844A KR 1019880017385 A KR1019880017385 A KR 1019880017385A KR 880017385 A KR880017385 A KR 880017385A KR 890009844 A KR890009844 A KR 890009844A
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group
derivative
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benzene
propoxybenzene
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KR1019880017385A
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KR950006393B1 (ko
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도시히로 후지와라
두또무 에바따
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스즈끼 다다시
다이이찌 세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

프로폭시벤젠 유도체 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (17)

  1. 하기 일반식의 프로폭시벤젠 유도체.
    상기식에서, Ra는 니트로 그룹, 보호그룹을 가질수 있는 아미노 그룹 또는 -NHCH=C(COO-C1-6알킬)2그룹이고, Rb는 수소원자, 하이드록시 그룹용 보호그룹 또는 치환된 설포닐 그룹이며, Xa및 bb는 동일하거나 상이할 수 있으며, 각각 할로겐 원자이다.
  2. 제1항에 있어서, Ra가 니트로 그룹인 프로폭시 벤젠 유도체.
  3. 제1항에 있어서, Ra가 아미노 그룹인 프로폭시 벤젠 유도체.
  4. 제1항에 있어서, Ra가 -NHCH=C(COO-C1-6알킬)2인 프로폭시벤젠 유도체.
  5. 제1항에 있어서, Rb가 하이드록실 그룹용 보호 그룹들중에서 선택된 그룹인 프로폭시벤젠 유도체.
  6. 제1항에 있어서, Rb가 하이드록실 그룹인 프로폭시벤젠 유도체.
  7. 제1항에 있어서, Rb가 치환된 설포닐 그룹인 프로폭시벤젠 유도체.
  8. 제1항에 있어서, 2,3-디플루오로-6-니트로[(2-(테트라하이드로피란-2-일)옥시프로필]옥시]벤젠인 화합물.
  9. 제1항에 있어서, 6-아미노-2,3-디플로오로-[[2-(테트라하이드로피란-2-일)옥시프로필]옥시]벤젠인 화합물.
  10. 제1항에 있어서, 2,3-디플루오로-6-니트로-[[2-하이드록시프로필)옥시]벤젠인 화합물.
  11. 제1항에 있어서, 6-아미노-2,3-디플루오로-[(2-하이드록시프로필)옥시]벤젠인 화합물.
  12. 제1항에 있어서, 2,3-디플루오로-6-니트로-(2-P-톨루엔-설포닐옥시프로필)옥시벤젠인 화합물.
  13. 제1항에 있어서, 6-아미노-2,3-디풀로오로-(2-P-톨루엔-설포닐옥시프로필)옥시벤젠인 화합물.
  14. 제1항에 있어서, 2,3-디플루오로-6-(2,2-디알콕시카르보닐에테닐)아미노-[2-(하이드록시프로필)옥시]벤젠인 화합물.
  15. 제1항에 있어서, 2,3-디플루오로-6-(2,2-디알콕시카르보닐에테닐)아미노-[2(P-톨루엔설포닐옥시프로필)옥시]벤젠인 화합물.
  16. 일반식(Ⅱ)의 2,3,4-트리할로게노니트로 벤젠유도체와 일반식(Ⅲ)의 1,2-프로판디올 유도체를 염기의 존재하에서 반응시키거나, 일반식(Ⅳ)의 2,3-디할로게노-6-니트로페놀과 일반식(Ⅲ)의 유도체를 미쭈노부(Mitsunobu)시약의 존재하에서 반응시키거나, 일반식(Ⅳ)의 유도체와 일반식(Ⅴ)의 유도체를 염기의 존재하에서 반응시킴을 특징으로 하여, 일반식(Ⅰ)의 프로톡시벤겐 화합물을 제조하는 방법.
    Xd CH2CH(CH3) ORc (Ⅴ)
    상기식에서, Rc는 하이드록실 그룹용 보호그룹이고, Xa, Xb 및 Xc는 동일하거나 상이할 수 있으며 각각 할로겐 원자를 나타내고, Xd는 할로겐 원자 또는 설포닐옥시 그룹이다.
  17. 일반식(XⅤⅢ)의 프로폭시벤젠 유도체를 염기의 존재하에서 폐환시키거나, 일반식(Ⅹ)의 프로폭시벤젠 유도체를 미쭈노부 시약의 존재하에서 폐환시키거나, 일반식(Ⅹ)의 프로폭시벤젠 유도체를 하이드록실 그룹용 할로겐화제에 의해 할라이드로 전화시킨 후, 염기의 존재하에서 폐환시킴을 특징으로 하여, 일반식(ⅩⅤⅡ)의 7,8-디할로게노-3-메틸-2,3-디하이드로-2H-벤즈옥사진 유도체를 제조하는 방법.
    상기식에서, Rd는 치환된 설포닐 그룹이고, Re는 수소원자 또는 -CH=(COO-C1-6알길)2이며, Xa 및 Xb는 제16항에서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880017385A 1987-12-25 1988-12-24 프로폭시벤젠 유도체 및 이의 제조방법 KR950006393B1 (ko)

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Application Number Priority Date Filing Date Title
JP32923087 1987-12-25
JP329230/87 1987-12-25
JP?329230/87 1987-12-25
JP?336489/87 1987-12-28
JP33648987 1987-12-28
JP336489/87 1987-12-28
JP48195/88 1988-03-01
JP?48195/88? 1988-03-01
JP4819588 1988-03-01
JP?75968/88? 1988-03-31
JP7596888 1988-03-31
JP75968/88 1988-03-31

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EP (1) EP0322815B1 (ko)
KR (1) KR950006393B1 (ko)
AT (1) ATE138062T1 (ko)
DE (1) DE3855297T2 (ko)
DK (1) DK175193B1 (ko)
ES (1) ES2090012T3 (ko)
FI (1) FI95567C (ko)
GR (1) GR3020351T3 (ko)
IE (1) IE75342B1 (ko)
NO (1) NO172846C (ko)

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ES2055656B1 (es) * 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
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JP2947503B2 (ja) * 1994-03-02 1999-09-13 エーザイ株式会社 アリルキノン誘導体の製造方法および中間体
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EP2360160B1 (en) * 1999-09-08 2013-07-24 Daiichi Sankyo Company, Limited Intermediates and their use for producing benzoxazine derivative
ES2329554T3 (es) * 2001-03-07 2009-11-27 Daiichi Sankyo Company, Limited Procesos para producir derivados de propoxianilina opticamente activos.
JP2003319530A (ja) * 2002-04-23 2003-11-07 Yazaki Corp 電気接続箱
EP2313357A2 (en) * 2008-06-27 2011-04-27 Futurefuel Chemical Company Systems and methods for the preparation of alkyl aryl ethers
JP6268014B2 (ja) * 2014-03-20 2018-01-24 富士フイルム株式会社 サラシノールの製造に有用な化合物およびそれらの製造法、サラシノールの製造法、ジオール基の保護方法および脱保護方法、並びにジオール基の保護剤

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DK719388D0 (da) 1988-12-23
DE3855297D1 (de) 1996-06-20
FI885942A (fi) 1989-06-26
KR950006393B1 (ko) 1995-06-14
EP0322815A3 (en) 1991-01-02
NO885714L (no) 1989-06-26
NO172846C (no) 1993-09-15
NO885714D0 (no) 1988-12-22
IE75342B1 (en) 1997-08-27
US5136059A (en) 1992-08-04
US5312999A (en) 1994-05-17
DK719388A (da) 1989-06-26
ES2090012T3 (es) 1996-10-16
IE883846L (en) 1989-06-25
ATE138062T1 (de) 1996-06-15
EP0322815B1 (en) 1996-05-15
EP0322815A2 (en) 1989-07-05
DK175193B1 (da) 2004-07-05
NO172846B (no) 1993-06-07
FI95567B (fi) 1995-11-15
DE3855297T2 (de) 1997-01-23
FI95567C (fi) 1996-02-26
GR3020351T3 (en) 1996-09-30

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