KR900012898A - 벤젤설폰아미드 및 이의 제조방법 - Google Patents

벤젤설폰아미드 및 이의 제조방법 Download PDF

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KR900012898A
KR900012898A KR1019900001886A KR900001886A KR900012898A KR 900012898 A KR900012898 A KR 900012898A KR 1019900001886 A KR1019900001886 A KR 1019900001886A KR 900001886 A KR900001886 A KR 900001886A KR 900012898 A KR900012898 A KR 900012898A
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South Korea
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compound
carbon atoms
alkyl
hydrogen
tert
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KR1019900001886A
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KR0175298B1 (ko
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조헨 랑 한스
그란찌 에르놀드
케레크자르토 벨라
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하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K31/00—Housing birds
    • A01K31/18—Chicken coops or houses for baby chicks; Brooders including auxiliary features, e.g. feeding, watering, demanuring, heating, ventilation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Paper (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

벤젤설폰아미드 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)의 벤젠설포아미드.
    상기식에서, R1은 탄소수 1내지 5의 알킬 또는 3내지 5환원(ring member)의 사이클로알킬이고, R2는 탄소수 3내지 5의 측쇄 알킬이며, R3는 수소, 할로겐, 탄소수 1내지 4의 알킬 또는 알콕시이며, R4는 수소, 탄소수 1내지 3의 알킬, 할로겐, 트리플루오로메틸, 라디칼-SOn-A 〔여기에서, A는 탄소수 1내지 3의 알킬이거나, n이 2일 경우에는 NR6R7(여기에서, R6와 R7은 수소 또는 탄소수 1내지 4의 알킬이다)이고, n은 0,1 또는 2이다)〕이고, R5는 수소 또는 탄소수 1내지 3의 알킬이다.
  2. 제1항에 있어서, 치환체중 적어도 하나가 하기 의미를 갖는 화합물(Ⅰ).
    R1은 메틸, 이소프로필 또는 3급-부틸이고, R2는 이소프로필 또는 3급-부틸이며, R3는 수소, 염소 또는 탄소수 1내지 3의 직쇄 또는 측쇄 알콕시이고, R4는 트리플루오로메틸 또는 라디칼-SOn-A(여기에서, A및 n은 상기 언급된 의미를 갖는다)이며, R5는 수소 또는 탄소수 1내지 3의 알킬이다.
  3. 제1항에 있어서, 5-N-(3,5-디-3급-부틸-4-하이드록시페닐설파모일)-2-클로로벤젠-N,N-디메틸설폰아미드, 5-N-(3,5-디-3급 -부틸-4-하이드록시페닐설파모일)-2-클로로벤젠-N,N-메틸설폰아미드, 5-N-(3,5-디-3급-부틸-4-하이드록시페닐설파모일)-2-클로로벤젠설폰아미드, 및 3-N-(3,5-디-3급-부틸-4-하이드록시페닐설파모일)-4-클로로벤젠설폰아미드로 이루어진 그룹중에서 선택되는 화합물(Ⅰ).
  4. 하기 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키고, 필요한 경우 R5가 수소인 일반식(Ⅰ)의 생성화합물을 알킬화시켜 R5가 탄소수 1내지 3의 일반식(Ⅰ) 화합물을 수득함을, 특징으로 하는 화합물(Ⅰ)의 제조방법.
    상기식에서, R1, R2, R3, R4및 R5는 제1항에 정의된 바와 같다.
  5. 제1항에 있어서, 약제로서 사용하기 위한 일반식(Ⅰ)의 화합물.
  6. 약제를 제조하기 위한 제1항에 따른 일반식(Ⅰ)의 화합물의 용도.
  7. 저지혈증제(hypolipidemic)로서의 제1항에 따른 화합물(Ⅰ)의 용도.
  8. 지질-저하 작용 및/또는 산화방지성을 갖는 의약을 제조하기 위한 제1항에 따른 화합물(Ⅰ)의 용도.
  9. 유효량을 제1항에 따른 화합물(Ⅰ) 및 약제학적으로 통상적인 부가물을 함유하는 약제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900001886A 1989-02-18 1990-02-16 벤젠설폰아미드 및 이의 제조방법 KR0175298B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3905075A DE3905075A1 (de) 1989-02-18 1989-02-18 Benzolsulfonamide und verfahren zu ihrer herstellung
DEP3905075.0 1989-02-18

Publications (2)

Publication Number Publication Date
KR900012898A true KR900012898A (ko) 1990-09-03
KR0175298B1 KR0175298B1 (ko) 1999-04-01

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Country Status (17)

Country Link
US (1) US5143937A (ko)
EP (1) EP0384279B1 (ko)
JP (1) JP2851108B2 (ko)
KR (1) KR0175298B1 (ko)
AT (1) ATE104273T1 (ko)
AU (1) AU622765B2 (ko)
CA (1) CA2010272C (ko)
DE (2) DE3905075A1 (ko)
DK (1) DK0384279T3 (ko)
ES (1) ES2052988T3 (ko)
FI (1) FI900760A0 (ko)
IE (1) IE63880B1 (ko)
IL (1) IL93427A (ko)
NO (1) NO172117C (ko)
NZ (1) NZ232550A (ko)
PT (1) PT93160B (ko)
ZA (1) ZA901189B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA92970B (en) * 1991-02-12 1992-10-28 Hoechst Ag Arylsulfonylureas,processes for their preparation,and their use as herbicides and growth regulators
DE4109735A1 (de) * 1991-03-25 1992-10-01 Boehringer Mannheim Gmbh Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US6653331B2 (en) * 1996-07-03 2003-11-25 Pharmacia & Upjohn Company Targeted drug delivery using sulfonamide derivatives
US6284923B1 (en) 1997-08-22 2001-09-04 Tularik Inc Substituted benzene compounds as antiproliferative and cholesterol lowering action
CA2318731C (en) 1998-01-29 2012-05-29 Tularik Inc. Ppar-gamma modulators
US6583157B2 (en) 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
CA2335559A1 (en) 1998-06-25 1999-12-29 Tularik Inc. Arylsulfonanilide phosphates
US6153585A (en) 1998-07-20 2000-11-28 Tularik Inc. Arylsulfonanilide derivatives
KR100642184B1 (ko) 1998-09-23 2006-11-10 암젠 인크 아릴술폰아닐리드 우레아
US7041691B1 (en) * 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
DE19941559A1 (de) * 1999-09-01 2001-03-15 Aventis Pharma Gmbh Verwendung von Bissulfonamiden zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Hyperlipidömie
WO2001082916A2 (en) 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
US20030171399A1 (en) * 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AU2002234165A1 (en) 2000-11-03 2002-05-27 Tularik, Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
WO2005086904A2 (en) * 2004-03-08 2005-09-22 Amgen Inc. Therapeutic modulation of ppar (gamma) activity
CN114129577B (zh) * 2021-12-15 2022-07-12 徐州医科大学 苯磺酰胺化合物在制备预防和/或治疗衰老疾病的药物中的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA618769A (en) * 1961-04-18 Tagmann Eugen Process for the manufacture of sulfamyl-anilines
US2236168A (en) * 1940-02-27 1941-03-25 Du Pont Lubricant
US3165550A (en) * 1960-06-29 1965-01-12 Pfizer & Co C N-substituted p-benzenedisulfonamides
DE1278443C2 (de) * 1963-11-30 1975-07-24 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-disulfonamid-1-chlorbenzolen
US3678039A (en) * 1967-04-27 1972-07-18 Lincoln Harvey Werner 4-trifluoromethyl-anthranilic acids
US3737316A (en) * 1971-08-31 1973-06-05 Eastman Kodak Co Two-equivalent sulfonamido couplers
CA1072359A (en) * 1974-10-08 1980-02-26 Hiroyuki Konishi Method for controlling the growth of plants
US4013621A (en) * 1975-04-29 1977-03-22 Ciba-Geigy Corporation Substituted sulfonamide derivatives of hindered phenols and stabilized compositions
DE3713757A1 (de) * 1987-04-24 1988-11-10 Hoechst Ag Benzolsulfonamidderivate und verfahren zu ihrer herstellung

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DK0384279T3 (da) 1994-08-08
JP2851108B2 (ja) 1999-01-27
JPH02255652A (ja) 1990-10-16
IL93427A (en) 1994-10-21
IL93427A0 (en) 1990-11-29
DE3905075A1 (de) 1990-08-30
US5143937A (en) 1992-09-01
DE59005304D1 (de) 1994-05-19
ES2052988T3 (es) 1994-07-16
FI900760A0 (fi) 1990-02-15
EP0384279A1 (de) 1990-08-29
ATE104273T1 (de) 1994-04-15
NO172117B (no) 1993-03-01
NZ232550A (en) 1992-05-26
ZA901189B (en) 1990-10-31
EP0384279B1 (de) 1994-04-13
CA2010272A1 (en) 1990-08-18
PT93160B (pt) 1995-12-29
NO900750D0 (no) 1990-02-16
NO900750L (no) 1990-08-20
CA2010272C (en) 1999-11-16
AU622765B2 (en) 1992-04-16
PT93160A (pt) 1990-08-31
NO172117C (no) 1993-06-09
AU4985190A (en) 1990-08-23
IE900588L (en) 1990-08-18
KR0175298B1 (ko) 1999-04-01
IE63880B1 (en) 1995-06-14

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