KR890002121A - 신규 벤조피란 유도체, 그의 제조방법 및 이를 함유하는 제약학적 조성물 - Google Patents
신규 벤조피란 유도체, 그의 제조방법 및 이를 함유하는 제약학적 조성물 Download PDFInfo
- Publication number
- KR890002121A KR890002121A KR1019880009213A KR880009213A KR890002121A KR 890002121 A KR890002121 A KR 890002121A KR 1019880009213 A KR1019880009213 A KR 1019880009213A KR 880009213 A KR880009213 A KR 880009213A KR 890002121 A KR890002121 A KR 890002121A
- Authority
- KR
- South Korea
- Prior art keywords
- radical
- amino
- radicals
- benzopyran
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001562 benzopyrans Chemical class 0.000 title claims 14
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title claims 2
- -1 nitro, amino Chemical group 0.000 claims 17
- 239000002253 acid Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 102000001708 Protein Isoforms Human genes 0.000 claims 7
- 108010029485 Protein Isoforms Proteins 0.000 claims 7
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims 7
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- UIZPEXQHMIZQPQ-UHFFFAOYSA-N 1-[2-(3,4-dihydro-2h-chromen-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine Chemical compound C1=C(OC)C(OC)=CC=C1C1CCN(CCC2C3=CC=CC=C3OCC2)CC1 UIZPEXQHMIZQPQ-UHFFFAOYSA-N 0.000 claims 1
- QQONARIVNGENQR-UHFFFAOYSA-N 3-[1-[2-(3,4-dihydro-2h-chromen-4-yl)ethyl]piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound C1COC2=CC=CC=C2C1CCN(CC1)CCC1N1C2=CC=CC=C2NC1=O QQONARIVNGENQR-UHFFFAOYSA-N 0.000 claims 1
- OIXQWWYOFGBKNP-UHFFFAOYSA-N 4-[2-[4-(3,4-dimethoxyphenyl)piperidin-1-yl]ethyl]-3,4-dihydro-2h-chromen-6-amine Chemical compound C1=C(OC)C(OC)=CC=C1C1CCN(CCC2C3=CC(N)=CC=C3OCC2)CC1 OIXQWWYOFGBKNP-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- RMAHMVVHKCNOIL-UHFFFAOYSA-N n-[4-[1-[2-(3,4-dihydro-2h-chromen-4-yl)ethyl]piperidin-4-yl]phenyl]methanesulfonamide Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1CCN(CCC2C3=CC=CC=C3OCC2)CC1 RMAHMVVHKCNOIL-UHFFFAOYSA-N 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000035322 succinylation Effects 0.000 claims 1
- 238000010613 succinylation reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8710453A FR2618437B1 (fr) | 1987-07-23 | 1987-07-23 | Nouveaux derives du benzopyranne, leur preparation et les medicaments qui les contiennent |
| FR8710453 | 1987-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890002121A true KR890002121A (ko) | 1989-04-08 |
Family
ID=9353484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880009213A Withdrawn KR890002121A (ko) | 1987-07-23 | 1988-07-21 | 신규 벤조피란 유도체, 그의 제조방법 및 이를 함유하는 제약학적 조성물 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4977166A (https=) |
| EP (1) | EP0300908B1 (https=) |
| JP (1) | JPS6440476A (https=) |
| KR (1) | KR890002121A (https=) |
| AT (1) | ATE73791T1 (https=) |
| AU (1) | AU606184B2 (https=) |
| DE (1) | DE3869258D1 (https=) |
| DK (1) | DK411388A (https=) |
| FI (1) | FI883486A7 (https=) |
| FR (1) | FR2618437B1 (https=) |
| GR (1) | GR3004090T3 (https=) |
| HU (1) | HUT54145A (https=) |
| NO (1) | NO883279L (https=) |
| NZ (1) | NZ225520A (https=) |
| PT (1) | PT88083B (https=) |
| ZA (1) | ZA885374B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
| AU626881B2 (en) * | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
| FR2658823B1 (fr) * | 1990-02-27 | 1992-04-30 | Adir | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
| DE4319038A1 (de) * | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
| DE4321366A1 (de) * | 1993-06-26 | 1995-01-05 | Merck Patent Gmbh | Piperidine und Piperazine |
| US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
| US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
| CA2176722A1 (en) * | 1993-12-28 | 1995-07-06 | Ruth E. Ten Brink | Heterocyclic compounds for the treatment of cns and cardiovascular disorders |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| FR2717479B1 (fr) * | 1994-03-18 | 1996-06-07 | Pf Medicament | Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique. |
| FR2724656B1 (fr) * | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| JP4754566B2 (ja) | 2005-07-22 | 2011-08-24 | 持田製薬株式会社 | 新規なヘテロシクリデンアセトアミド誘導体 |
| EP2299814A4 (en) * | 2008-05-27 | 2011-06-15 | Reviva Pharmaceuticals Inc | COMPOSITIONS, SYNTHESIS AND METHOD FOR USE OF ANTIPSYCHOTICS ON PIPERAZINE BASIS |
| PT2400968T (pt) | 2009-02-26 | 2016-12-09 | Reviva Pharmaceuticals Inc | Composições, sintese e métodos de utilização dos derivados de arilpiperazína |
| RU2477130C1 (ru) * | 2011-07-12 | 2013-03-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | Средство, обладающее антиаритмическим, антифибрилляторным, противоишемическим действием, и фармацевтическая композиция на его основе |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1583811A (en) * | 1977-05-09 | 1981-02-04 | Laroche Navarron Sa | Chromene derivatives |
| DE3300004A1 (de) * | 1983-01-03 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Substituierte 4-aminomethylenchromane bzw. -chromene, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3411993A1 (de) * | 1984-03-31 | 1985-10-10 | Bayer Ag, 5090 Leverkusen | Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimittel |
| US4803203A (en) * | 1986-11-05 | 1989-02-07 | Warner-Lambert Company | Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
-
1987
- 1987-07-23 FR FR8710453A patent/FR2618437B1/fr not_active Expired
-
1988
- 1988-07-21 JP JP63182768A patent/JPS6440476A/ja active Pending
- 1988-07-21 DE DE8888401890T patent/DE3869258D1/de not_active Expired - Fee Related
- 1988-07-21 KR KR1019880009213A patent/KR890002121A/ko not_active Withdrawn
- 1988-07-21 EP EP88401890A patent/EP0300908B1/fr not_active Expired - Lifetime
- 1988-07-21 AT AT88401890T patent/ATE73791T1/de active
- 1988-07-22 DK DK411388A patent/DK411388A/da not_active Application Discontinuation
- 1988-07-22 PT PT88083A patent/PT88083B/pt not_active IP Right Cessation
- 1988-07-22 FI FI883486A patent/FI883486A7/fi not_active Application Discontinuation
- 1988-07-22 NO NO88883279A patent/NO883279L/no unknown
- 1988-07-22 HU HU883880A patent/HUT54145A/hu unknown
- 1988-07-22 NZ NZ225520A patent/NZ225520A/en unknown
- 1988-07-22 AU AU19713/88A patent/AU606184B2/en not_active Ceased
- 1988-07-22 ZA ZA885374A patent/ZA885374B/xx unknown
-
1989
- 1989-03-22 US US07/327,093 patent/US4977166A/en not_active Expired - Fee Related
-
1992
- 1992-03-19 GR GR910401355T patent/GR3004090T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3004090T3 (https=) | 1993-03-31 |
| EP0300908A1 (fr) | 1989-01-25 |
| DK411388D0 (da) | 1988-07-22 |
| NO883279D0 (no) | 1988-07-22 |
| HUT54145A (en) | 1991-01-28 |
| FI883486A0 (fi) | 1988-07-22 |
| US4977166A (en) | 1990-12-11 |
| AU606184B2 (en) | 1991-01-31 |
| AU1971388A (en) | 1989-01-27 |
| DK411388A (da) | 1989-01-24 |
| ZA885374B (en) | 1989-03-29 |
| NO883279L (no) | 1989-01-24 |
| FR2618437B1 (fr) | 1989-11-17 |
| EP0300908B1 (fr) | 1992-03-18 |
| FR2618437A1 (fr) | 1989-01-27 |
| ATE73791T1 (de) | 1992-04-15 |
| NZ225520A (en) | 1991-03-26 |
| PT88083A (pt) | 1989-06-30 |
| PT88083B (pt) | 1995-03-01 |
| JPS6440476A (en) | 1989-02-10 |
| DE3869258D1 (de) | 1992-04-23 |
| FI883486A7 (fi) | 1989-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19880721 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |