ZA885374B - New benzopyran derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
New benzopyran derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- ZA885374B ZA885374B ZA885374A ZA885374A ZA885374B ZA 885374 B ZA885374 B ZA 885374B ZA 885374 A ZA885374 A ZA 885374A ZA 885374 A ZA885374 A ZA 885374A ZA 885374 B ZA885374 B ZA 885374B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- hydrogen
- benzopyran derivatives
- radical
- preparation
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 nitro, amino Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8710453A FR2618437B1 (fr) | 1987-07-23 | 1987-07-23 | Nouveaux derives du benzopyranne, leur preparation et les medicaments qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA885374B true ZA885374B (en) | 1989-03-29 |
Family
ID=9353484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA885374A ZA885374B (en) | 1987-07-23 | 1988-07-22 | New benzopyran derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4977166A (https=) |
| EP (1) | EP0300908B1 (https=) |
| JP (1) | JPS6440476A (https=) |
| KR (1) | KR890002121A (https=) |
| AT (1) | ATE73791T1 (https=) |
| AU (1) | AU606184B2 (https=) |
| DE (1) | DE3869258D1 (https=) |
| DK (1) | DK411388A (https=) |
| FI (1) | FI883486A7 (https=) |
| FR (1) | FR2618437B1 (https=) |
| GR (1) | GR3004090T3 (https=) |
| HU (1) | HUT54145A (https=) |
| NO (1) | NO883279L (https=) |
| NZ (1) | NZ225520A (https=) |
| PT (1) | PT88083B (https=) |
| ZA (1) | ZA885374B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
| AU626881B2 (en) * | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
| FR2658823B1 (fr) * | 1990-02-27 | 1992-04-30 | Adir | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
| DE4319038A1 (de) * | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
| DE4321366A1 (de) * | 1993-06-26 | 1995-01-05 | Merck Patent Gmbh | Piperidine und Piperazine |
| US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
| US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
| CA2176722A1 (en) * | 1993-12-28 | 1995-07-06 | Ruth E. Ten Brink | Heterocyclic compounds for the treatment of cns and cardiovascular disorders |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| FR2717479B1 (fr) * | 1994-03-18 | 1996-06-07 | Pf Medicament | Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique. |
| FR2724656B1 (fr) * | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| JP4754566B2 (ja) | 2005-07-22 | 2011-08-24 | 持田製薬株式会社 | 新規なヘテロシクリデンアセトアミド誘導体 |
| EP2299814A4 (en) * | 2008-05-27 | 2011-06-15 | Reviva Pharmaceuticals Inc | COMPOSITIONS, SYNTHESIS AND METHOD FOR USE OF ANTIPSYCHOTICS ON PIPERAZINE BASIS |
| PT2400968T (pt) | 2009-02-26 | 2016-12-09 | Reviva Pharmaceuticals Inc | Composições, sintese e métodos de utilização dos derivados de arilpiperazína |
| RU2477130C1 (ru) * | 2011-07-12 | 2013-03-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | Средство, обладающее антиаритмическим, антифибрилляторным, противоишемическим действием, и фармацевтическая композиция на его основе |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1583811A (en) * | 1977-05-09 | 1981-02-04 | Laroche Navarron Sa | Chromene derivatives |
| DE3300004A1 (de) * | 1983-01-03 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Substituierte 4-aminomethylenchromane bzw. -chromene, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3411993A1 (de) * | 1984-03-31 | 1985-10-10 | Bayer Ag, 5090 Leverkusen | Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimittel |
| US4803203A (en) * | 1986-11-05 | 1989-02-07 | Warner-Lambert Company | Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
-
1987
- 1987-07-23 FR FR8710453A patent/FR2618437B1/fr not_active Expired
-
1988
- 1988-07-21 JP JP63182768A patent/JPS6440476A/ja active Pending
- 1988-07-21 DE DE8888401890T patent/DE3869258D1/de not_active Expired - Fee Related
- 1988-07-21 KR KR1019880009213A patent/KR890002121A/ko not_active Withdrawn
- 1988-07-21 EP EP88401890A patent/EP0300908B1/fr not_active Expired - Lifetime
- 1988-07-21 AT AT88401890T patent/ATE73791T1/de active
- 1988-07-22 DK DK411388A patent/DK411388A/da not_active Application Discontinuation
- 1988-07-22 PT PT88083A patent/PT88083B/pt not_active IP Right Cessation
- 1988-07-22 FI FI883486A patent/FI883486A7/fi not_active Application Discontinuation
- 1988-07-22 NO NO88883279A patent/NO883279L/no unknown
- 1988-07-22 HU HU883880A patent/HUT54145A/hu unknown
- 1988-07-22 NZ NZ225520A patent/NZ225520A/en unknown
- 1988-07-22 AU AU19713/88A patent/AU606184B2/en not_active Ceased
- 1988-07-22 ZA ZA885374A patent/ZA885374B/xx unknown
-
1989
- 1989-03-22 US US07/327,093 patent/US4977166A/en not_active Expired - Fee Related
-
1992
- 1992-03-19 GR GR910401355T patent/GR3004090T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3004090T3 (https=) | 1993-03-31 |
| EP0300908A1 (fr) | 1989-01-25 |
| DK411388D0 (da) | 1988-07-22 |
| NO883279D0 (no) | 1988-07-22 |
| KR890002121A (ko) | 1989-04-08 |
| HUT54145A (en) | 1991-01-28 |
| FI883486A0 (fi) | 1988-07-22 |
| US4977166A (en) | 1990-12-11 |
| AU606184B2 (en) | 1991-01-31 |
| AU1971388A (en) | 1989-01-27 |
| DK411388A (da) | 1989-01-24 |
| NO883279L (no) | 1989-01-24 |
| FR2618437B1 (fr) | 1989-11-17 |
| EP0300908B1 (fr) | 1992-03-18 |
| FR2618437A1 (fr) | 1989-01-27 |
| ATE73791T1 (de) | 1992-04-15 |
| NZ225520A (en) | 1991-03-26 |
| PT88083A (pt) | 1989-06-30 |
| PT88083B (pt) | 1995-03-01 |
| JPS6440476A (en) | 1989-02-10 |
| DE3869258D1 (de) | 1992-04-23 |
| FI883486A7 (fi) | 1989-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA885374B (en) | New benzopyran derivatives,their preparation and pharmaceutical compositions containing them | |
| IL69049A0 (en) | Thieno(3,2-c)pyridine derivatives,their preparation and pharmaceutical compositions containing them | |
| ES8702907A1 (es) | Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico | |
| IL104024A (en) | 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them | |
| ES8307760A1 (es) | Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina. | |
| CS557084A2 (en) | Zpusob vyroby 1,4 dihydropyridinu | |
| ES8207180A1 (es) | Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 . | |
| EA200300044A1 (ru) | Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции | |
| DK0549366T3 (da) | Thiazolidinforbindelser indeholdende en quinolingruppe, deres fremstilling og deres terapeutiske anvendelser | |
| IL76175A (en) | N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them | |
| IL85919A (en) | Pharmaceutical compositions for improving sleep comprising n-aryl- piperazinealkanamide derivatives, certain such novel compounds and their preparation | |
| EP0375223A3 (en) | Novel compounds | |
| ES8802222A1 (es) | Un procedimiento para preparar derivados de vinilisoquinolina | |
| IL76535A0 (en) | Furo(3,2-c)pyridine derivatives,their preparation and pharmaceutical compositions containing them | |
| IE900218L (en) | Benzopyran derivatives | |
| IL115085A0 (en) | Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them | |
| YU168491A (sh) | 8-azabiciklo/3,2,1/oktilalkiltiazolidinoli in postopek za njihovo pripravo | |
| JPS55115860A (en) | Novel amidine derivative and its preparation | |
| SE8804436D0 (sv) | Trombolytiska och liknande sammansaettningar | |
| JPS6466153A (en) | Amide compound and digestive tract motion-activator containing said compound as active ingredient | |
| JPS5639086A (en) | Novel piperidine derivative and hypotensive agent containing the same | |
| JPS5212182A (en) | Process for preparation of novel n- substituted indanespiropiperazine derivatives | |
| JPS52128368A (en) | Novel carboxylic acid amide derivatives and their preparation | |
| JPS5219637A (en) | Preparation of novel biscarboxylic acid esters | |
| JPS5312895A (en) | Preparation of novel mitomycin derivatives |