KR890001449B1 - Trans 6-2-(substituted pyrrol-1-yl)alkyl j-pyran 2-one and the process of the preparation thereof - Google Patents
Trans 6-2-(substituted pyrrol-1-yl)alkyl j-pyran 2-one and the process of the preparation thereofInfo
- Publication number
- KR890001449B1 KR890001449B1 KR858501374D KR8501374D KR890001449B1 KR 890001449 B1 KR890001449 B1 KR 890001449B1 KR 858501374 D KR858501374 D KR 858501374D KR 8501374 D KR8501374 D KR 8501374D KR 890001449 B1 KR890001449 B1 KR 890001449B1
- Authority
- KR
- South Korea
- Prior art keywords
- pyran
- trans
- alkyl
- preparation
- substituted pyrrol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65379884A | 1984-09-24 | 1984-09-24 | |
| US06/679,676 US4647576A (en) | 1984-09-24 | 1984-12-10 | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890001449B1 true KR890001449B1 (en) | 1989-05-03 |
Family
ID=27096596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR858501374D Expired KR890001449B1 (en) | 1984-09-24 | 1985-02-04 | Trans 6-2-(substituted pyrrol-1-yl)alkyl j-pyran 2-one and the process of the preparation thereof |
| KR1019850006950A Expired KR890001050B1 (ko) | 1984-09-24 | 1985-09-23 | 트랜스-6-[2-(치환된 피롤-1-일)알킬]-피란-2-온 및 그 제조방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850006950A Expired KR890001050B1 (ko) | 1984-09-24 | 1985-09-23 | 트랜스-6-[2-(치환된 피롤-1-일)알킬]-피란-2-온 및 그 제조방법 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4647576A (https=) |
| EP (1) | EP0179559A3 (https=) |
| KR (2) | KR890001449B1 (https=) |
| AU (1) | AU573027B2 (https=) |
| CA (1) | CA1242721A (https=) |
| DK (1) | DK430485A (https=) |
| ES (1) | ES8701756A1 (https=) |
| FI (1) | FI853632A7 (https=) |
| GR (1) | GR852297B (https=) |
| NO (1) | NO853725L (https=) |
| NZ (1) | NZ213252A (https=) |
| PT (1) | PT81179B (https=) |
Families Citing this family (188)
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| US5001255A (en) * | 1984-12-04 | 1991-03-19 | Sandoz Pharm. Corp. | Idene analogs of mevalonolactone and derivatives thereof |
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| US4973704A (en) * | 1985-10-25 | 1990-11-27 | Sandoz Pharm. Corp. | Pyrrolyl intermediates in the synthesis of pyrrole analogs of mevalonolactone and derivatives thereof |
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US4735958A (en) * | 1986-12-22 | 1988-04-05 | Warner-Lambert Company | Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis |
| US4789682A (en) * | 1987-03-17 | 1988-12-06 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
| US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
| US4775681A (en) * | 1987-06-18 | 1988-10-04 | Warner-Lambert Company | Method of treating fungal infections with trans-6-[2-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones |
| DE3722806A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
| DE3722809A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte |
| DE3817808A1 (de) * | 1987-07-21 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von 2-substituierten pyrrolen |
| US5310938A (en) * | 1987-07-29 | 1994-05-10 | American Cyanamid Company | Substituted arylpyrrole compounds |
| US5010098A (en) * | 1987-07-29 | 1991-04-23 | American Cyanamid Company | Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof |
| CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| US5185328A (en) * | 1987-08-20 | 1993-02-09 | Nissan Chemical Industries Ltd. | Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis |
| US4906624A (en) * | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US4997837A (en) * | 1987-09-08 | 1991-03-05 | Warner-Lambert Company | 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| GB8728314D0 (en) * | 1987-12-03 | 1988-01-06 | May & Baker Ltd | New compositions of matter |
| US4761419A (en) * | 1987-12-07 | 1988-08-02 | Warner-Lambert Company | 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US4868185A (en) * | 1987-12-10 | 1989-09-19 | Warner-Lambert Company | 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| DE3800785A1 (de) * | 1988-01-09 | 1989-07-20 | Hoechst Ag | Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
| NZ227743A (en) * | 1988-01-27 | 1991-01-29 | May & Baker Ltd | Isoquinolinone derivatives and their pharmaceutical compositions |
| US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
| US5097045A (en) * | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5149837A (en) * | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) * | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| US5216174A (en) * | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5245047A (en) * | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| IT1226726B (it) * | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
| US5196440A (en) * | 1988-07-29 | 1993-03-23 | Zambon Group S.P.A. | Compounds active as inhibitors of the cholesterol biosynthesis |
| US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
| DE3832570A1 (de) * | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
| NO893909L (no) * | 1988-10-03 | 1990-04-04 | Glaxo Group Ltd | Fremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater. |
| US4906657A (en) * | 1988-12-21 | 1990-03-06 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| US4957940A (en) * | 1988-12-21 | 1990-09-18 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| JPH03184961A (ja) * | 1989-10-10 | 1991-08-12 | Glaxo Group Ltd | 化合物 |
| IT1237792B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
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| US5103024A (en) * | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
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| KR900001212B1 (ko) * | 1985-10-25 | 1990-02-28 | 산도즈 파마슈티칼스 코오포레이숀 | 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도 |
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1984
- 1984-12-10 US US06/679,676 patent/US4647576A/en not_active Expired - Fee Related
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1985
- 1985-02-04 KR KR858501374D patent/KR890001449B1/ko not_active Expired
- 1985-08-23 CA CA000489315A patent/CA1242721A/en not_active Expired
- 1985-08-27 NZ NZ213252A patent/NZ213252A/en unknown
- 1985-08-29 AU AU46867/85A patent/AU573027B2/en not_active Ceased
- 1985-09-09 EP EP85306382A patent/EP0179559A3/en not_active Withdrawn
- 1985-09-17 ES ES547055A patent/ES8701756A1/es not_active Expired
- 1985-09-20 GR GR852297A patent/GR852297B/el unknown
- 1985-09-20 FI FI853632A patent/FI853632A7/fi not_active Application Discontinuation
- 1985-09-23 NO NO853725A patent/NO853725L/no unknown
- 1985-09-23 KR KR1019850006950A patent/KR890001050B1/ko not_active Expired
- 1985-09-23 DK DK430485A patent/DK430485A/da not_active Application Discontinuation
- 1985-09-24 PT PT81179A patent/PT81179B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO853725L (no) | 1986-03-25 |
| DK430485D0 (da) | 1985-09-23 |
| US4647576A (en) | 1987-03-03 |
| FI853632L (fi) | 1986-03-25 |
| ES547055A0 (es) | 1986-12-01 |
| AU4686785A (en) | 1986-04-10 |
| FI853632A0 (fi) | 1985-09-20 |
| CA1242721A (en) | 1988-10-04 |
| NZ213252A (en) | 1988-03-30 |
| KR860002503A (ko) | 1986-04-26 |
| DK430485A (da) | 1986-03-25 |
| ES8701756A1 (es) | 1986-12-01 |
| PT81179B (en) | 1987-02-13 |
| EP0179559A2 (en) | 1986-04-30 |
| AU573027B2 (en) | 1988-05-26 |
| EP0179559A3 (en) | 1987-07-01 |
| GR852297B (https=) | 1986-01-21 |
| KR890001050B1 (ko) | 1989-04-22 |
| PT81179A (en) | 1985-10-01 |
| FI853632A7 (fi) | 1986-03-25 |
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