KR880701290A - 고정된 효소전극 - Google Patents

고정된 효소전극

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Publication number
KR880701290A
KR880701290A KR1019880700083A KR880700083A KR880701290A KR 880701290 A KR880701290 A KR 880701290A KR 1019880700083 A KR1019880700083 A KR 1019880700083A KR 880700083 A KR880700083 A KR 880700083A KR 880701290 A KR880701290 A KR 880701290A
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KR
South Korea
Prior art keywords
enzyme
enzyme electrode
electrode according
substrate
resin
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KR1019880700083A
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English (en)
Other versions
KR950004906B1 (ko
Inventor
피터 베네토 휴
마이클 델라니 제라드
리챠드 매슨 제레미
프랭크 터스톤 크리스토퍼
레잉 스터링 죤
로버트 드케이저 데이빗
Original Assignee
윌리암 맥크레
캠브릿지 라이프 싸이언스 피엘씨
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Publication of KR880701290A publication Critical patent/KR880701290A/ko
Application granted granted Critical
Publication of KR950004906B1 publication Critical patent/KR950004906B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Inert Electrodes (AREA)
  • Catalysts (AREA)

Abstract

내용 없음.

Description

고정된 효소전극
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 다른 형태의 탄소전극상에 고정된 글루코오스 산화효소와 비교한 본 발명에 따른 글루코오스 산화효소 전극의 감응성을 나타낸다.
제 2도는 글루코오스 산화효소 전극의 안정성을 나타내는 제 1도 그래프이다.

Claims (16)

  1. 효소 각각의 기질의 존재하에서 효소의 촉매적 활성을 전류로서 감응할 수 있고, 수지 결합된 탄소 또는 흑연 입자의 다공성 층으로 조성되거나 이를 함유하는 전기전도성 지지부재의 표면상에 고정되거나 흡착된 효소를 포함하며, 상기 입자들은 상기 다공성 층을 형성하기 위해 결합되기전에 각각의 입자표면상에 균질혼합되거나 침착 또는 흡착되는 미분된 백금 그룹 금속을 가짐으로써, 상기 효소가 흡착 또는 고정되고 상기 층에 거의 균질하게 분산된 상기 백금 그룹 금속과 함께 수지-결합된 탄소 또는 흑연 입자의 거의 비균질한 층을 함유하는 다공성 기질층을 형성하는 효소전극.
  2. 제 1항에 있어서, 상기 백금 그룹금속이 백금 또는 팔라듐인 효소전극.
  3. 제 1항 또는 2항에 있어서, 합성수지 결합체가 플루오로카본 수지 또는 폴리비닐 아세테이트인 효소 전극.
  4. 제 3항에 있어서, 합성 수지 결합제가 폴리테트라플루오로에틸렌인 효소전극.
  5. 제 1항 내지 4항중 어느 한 항에 있어서, 기질 표면상에 고정되거나 흡착된 효소가 산화-환원요소인 효소전극.
  6. 제 5항에 있어서, 산화-환원효소가 글루코오스 산화 효소인 효소전극.
  7. 제 1항 내지 6항중 어느 한 항에 있어서, 전지 전도성 지지부재가 표면층으로서 상기 수지-결합된 탄소가 결합되거나 흑연 입자가 이와 혼합되거나, 또는 상기 미분된 백금 그룹 금속이 이의 표면에 흡착 또는 침착된 전지전도성 기재를 함유하는 효소전극.
  8. 제 7항에 있어서, 전기전도성 지지부재가 전기전도성 탄소 종이인 효소전극.
  9. 제 1항 내지 8항중 어느 한 항에 있어서, 상기 다공성 층이, 상기 백금 그룹 금속이 수지와 결합하기 전에 각각의 입자표면에 침착 또는 흡착된 수지-결합된 탄소 또는 흑연입자를 함유하는 효소전극.
  10. 제 9항에 있어서, 상기 다공성 층이 수지-결합된 백금도금된 탄소분말을 함유하고, 여기에서 상기 분말은 5내지 30nm범위의 입자크기를 갖고 그 표면에 1.5 내지 2.5nm범위의 입자크기를 갖는 교질상 백금이 흡착된 효소전극.
  11. 제 1항 내지 10항중 어느 한항에 있어서, 상기 기질이 투과할 수 있는 미세다공성 막으로 표면이 보호된 효소전극.
  12. 제 11항에 있어서, 상기 막이 폴리카보네이트 막인 효소전극.
  13. 제 1항 내지 12항중 어느 한항에 청구된 효소전극을 도입한 센서(Sensor).
  14. 효소와 촉매적으로 반응하여 측정가능한 전류를 생성시킬 수 있는 효소기질이거나 또는 이런 효소기질로 전환 가능한 분석물을 시료중에서 정량분석하기 위한 전류측정 방법에 있어서, 상기 시료를, 필요에 따라 상기 분석물을 상기 반응성 효소기질 종류로 전환시킨후, 상기 기질과 반응성이 있는 고정된 효소 또는 효소 혼합물을 함유하는 제 1항 내지 12항중 어느 한 항에 정의된 효소전극과 접속시켜 상기 전류를 생성시키고, 생성된 전류를 측정함을 포함하는 전류 측정방법.
  15. 제 14항에 있어서, 시료가 임상적 시료인 방법.
  16. 제 15항에 있어서, 시료가 혈액시료이고, 분석물이 클루코오스이며, 효소가 글루코오스 산화효소인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700083A 1986-05-27 1987-05-27 고정된 효소 전극 KR950004906B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8612861 1986-05-27
GB868612861A GB8612861D0 (en) 1986-05-27 1986-05-27 Immobilised enzyme biosensors
PCT/GB1987/000365 WO1987007295A1 (en) 1986-05-27 1987-05-27 Immobilised enzyme electrodes

Publications (2)

Publication Number Publication Date
KR880701290A true KR880701290A (ko) 1988-07-26
KR950004906B1 KR950004906B1 (ko) 1995-05-15

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KR1019880700083A KR950004906B1 (ko) 1986-05-27 1987-05-27 고정된 효소 전극

Country Status (17)

Country Link
US (1) US4970145A (ko)
EP (1) EP0247850B1 (ko)
KR (1) KR950004906B1 (ko)
AU (1) AU591565B2 (ko)
CA (1) CA1303132C (ko)
DE (1) DE3785485T2 (ko)
DK (1) DK173722B1 (ko)
ES (1) ES2041264T3 (ko)
FI (1) FI88515C (ko)
GB (2) GB8612861D0 (ko)
HU (1) HU202577B (ko)
IE (1) IE60371B1 (ko)
IL (1) IL82601A (ko)
MX (1) MX171340B (ko)
NO (1) NO176920C (ko)
RU (1) RU1801119C (ko)
WO (1) WO1987007295A1 (ko)

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* Cited by examiner, † Cited by third party
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