KR880002232B1 - 퀴놀린 유도체와 그 염의 제조방법 - Google Patents

퀴놀린 유도체와 그 염의 제조방법 Download PDF

Info

Publication number
KR880002232B1
KR880002232B1 KR8203141A KR820003141A KR880002232B1 KR 880002232 B1 KR880002232 B1 KR 880002232B1 KR 8203141 A KR8203141 A KR 8203141A KR 820003141 A KR820003141 A KR 820003141A KR 880002232 B1 KR880002232 B1 KR 880002232B1
Authority
KR
South Korea
Prior art keywords
group
hydroxy
quinoline
formula
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8203141A
Other languages
English (en)
Korean (ko)
Other versions
KR840000501A (ko
Inventor
르 마르뜨리뜨 오디르
훔베르뜨 다니엘
프랑시스 헌뜨 베떼르
Original Assignee
허버트 후리텔
로우셀 우크라프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 허버트 후리텔, 로우셀 우크라프 filed Critical 허버트 후리텔
Publication of KR840000501A publication Critical patent/KR840000501A/ko
Application granted granted Critical
Publication of KR880002232B1 publication Critical patent/KR880002232B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Quinoline Compounds (AREA)
KR8203141A 1981-07-17 1982-07-14 퀴놀린 유도체와 그 염의 제조방법 Expired KR880002232B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8113957A FR2509728A1 (fr) 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR81-13957 1981-07-17

Publications (2)

Publication Number Publication Date
KR840000501A KR840000501A (ko) 1984-02-22
KR880002232B1 true KR880002232B1 (ko) 1988-10-20

Family

ID=9260604

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203141A Expired KR880002232B1 (ko) 1981-07-17 1982-07-14 퀴놀린 유도체와 그 염의 제조방법

Country Status (13)

Country Link
US (1) US4450167A (enExample)
EP (1) EP0070767B1 (enExample)
JP (1) JPS5818361A (enExample)
KR (1) KR880002232B1 (enExample)
AT (1) ATE12635T1 (enExample)
AU (1) AU552147B2 (enExample)
CA (1) CA1204441A (enExample)
DE (1) DE3262985D1 (enExample)
ES (1) ES514053A0 (enExample)
FI (1) FI77654C (enExample)
FR (1) FR2509728A1 (enExample)
HU (1) HU186561B (enExample)
ZA (1) ZA824746B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564832B1 (fr) * 1984-05-23 1987-05-15 Panmedica Sa Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant
ZA854556B (en) * 1984-06-25 1986-08-27 Roussel Uclaf Derivatives of isoxazoloquinolinone,process and intermediates for preparation,use as medicaments,and compositions containing them
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
EP0172004B1 (en) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, process for their preparation and pharmaceutical compositions containing them
FR2585356B1 (fr) * 1985-07-25 1987-10-23 Roussel Uclaf Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant
FR2593811B1 (fr) * 1986-01-24 1989-03-31 Sanofi Sa Derives alcoyl-1 oxo-4 dihydro-1,4 quinoleine carboxamide-3, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
FR2593810B1 (fr) * 1986-01-24 1988-04-22 Sanofi Sa Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
WO1997048694A1 (en) 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
US6429207B1 (en) * 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
EP1037878A2 (en) * 1997-11-21 2000-09-27 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
ES2227893T3 (es) 1997-12-03 2005-04-01 Taisho Pharmaceutical Co., Ltd Derivados de 1,2-dihidro-2-oxoquinolina.
JP2001526265A (ja) * 1997-12-22 2001-12-18 ファルマシア・アンド・アップジョン・カンパニー 抗ウイルス剤としての４−ヒドロキシキノリン−３−カルボキサミドおよびヒドラジド
ATE296290T1 (de) 1998-02-26 2005-06-15 Neurogen Corp Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
PL2489659T3 (pl) * 2004-06-24 2018-06-29 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą atp
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
SI2349263T1 (sl) * 2008-10-23 2014-09-30 Vertex Pharmaceuticals Incorporated Modulatorji cistiäśno-fibroznega transmembranskega regulatorja prevodnosti
EP3330255B1 (en) 2009-03-20 2020-12-09 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
RU2595894C2 (ru) 2010-08-27 2016-08-27 Грюненталь Гмбх Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3
HUE024870T2 (en) 2010-08-27 2016-02-29 Gruenenthal Gmbh Substituted 2-oxo and 2-thioxo-dihydroquinoline-3-carboxamides as modulators of KCNQ2 / 3
CA2804824A1 (en) 2010-08-27 2012-03-01 Gruenenthal Gmbh Substituted quinoline-3-carboxamides as kcnq2/3 modulators
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
IL311180A (en) 2012-02-27 2024-04-01 Vertex Pharma Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
JP2020529432A (ja) 2017-08-04 2020-10-08 アキシャル バイオセラピューティクス, インク.Axial Biotherapeutics, Inc. 微生物により誘発されるアミロイドの阻害剤
GB202016245D0 (en) * 2020-10-13 2020-11-25 Univ College Cardiff Consultants Ltd Compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR960299A (enExample) * 1950-04-15
DE540697C (de) * 1925-08-11 1933-01-28 Chemische Ind Ges Verfahren zur Darstellung einseitig acylierter Diamine
US2504896A (en) * 1945-06-04 1950-04-18 Us Sec War Method of preparing intermediates suitable for conversion into nuclear substituted heterocyclic compounds
US2504875A (en) * 1945-06-04 1950-04-18 Us Sec War Method for producing 4-hydroxyquinolines
US2614121A (en) * 1946-03-01 1952-10-14 Charles C Price Process for making intermediates for producing basic compounds
US2798070A (en) * 1954-02-04 1957-07-02 Mcneilab Inc Quaternary quinoline carboxamide salts and method of preparing same
DE1908548A1 (de) * 1968-02-29 1970-11-05 Warner Lambert Co Chinolinderivate
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
FR2221126B2 (enExample) * 1973-03-12 1977-01-28 Roussel Uclaf
CH578536A5 (en) * 1973-05-11 1976-08-13 Ciba Geigy Ag Quinoline-3-carboxylic acid derivs - with e.g. analgesic, antinociceptive, antiinflammatory and antiallergic props
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
JPS5291876A (en) * 1976-01-27 1977-08-02 Roussel Uclaf Novel derivatives of 33quinolinecarboxylic acid and medicine comprising same
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2730061A1 (de) * 1977-07-02 1979-01-18 Bayer Ag Verfahren zur herstellung von chinolin-derivaten
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2854190C2 (de) * 1978-12-15 1980-11-27 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von lasierenden Pigmentformen des Indanthrens und des chlorierten Indanthrone

Also Published As

Publication number Publication date
EP0070767B1 (fr) 1985-04-10
ES8305335A1 (es) 1983-04-01
JPS5818361A (ja) 1983-02-02
EP0070767A1 (fr) 1983-01-26
KR840000501A (ko) 1984-02-22
FI77654C (fi) 1989-04-10
FI822509A0 (fi) 1982-07-14
AU552147B2 (en) 1986-05-22
US4450167A (en) 1984-05-22
CA1204441A (fr) 1986-05-13
ATE12635T1 (de) 1985-04-15
AU8611882A (en) 1983-01-20
ES514053A0 (es) 1983-04-01
FR2509728B1 (enExample) 1985-03-01
HU186561B (en) 1985-08-28
ZA824746B (en) 1983-04-27
FR2509728A1 (fr) 1983-01-21
FI822509L (fi) 1983-01-18
DE3262985D1 (en) 1985-05-15
FI77654B (fi) 1988-12-30

Similar Documents

Publication Publication Date Title
KR880002232B1 (ko) 퀴놀린 유도체와 그 염의 제조방법
Cain et al. Potential antitumor agents. 16. 4'-(Acridin-9-ylamino) methanesulfonanilides
EP0258755B1 (en) Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments
US4675319A (en) Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use
US4020072A (en) 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines
BG61367B2 (bg) Циклоалкилтриазоли
JP3238397B2 (ja) 新規のスルホニル化合物
DK155327B (da) Analogifremgangsmaade til fremstilling af 5h-2,3-benzodiazepinderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf
JPS6331465B2 (enExample)
JPH0347179A (ja) Ｎ―ヘテロアリール―４―キノリンアミンおよびその製造法
JPH0240657B2 (ja) 3*44jihidorokarubosuchirirujudotai
EP0198456A2 (en) 1,7-Naphthyridine derivatives and medicinal preparations containing same
US4243666A (en) 4-Amino-2-piperidino-quinazolines
CS238624B2 (en) Production method of chinoline derivatives
FR2537140A1 (fr) Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
JP2909151B2 (ja) ピリドベンゾインドール、その製造方法及びそれを含有する組成物
KR880001738B1 (ko) 이미다조 /1,2-a/퀴놀린 유도체의 제조방법
EP0073645B1 (en) 2-cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester derivatives, process for the preparation thereof and composition containing the same
US4607040A (en) Quinoline derivatives which are 5-hydroxytryptamine antagonists
RU2155765C2 (ru) Производные 1,4-дигидропиридина с циклическим мостиком в положениях 1,2 в форме смеси их изомеров
US4771052A (en) Tetrahydropyrido[3',4':4,5]pyrrolo[2,3-c]quinolines and their use as hypotensive agents
CS264293B2 (en) Process for preparing derivatives of 3-/hydroxymethyl/-isoquinoline
KR880001298B1 (ko) 벤조일-페닐-피페리딘 유도체의 제법
JPH0710863B2 (ja) エーテル化若しくはエステル化しうるジヒドロキシ基により位置２で置換された４―ｏｈキノリンカルボン酸の新規の誘導体、その製造方法、及び医薬としてのその使用
JPH0121828B2 (enExample)

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19911021

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19911021