FR2509728B1 - - Google Patents

Info

Publication number
FR2509728B1
FR2509728B1 FR8113957A FR8113957A FR2509728B1 FR 2509728 B1 FR2509728 B1 FR 2509728B1 FR 8113957 A FR8113957 A FR 8113957A FR 8113957 A FR8113957 A FR 8113957A FR 2509728 B1 FR2509728 B1 FR 2509728B1
Authority
FR
France
Prior art keywords
carbon atoms
group
alkyl
hydrogen
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8113957A
Other languages
English (en)
French (fr)
Other versions
FR2509728A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8113957A priority Critical patent/FR2509728A1/fr
Priority to ZA824746A priority patent/ZA824746B/xx
Priority to AT82401317T priority patent/ATE12635T1/de
Priority to EP82401317A priority patent/EP0070767B1/fr
Priority to DE8282401317T priority patent/DE3262985D1/de
Priority to FI822509A priority patent/FI77654C/fi
Priority to KR8203141A priority patent/KR880002232B1/ko
Priority to US06/398,575 priority patent/US4450167A/en
Priority to JP57122246A priority patent/JPS5818361A/ja
Priority to CA000407411A priority patent/CA1204441A/fr
Priority to AU86118/82A priority patent/AU552147B2/en
Priority to HU822323A priority patent/HU186561B/hu
Priority to ES514053A priority patent/ES514053A0/es
Publication of FR2509728A1 publication Critical patent/FR2509728A1/fr
Application granted granted Critical
Publication of FR2509728B1 publication Critical patent/FR2509728B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Quinoline Compounds (AREA)
FR8113957A 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant Granted FR2509728A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR8113957A FR2509728A1 (fr) 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
ZA824746A ZA824746B (en) 1981-07-17 1982-07-02 Quinoline derivatives, their salts, their preparation their use as medicaments and the compositions containing them
EP82401317A EP0070767B1 (fr) 1981-07-17 1982-07-12 Nouveaux dérivés de la quinoléine, leurs sels, leur préparation, leur application comme médicaments et les compositions les renfermant
DE8282401317T DE3262985D1 (en) 1981-07-17 1982-07-12 Quinoline derivatives, their salts, their preparation, their use as medicines and compositions containing them
AT82401317T ATE12635T1 (de) 1981-07-17 1982-07-12 Chinolinderivate, ihre salze, ihre herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
KR8203141A KR880002232B1 (ko) 1981-07-17 1982-07-14 퀴놀린 유도체와 그 염의 제조방법
FI822509A FI77654C (fi) 1981-07-17 1982-07-14 Foerfarande foer framstaellning av nya kinolinderivat, vilka aer anvaendbara saosom anxiolyter.
US06/398,575 US4450167A (en) 1981-07-17 1982-07-15 3-Quinoline carboxamides having anxiolytic activity
JP57122246A JPS5818361A (ja) 1981-07-17 1982-07-15 キノリンの新誘導体及びその塩、それらの製造法、それらの薬剤としての使用並びにこれらを含む組成物
CA000407411A CA1204441A (fr) 1981-07-17 1982-07-16 Procede de preparation de nouveaux derives de la quinoleine et de leurs sels
AU86118/82A AU552147B2 (en) 1981-07-17 1982-07-16 Quinoline derivatives
HU822323A HU186561B (en) 1981-07-17 1982-07-16 Process for preparing new quinoline derivatives and salts thereof
ES514053A ES514053A0 (es) 1981-07-17 1982-07-16 "procedimiento de preparacion de nuevos derivados de la quinoleina".

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8113957A FR2509728A1 (fr) 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
FR2509728A1 FR2509728A1 (fr) 1983-01-21
FR2509728B1 true FR2509728B1 (enExample) 1985-03-01

Family

ID=9260604

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8113957A Granted FR2509728A1 (fr) 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Country Status (13)

Country Link
US (1) US4450167A (enExample)
EP (1) EP0070767B1 (enExample)
JP (1) JPS5818361A (enExample)
KR (1) KR880002232B1 (enExample)
AT (1) ATE12635T1 (enExample)
AU (1) AU552147B2 (enExample)
CA (1) CA1204441A (enExample)
DE (1) DE3262985D1 (enExample)
ES (1) ES514053A0 (enExample)
FI (1) FI77654C (enExample)
FR (1) FR2509728A1 (enExample)
HU (1) HU186561B (enExample)
ZA (1) ZA824746B (enExample)

Families Citing this family (37)

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FR2564832B1 (fr) * 1984-05-23 1987-05-15 Panmedica Sa Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant
ZA854556B (en) * 1984-06-25 1986-08-27 Roussel Uclaf Derivatives of isoxazoloquinolinone,process and intermediates for preparation,use as medicaments,and compositions containing them
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
EP0172004B1 (en) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, process for their preparation and pharmaceutical compositions containing them
FR2585356B1 (fr) * 1985-07-25 1987-10-23 Roussel Uclaf Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant
FR2593811B1 (fr) * 1986-01-24 1989-03-31 Sanofi Sa Derives alcoyl-1 oxo-4 dihydro-1,4 quinoleine carboxamide-3, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
FR2593810B1 (fr) * 1986-01-24 1988-04-22 Sanofi Sa Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
WO1997048694A1 (en) 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
US6429207B1 (en) * 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
EP1037878A2 (en) * 1997-11-21 2000-09-27 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
ES2227893T3 (es) 1997-12-03 2005-04-01 Taisho Pharmaceutical Co., Ltd Derivados de 1,2-dihidro-2-oxoquinolina.
JP2001526265A (ja) * 1997-12-22 2001-12-18 ファルマシア・アンド・アップジョン・カンパニー 抗ウイルス剤としての４−ヒドロキシキノリン−３−カルボキサミドおよびヒドラジド
ATE296290T1 (de) 1998-02-26 2005-06-15 Neurogen Corp Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
PL2489659T3 (pl) * 2004-06-24 2018-06-29 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą atp
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
SI2349263T1 (sl) * 2008-10-23 2014-09-30 Vertex Pharmaceuticals Incorporated Modulatorji cistiäśno-fibroznega transmembranskega regulatorja prevodnosti
EP3330255B1 (en) 2009-03-20 2020-12-09 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
RU2595894C2 (ru) 2010-08-27 2016-08-27 Грюненталь Гмбх Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3
HUE024870T2 (en) 2010-08-27 2016-02-29 Gruenenthal Gmbh Substituted 2-oxo and 2-thioxo-dihydroquinoline-3-carboxamides as modulators of KCNQ2 / 3
CA2804824A1 (en) 2010-08-27 2012-03-01 Gruenenthal Gmbh Substituted quinoline-3-carboxamides as kcnq2/3 modulators
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
IL311180A (en) 2012-02-27 2024-04-01 Vertex Pharma Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
JP2020529432A (ja) 2017-08-04 2020-10-08 アキシャル バイオセラピューティクス, インク.Axial Biotherapeutics, Inc. 微生物により誘発されるアミロイドの阻害剤
GB202016245D0 (en) * 2020-10-13 2020-11-25 Univ College Cardiff Consultants Ltd Compounds

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FR960299A (enExample) * 1950-04-15
DE540697C (de) * 1925-08-11 1933-01-28 Chemische Ind Ges Verfahren zur Darstellung einseitig acylierter Diamine
US2504896A (en) * 1945-06-04 1950-04-18 Us Sec War Method of preparing intermediates suitable for conversion into nuclear substituted heterocyclic compounds
US2504875A (en) * 1945-06-04 1950-04-18 Us Sec War Method for producing 4-hydroxyquinolines
US2614121A (en) * 1946-03-01 1952-10-14 Charles C Price Process for making intermediates for producing basic compounds
US2798070A (en) * 1954-02-04 1957-07-02 Mcneilab Inc Quaternary quinoline carboxamide salts and method of preparing same
DE1908548A1 (de) * 1968-02-29 1970-11-05 Warner Lambert Co Chinolinderivate
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
FR2221126B2 (enExample) * 1973-03-12 1977-01-28 Roussel Uclaf
CH578536A5 (en) * 1973-05-11 1976-08-13 Ciba Geigy Ag Quinoline-3-carboxylic acid derivs - with e.g. analgesic, antinociceptive, antiinflammatory and antiallergic props
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
JPS5291876A (en) * 1976-01-27 1977-08-02 Roussel Uclaf Novel derivatives of 33quinolinecarboxylic acid and medicine comprising same
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2730061A1 (de) * 1977-07-02 1979-01-18 Bayer Ag Verfahren zur herstellung von chinolin-derivaten
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2854190C2 (de) * 1978-12-15 1980-11-27 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von lasierenden Pigmentformen des Indanthrens und des chlorierten Indanthrone

Also Published As

Publication number Publication date
EP0070767B1 (fr) 1985-04-10
ES8305335A1 (es) 1983-04-01
JPS5818361A (ja) 1983-02-02
EP0070767A1 (fr) 1983-01-26
KR840000501A (ko) 1984-02-22
FI77654C (fi) 1989-04-10
FI822509A0 (fi) 1982-07-14
AU552147B2 (en) 1986-05-22
US4450167A (en) 1984-05-22
CA1204441A (fr) 1986-05-13
ATE12635T1 (de) 1985-04-15
AU8611882A (en) 1983-01-20
ES514053A0 (es) 1983-04-01
HU186561B (en) 1985-08-28
ZA824746B (en) 1983-04-27
FR2509728A1 (fr) 1983-01-21
FI822509L (fi) 1983-01-18
DE3262985D1 (en) 1985-05-15
FI77654B (fi) 1988-12-30
KR880002232B1 (ko) 1988-10-20

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Legal Events

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ST Notification of lapse