KR870003772A - 2-(2-플루오로-4-비페닐릴)프로피온산을 함유하는 약제학적 조성물의 제조방법 - Google Patents

2-(2-플루오로-4-비페닐릴)프로피온산을 함유하는 약제학적 조성물의 제조방법 Download PDF

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Publication number
KR870003772A
KR870003772A KR1019860008273A KR860008273A KR870003772A KR 870003772 A KR870003772 A KR 870003772A KR 1019860008273 A KR1019860008273 A KR 1019860008273A KR 860008273 A KR860008273 A KR 860008273A KR 870003772 A KR870003772 A KR 870003772A
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South Korea
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biphenylyl
fluoro
pharmaceutical composition
propionic acid
fatty acid
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KR1019860008273A
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KR940000231B1 (ko
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버드 그라함
스미드 알란
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데레크 노만 에드먼드슨
더 부츠 캄파니 피엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

내용 없음

Description

2-(2-플루오로-4-비페닐릴)프로피온산을 함유하는 약제학적 조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 용융된 형태의 지방산에스테르 부형제에 2-(2-플루오로-4-비페닐릴)프로피온산 교반하면서 가하여 균질용액 또는 분산액을 형성시키고, 조성물을 고화시키는 단계로 이루어지는, 2-(2-플루오르-4-비페닐릴)프로피온산 또는 그의 약제학적으로 허용되는 염 및, 하나 또는 그 이상의 천연식물유 지방산의 폴리올에스테르 및 글리세리드로 이루어지며 융점이 55℃ 미만이고 HLB치가 적어도 10인 지방산 에스테르부형체로 구성되는 약제학적 조성물의 제조방법.
  2. 제1항에 있어서, 지방산 에스테르 부형체가 적어도 12의 HLB치를 갖는 방법.
  3. 제1항 및 2항중 어느 한 항에 있어서, 지방산 에스테르 부형제가 적어도 14의 HLB치를 갖는 방법.
  4. 제1항 내지 3항중 어느 한항에 있어서, 지방산 에스테르 부형제가 30내지 50℃범위의 음절을 갖는 방법.
  5. 제1 내지 4항중 어느 한 항에 있어서, 약제학적 조성물이 33내지 46℃범위의 융점을 갖는 방법.
  6. 제1 내지 5항중 어느 한항에 있어서, 천연 식물유지방산이 C18-22지방산으로 이루어지는 방법.
  7. 제1 내지 6항중 어느 한항에 있어서, 폴리올 에스테르가 폴리에틸렌 글리콜의 에스테르로 이루어지는 방법.
  8. 제1 내지 7항중 어느 한 항에 있어서, 2-(2-플루오로-4-비페닐릴)프로피온산이 조성물의 40중량%이하를 차지하는 방법.
  9. 제1 내지 8항중 어느 한 항에 있어서, 약제학적 조성물의 플루비프로펜을 함유하는 방법.
  10. 제1 내지 8항중 어느 한 항에 있어서, 약제학적 조성물이 2-(2-플루오로-4-비페닐릴)프로피온산의 나트륨염을 함유하는 방법.
  11. 제1 내지 10항중 어느 한 항에 있어서, 약제학적 조성물이 경질젤라틴 캅셀제의 형태로 존재하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008273A 1985-10-03 1986-10-02 2-(2-플루오로-4-비페닐릴)프로피온산을 함유하는 약제학적 조성물의 제조방법 KR940000231B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB85-24421 1985-10-03
GB858524421A GB8524421D0 (en) 1985-10-03 1985-10-03 Therapeutic agents
GB8524421 1985-10-03

Publications (2)

Publication Number Publication Date
KR870003772A true KR870003772A (ko) 1987-05-04
KR940000231B1 KR940000231B1 (ko) 1994-01-12

Family

ID=10586136

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008273A KR940000231B1 (ko) 1985-10-03 1986-10-02 2-(2-플루오로-4-비페닐릴)프로피온산을 함유하는 약제학적 조성물의 제조방법

Country Status (22)

Country Link
US (1) US4786495A (ko)
EP (1) EP0223369B1 (ko)
JP (1) JPS62111922A (ko)
KR (1) KR940000231B1 (ko)
AT (1) ATE59291T1 (ko)
AU (1) AU594264B2 (ko)
CA (1) CA1275930C (ko)
CS (1) CS271463B2 (ko)
DE (1) DE3676645D1 (ko)
DK (1) DK165165C (ko)
EG (1) EG17609A (ko)
ES (1) ES2033682T3 (ko)
FI (1) FI84314C (ko)
GB (1) GB8524421D0 (ko)
GR (1) GR3001312T3 (ko)
IE (1) IE59134B1 (ko)
IN (1) IN164030B (ko)
NO (1) NO173046C (ko)
NZ (1) NZ217703A (ko)
PT (1) PT83474B (ko)
RU (1) RU1800996C (ko)
ZA (1) ZA867309B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8630273D0 (en) * 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
GB8701392D0 (en) * 1987-01-22 1987-02-25 Boots Co Plc Therapeutic agents
US5240712A (en) * 1987-07-17 1993-08-31 The Boots Company Plc Therapeutic agents
US5286751A (en) * 1987-12-24 1994-02-15 Analgesic Associates Sustained/enhanced antipyretic response
US4980175A (en) * 1989-01-03 1990-12-25 Leonard Chavkin Liquid orally administrable compositions based on edible oils
US5189066A (en) * 1989-11-22 1993-02-23 The Procter & Gamble Company Pharmaceutical compositions of tebufelone
US5681964A (en) * 1990-10-23 1997-10-28 University Of Kentucky Research Foundation Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
DE4140172C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Ibuprofen enthaltendes Arzneimittel
DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DE4140183C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Flurbiprofen enthaltendes Arzneimittel
DE4140184C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Flurbiprofen enthaltendes Arzneimittel
US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
GB9325445D0 (en) * 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5545628A (en) † 1995-01-10 1996-08-13 Galephar P.R. Inc. Pharmaceutical composition containing fenofibrate
ATE232087T1 (de) * 1997-10-27 2003-02-15 Merck Patent Gmbh Feste lösungen und dispersionen von eines schlecht wasserlöslichen wirkstoffes
FR2775188B1 (fr) * 1998-02-23 2001-03-09 Lipha Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption
FR2775597B1 (fr) * 1998-03-04 2001-04-20 Gattefosse Ets Sa Pellet administrable par voie orale apte a ameliorer la biodisponibilite de la substance active, procede de fabrication
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
ITMI20011338A1 (it) * 2001-06-26 2002-12-26 Farmatron Ltd Composizioni farmaceutiche orali a rilascio immediato del principio attivo
DK1521572T3 (da) * 2002-07-15 2009-05-04 Alcon Inc Biologisk nedbrydelig film til indförsel af öjenlægemiddel
CA2491313C (en) 2002-07-15 2011-05-24 Alcon, Inc. Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use
AU2003280960A1 (en) * 2002-07-15 2004-02-02 Alcon, Inc. Pharmaceutical compositions for otic use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1274354A (fr) * 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
US3966978A (en) * 1975-04-25 1976-06-29 American Cyanamid Company 4-Biphenylacetic acid as an inhibitor of platelet aggregation
SE445174B (sv) * 1978-03-07 1986-06-09 Sandoz Ag Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
JPS57171912A (en) * 1981-04-14 1982-10-22 Sumitomo Chem Co Ltd Cream
JPS5913720A (ja) * 1982-07-15 1984-01-24 Green Cross Corp:The フルルビプロフエン脂肪乳剤
US4477468A (en) * 1982-12-06 1984-10-16 The Upjohn Company Treatment of type II herpes virus with flurbiprofen
IT1170238B (it) * 1982-12-06 1987-06-03 Upjohn Co Impiego di ibuprofene e flurbiprofene nella cura dell'erpete
US4473584A (en) * 1982-12-06 1984-09-25 The Upjohn Company Treatment of Type I Herpes virus with flurbiprofen
JPS59122425A (ja) * 1982-12-27 1984-07-14 Kaken Pharmaceut Co Ltd 持続性製剤およびその製造法
JPS601122A (ja) * 1983-06-20 1985-01-07 Green Cross Corp:The ビフエニリルプロピオン酸誘導体脂肪乳剤
US4543251A (en) * 1983-12-09 1985-09-24 Toko Yakuhin Industry Co., Ltd. Gel preparations for external application
IT1191608B (it) * 1985-02-01 1988-03-23 Zambon Spa Composizione farmaceutica e forme farmaceutiche che la contengono
EP0212747B1 (en) * 1985-08-16 1991-04-10 The Procter & Gamble Company Drug particles having constant release and immediate release
EP0275526A3 (en) * 1986-12-27 1990-01-31 Banyu Pharmaceutical Co., Ltd. Composition for administration through a body cavity

Also Published As

Publication number Publication date
GB8524421D0 (en) 1985-11-06
IE862449L (en) 1987-04-03
KR940000231B1 (ko) 1994-01-12
NO173046B (no) 1993-07-12
NO863935D0 (no) 1986-10-02
CA1275930C (en) 1990-11-06
NZ217703A (en) 1989-01-06
CS271463B2 (en) 1990-10-12
US4786495A (en) 1988-11-22
DK165165C (da) 1993-03-01
CS708386A2 (en) 1990-02-12
FI863976A (fi) 1987-04-04
AU594264B2 (en) 1990-03-01
NO173046C (no) 1993-10-20
RU1800996C (ru) 1993-03-07
FI863976A0 (fi) 1986-10-01
PT83474A (en) 1986-11-01
DK453386D0 (da) 1986-09-23
JPH0428243B2 (ko) 1992-05-13
ES2033682T3 (es) 1993-04-01
FI84314B (fi) 1991-08-15
EP0223369A3 (en) 1987-12-02
FI84314C (fi) 1991-11-25
ATE59291T1 (de) 1991-01-15
EP0223369A2 (en) 1987-05-27
IN164030B (ko) 1988-12-31
PT83474B (pt) 1989-02-28
DK453386A (da) 1987-04-04
DE3676645D1 (de) 1991-02-07
IE59134B1 (en) 1994-01-12
AU6346586A (en) 1987-04-09
EP0223369B1 (en) 1990-12-27
ZA867309B (en) 1987-05-27
DK165165B (da) 1992-10-19
EG17609A (en) 1995-04-30
NO863935L (no) 1987-04-06
GR3001312T3 (en) 1992-08-31
JPS62111922A (ja) 1987-05-22

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