KR870000920B1 - 벤조 치오펜 유도체의 제조 방법 - Google Patents

벤조 치오펜 유도체의 제조 방법 Download PDF

Info

Publication number
KR870000920B1
KR870000920B1 KR1019850001704A KR850001704A KR870000920B1 KR 870000920 B1 KR870000920 B1 KR 870000920B1 KR 1019850001704 A KR1019850001704 A KR 1019850001704A KR 850001704 A KR850001704 A KR 850001704A KR 870000920 B1 KR870000920 B1 KR 870000920B1
Authority
KR
South Korea
Prior art keywords
dimethoxy
benzo
melting point
thiopene
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850001704A
Other languages
English (en)
Korean (ko)
Other versions
KR850006391A (ko
Inventor
레드패드 제임스
토마스 로간 로버트
브룬톤 맥파젠 다비드
깁슨로이 로버트
Original Assignee
아크조 엔. 브이.
에이. 디. 도우마 프록시
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아크조 엔. 브이., 에이. 디. 도우마 프록시 filed Critical 아크조 엔. 브이.
Publication of KR850006391A publication Critical patent/KR850006391A/ko
Application granted granted Critical
Publication of KR870000920B1 publication Critical patent/KR870000920B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1019850001704A 1984-03-16 1985-03-16 벤조 치오펜 유도체의 제조 방법 Expired KR870000920B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848406906A GB8406906D0 (en) 1984-03-16 1984-03-16 Benzo-thiazole and benzothiophene derivatives
GB84.06906 1984-03-16

Publications (2)

Publication Number Publication Date
KR850006391A KR850006391A (ko) 1985-10-05
KR870000920B1 true KR870000920B1 (ko) 1987-05-07

Family

ID=10558202

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001704A Expired KR870000920B1 (ko) 1984-03-16 1985-03-16 벤조 치오펜 유도체의 제조 방법

Country Status (14)

Country Link
US (2) US4665206A (enExample)
EP (1) EP0158380B1 (enExample)
JP (1) JPS60209577A (enExample)
KR (1) KR870000920B1 (enExample)
AU (1) AU568428B2 (enExample)
CA (1) CA1254216A (enExample)
DE (1) DE3567459D1 (enExample)
DK (1) DK119285A (enExample)
ES (4) ES8707223A1 (enExample)
FI (1) FI80883C (enExample)
GB (1) GB8406906D0 (enExample)
HU (1) HU198030B (enExample)
IE (1) IE57977B1 (enExample)
ZA (1) ZA851807B (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity
EP0253650A3 (en) * 1986-07-18 1989-09-13 Eli Lilly And Company Improvements relating to benzothiophene derivatives
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
DE68901424D1 (de) * 1988-07-05 1992-06-11 Akzo Nv Verbindungen mit bronchodilatatorischer aktivitaet.
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
DE4128871A1 (de) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
AU683552B2 (en) * 1994-04-11 1997-11-13 Chugai Seiyaku Kabushiki Kaisha 4,6-DI-t-butyl-2,3-dihydrobenzothiophene derivative
US5760062A (en) * 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5770613A (en) * 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) * 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
TR199901280T2 (xx) * 1996-12-13 1999-10-21 Shionogi & Co., Ltd. Benzotiofenekarboksamid t�revleri ve bunlar� i�eren PGD2 antagonistleri.
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
CN1520313A (zh) 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
WO2005034880A2 (en) * 2003-10-09 2005-04-21 Aton Pharma, Inc. Thiophene and benzothiophene hydroxamic acid derivatives
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
CA2643012A1 (en) * 2006-02-21 2007-08-30 Trigen Limited Heterocyclic compounds and their use in the treatment of cardiovascular disease
EP2079694B1 (en) 2006-12-28 2017-03-01 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN111296447B (zh) * 2020-03-24 2021-09-17 东营施普瑞石油工程技术有限公司 一种油田用杀菌剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB438211A (en) * 1934-06-01 1935-11-13 Ig Farbenindustrie Ag The manufacture of heterocyclic compounds
US2775593A (en) * 1948-10-01 1956-12-25 Schenley Ind Inc Thiosemicarbazones of aldehydes and ketones of the heterocyclic series
GB1229580A (enExample) * 1967-12-15 1971-04-28
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
BE786520A (fr) * 1971-07-23 1973-01-22 Bayer Ag Nouveaux benzothiazoles substitues, leur preparation et leur application comme fongicides et bactericides
DE2258036A1 (de) * 1972-11-27 1974-05-30 Goedecke Ag Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten
FR2305982A1 (fr) * 1975-04-03 1976-10-29 Innothera Lab Sa Nouvelles benzothienyl amino (propyl et butyl) cetones, leur procede de preparation et leur application en therapeutique
CH636866A5 (de) * 1977-08-15 1983-06-30 Lilly Co Eli Thiadiazolylbenzamide und sie enthaltende insektizide mittel.
US4140785A (en) * 1978-05-08 1979-02-20 E. I. Du Pont De Nemours And Company N-(benzothienopyrazol)amide antirhinoviral agents
JPS5936670A (ja) * 1982-08-25 1984-02-28 Takeda Chem Ind Ltd ベンゾチアゾ−ル誘導体，その製造法およびそれを含有する摂食抑制剤

Also Published As

Publication number Publication date
FI80883C (fi) 1990-08-10
HU198030B (en) 1989-07-28
JPH0588232B2 (enExample) 1993-12-21
US4665206A (en) 1987-05-12
FI851038A0 (fi) 1985-03-15
GB8406906D0 (en) 1984-04-18
DK119285A (da) 1985-09-17
EP0158380A1 (en) 1985-10-16
CA1254216A (en) 1989-05-16
HUT37410A (en) 1985-12-28
ES8704924A1 (es) 1987-04-16
IE57977B1 (en) 1993-06-02
DE3567459D1 (en) 1989-02-16
ES8704925A1 (es) 1987-04-16
JPS60209577A (ja) 1985-10-22
EP0158380B1 (en) 1989-01-11
DK119285D0 (da) 1985-03-15
KR850006391A (ko) 1985-10-05
US4929636A (en) 1990-05-29
ES8704926A1 (es) 1987-04-16
AU568428B2 (en) 1987-12-24
ES8707223A1 (es) 1987-07-16
FI851038L (fi) 1985-09-17
ES551280A0 (es) 1987-04-16
ZA851807B (en) 1985-10-30
ES551282A0 (es) 1987-04-16
IE850592L (en) 1985-09-16
AU3985285A (en) 1985-09-19
ES551281A0 (es) 1987-04-16
FI80883B (fi) 1990-04-30
ES541336A0 (es) 1987-07-16

Similar Documents

Publication Publication Date Title
KR870000920B1 (ko) 벤조 치오펜 유도체의 제조 방법
US4424231A (en) Compounds
KR900003496B1 (ko) 티에닐 축합 피라졸 유도체의 제조방법
US3420851A (en) Novel dibenzoxepines
US4163794A (en) 2,3-Dihydro-6,7-disubstituted-5-furoyl benzofuran-2-carboxylic acids
IE912224A1 (en) "New 4-aminobutyric acid compounds, process for the preparation thereof and pharmaceutical preparations containing them"
FI80691C (fi) Foerfarande foer framstaellning av bensotiofener och bensofuraner med antiallergisk aktivitet.
US6090837A (en) Substituted hydrochromenopyrroles
US4705782A (en) Indene and naphthalene derivatives
JPS6159313B2 (enExample)
US5049559A (en) Thieno-triazolo-diazepine derivatives useful as anti-ischemic agents
US4181727A (en) 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
CA1338419C (en) Substituted thienopyrans as antihypertensive agents
US4952571A (en) Pyridazinone derivatives
FI66857B (fi) Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara 3-substituerade dibensofuranderivat
PT745584E (pt) Compostos de arilalquil(tio)-carboxamidas tendo uma afinidade para receptores melatoninergicos processos para a sua preparacao e composicoes farmaceuticas que os contem
CH680589A5 (enExample)
Deprets et al. Synthesis of 5‐Methylbenzo [b] thieno [2, 3‐c] isoquinolines and5‐Methylbenzo [b] seleno [2, 3‐c] isoquinolines
Ceccarelli et al. Synthesis of novel 2‐substituted‐5‐oxycoumarans via A direct route to 2, 3‐dihydro‐5‐hydroxy‐2‐benzofuranacetic acids
US5019573A (en) Substituted dibenzofurans and methods of using same
US5021449A (en) Organic compounds and their use as pharmaceuticals
CA1276158C (en) 4h-benzo[4,5]cyclohepta[1,2-b]thiophene derivatives
FI69461B (fi) Analogifoerfarande foer framstaellning av nya saosom laekemedelsaktivaemnen anvaendbara bensotiofen-2-on-3-karboxamider
SU1145931A3 (ru) Способ получени производных 5,6,7,7а-тетрагидро-4 @ -тиено/3,2- @ /-пиридинона-2 или их солей
US5015656A (en) Organic compounds and their use as pharmaceuticals

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

FPAY Annual fee payment

Payment date: 19980420

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19990508

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19990508

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301