KR860700353A - 1-히드록시비타민 d 화합물의 제조방법 - Google Patents

1-히드록시비타민 d 화합물의 제조방법

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Publication number
KR860700353A
KR860700353A KR860700400A KR860700400A KR860700353A KR 860700353 A KR860700353 A KR 860700353A KR 860700400 A KR860700400 A KR 860700400A KR 860700400 A KR860700400 A KR 860700400A KR 860700353 A KR860700353 A KR 860700353A
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KR
South Korea
Prior art keywords
cyclovitamin
compound
hydroxy
mixture
hydroxyvitamin
Prior art date
Application number
KR860700400A
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English (en)
Other versions
KR920004488B1 (ko
Inventor
에프 데루카(외 3) 헥토어
Original Assignee
원본미기재
위스콘신 알룸니 리서어치 파운데이션
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Publication of KR860700353A publication Critical patent/KR860700353A/ko
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Publication of KR920004488B1 publication Critical patent/KR920004488B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

1-히드록시비타민 D 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

1-히드록시-3,5-시클로비타민 D 화합물을 디메틸설폭시드와 유기산의 혼합물로 처리함으로써 비아실화 1-히드록시비타민 D 화합물과 그의 5,6-트란스-이성체를 혼합물로서 얻고, 임의에 따라서는, 상기 혼합물을 분리시켜 1-히드록시비타민 D 성분들 모두 또는 그중의 하나를 회수하는 것으로 구성되는, 1-히드록시비타민 D 화합물의 제조방법.
제1항에 있어서, 유기산이 초산 또는 포름산인 방법.
제1항에 있어서, 1-히드록시-3,5-시클로비타민 D 화합물이 1α-히드록시-3,5-시클로비타민 D3인 방법.
제1항에 있어서, 1-히드록시-3,5-시클로비타민 D화합물이 1α-히드록시-3,5-시클로비타민 D2인 방법.
제1항에 있어서, 1-히드록시-3,5-시클로비타민 D 화합물이 1α, 25-디히드록시-3,5-시클로비타민 D3인 방법.
제1항에 있어서, 1-히드록시-3,5-시클로비타민 D 화합물이 1α,25-디히드록시-3,5-시클로비타민 D2또는 1α, 25-디히드록시-3,5-시클로-24-에피비타민 D2인 방법.
제1항에 있어서, 5,6-시스-및 5,6-트란스-1-히드록시 비타민 D 이성체 혼합물의 분리가, 그 혼합물을 친디엔체로 처리함으로써 수행되는 방법.
제7항에 있어서, 친디엔체가 말레인산, 말레인산 모노알킬에스테르, 말레인산 디알킬에스테르, 무수말레인산, 아세틸렌디카르복실산 및 아세틸렌 알킬디카르복실레이트로 이루어진 군으로부터 선택되는 방법.
제7항에 있어서, 친디엔체가 N4-알킬 또는 페닐-치환-트리아졸린-3,5-디온, 말레이미드 및 N-알킬 또는 페닐-치환 말레이미드로 이루어진 군으로 부터 선택되는 방법.
제7항 또는 제9항에 있어서, 친디엔체로 처리함으로써 산출된 생성물 혼합물이 크로마토그라피에 의하여 분리되는 방법.
제7항 또는 제8항에 있어서, 친디엔체로 처리함으로써 산출된 생성물 혼합물이, 혼합물을 염기로 처리하고 수성 및 유기 용매 사이에서 분배시키고 원하는 1-히드록시비타민 D생성물을 유기용매 내에서 회수함으로써 분리되는 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860700400A 1984-11-01 1985-10-15 1-히드록시비타민 d 화합물의 제조방법 KR920004488B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/667,296 US4555364A (en) 1984-11-01 1984-11-01 Method for preparing 1-hydroxyvitamin D compounds
PCT/US1985/001995 WO1986002649A1 (en) 1984-11-01 1985-10-15 Method for preparing 1-hydroxyvitamin d compounds
US667296 1991-03-11
US667,296 1991-03-11

Publications (2)

Publication Number Publication Date
KR860700353A true KR860700353A (ko) 1986-10-06
KR920004488B1 KR920004488B1 (ko) 1992-06-05

Family

ID=24677643

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860700400A KR920004488B1 (ko) 1984-11-01 1985-10-15 1-히드록시비타민 d 화합물의 제조방법

Country Status (12)

Country Link
US (1) US4555364A (ko)
EP (1) EP0198892B1 (ko)
JP (1) JPS62500717A (ko)
KR (1) KR920004488B1 (ko)
AU (1) AU589580B2 (ko)
CA (1) CA1233187A (ko)
DE (1) DE3581200D1 (ko)
DK (1) DK153943C (ko)
IE (1) IE58164B1 (ko)
IL (1) IL76754A (ko)
NZ (1) NZ213844A (ko)
WO (1) WO1986002649A1 (ko)

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CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5246925A (en) * 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
US5801164A (en) * 1990-09-21 1998-09-01 Bone Care International, Inc. Methods of treating osteoporosis prophylactically or therapeutically
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US5763428A (en) * 1990-09-21 1998-06-09 Bone Care International, Inc. Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
US6025346A (en) * 1990-09-21 2000-02-15 Bone Care International, Inc. 1α-hydroxy vitamin D4 and novel intermediates and analogues
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6121469A (en) * 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US5869472A (en) * 1994-07-18 1999-02-09 Bone Care International, Inc. Synthesis of 1α-hydroxy vitamin D
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Also Published As

Publication number Publication date
AU589580B2 (en) 1989-10-19
AU4867485A (en) 1986-05-15
KR920004488B1 (ko) 1992-06-05
JPS62500717A (ja) 1987-03-26
US4555364A (en) 1985-11-26
CA1233187A (en) 1988-02-23
IE58164B1 (en) 1993-07-28
WO1986002649A1 (en) 1986-05-09
EP0198892B1 (en) 1990-12-27
IE852706L (en) 1986-05-01
NZ213844A (en) 1989-08-29
DK301986D0 (da) 1986-06-26
EP0198892A1 (en) 1986-10-29
IL76754A0 (en) 1986-02-28
EP0198892A4 (en) 1987-03-12
DK301986A (da) 1986-06-26
DK153943C (da) 1989-01-30
JPH0432062B2 (ko) 1992-05-28
DK153943B (da) 1988-09-26
IL76754A (en) 1989-10-31
DE3581200D1 (de) 1991-02-07

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