DE3581200D1 - Verfahren zur herstellung von 1-hydroxyvitamin-d-verbindungen. - Google Patents
Verfahren zur herstellung von 1-hydroxyvitamin-d-verbindungen.Info
- Publication number
- DE3581200D1 DE3581200D1 DE8585905353T DE3581200T DE3581200D1 DE 3581200 D1 DE3581200 D1 DE 3581200D1 DE 8585905353 T DE8585905353 T DE 8585905353T DE 3581200 T DE3581200 T DE 3581200T DE 3581200 D1 DE3581200 D1 DE 3581200D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxyvitamin
- compounds
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/667,296 US4555364A (en) | 1984-11-01 | 1984-11-01 | Method for preparing 1-hydroxyvitamin D compounds |
PCT/US1985/001995 WO1986002649A1 (en) | 1984-11-01 | 1985-10-15 | Method for preparing 1-hydroxyvitamin d compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3581200D1 true DE3581200D1 (de) | 1991-02-07 |
Family
ID=24677643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585905353T Expired - Lifetime DE3581200D1 (de) | 1984-11-01 | 1985-10-15 | Verfahren zur herstellung von 1-hydroxyvitamin-d-verbindungen. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4555364A (de) |
EP (1) | EP0198892B1 (de) |
JP (1) | JPS62500717A (de) |
KR (1) | KR920004488B1 (de) |
AU (1) | AU589580B2 (de) |
CA (1) | CA1233187A (de) |
DE (1) | DE3581200D1 (de) |
DK (1) | DK153943C (de) |
IE (1) | IE58164B1 (de) |
IL (1) | IL76754A (de) |
NZ (1) | NZ213844A (de) |
WO (1) | WO1986002649A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
NZ232734A (en) * | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
US5801164A (en) * | 1990-09-21 | 1998-09-01 | Bone Care International, Inc. | Methods of treating osteoporosis prophylactically or therapeutically |
US5763428A (en) * | 1990-09-21 | 1998-06-09 | Bone Care International, Inc. | Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof |
US5798345A (en) * | 1990-09-21 | 1998-08-25 | Bone Care International, Inc. | Method of inhibiting the hyperproliferation of malignant cells |
US6025346A (en) * | 1990-09-21 | 2000-02-15 | Bone Care International, Inc. | 1α-hydroxy vitamin D4 and novel intermediates and analogues |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6121469A (en) * | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
US5869472A (en) * | 1994-07-18 | 1999-02-09 | Bone Care International, Inc. | Synthesis of 1α-hydroxy vitamin D |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US6376479B1 (en) | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6929797B2 (en) * | 1997-02-13 | 2005-08-16 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
EP1301479A2 (de) * | 2000-07-18 | 2003-04-16 | Bone Care International, Inc. | Stabilisiertes 1alpha-hydroxy vitamin d |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20050239756A1 (en) * | 2004-04-23 | 2005-10-27 | Bone Care International, Inc. | Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2 |
US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
CA2624897C (en) * | 2005-10-12 | 2017-02-14 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
JP5869745B2 (ja) * | 2006-02-03 | 2016-02-24 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 25−ヒドロキシビタミンd2及び25−ヒドロキシビタミンd3によるビタミンd不足及び欠乏の治療 |
EP3659608A1 (de) | 2006-06-21 | 2020-06-03 | Opko Ireland Global Holdings, Ltd. | Therapie unter verwendung von vitamin-d-sättigungsmittel und vitamin-d-hormonersatzmittel |
CN104257667B (zh) * | 2007-04-25 | 2019-06-04 | 欧普科Ip 控股Ii 有限公司 | 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的方法和组合物 |
EP3335712A1 (de) | 2007-04-25 | 2018-06-20 | Opko Renal, LLC | Verfahren zur sicheren und effektiven behandlung und vorbeugung von sekundärem hyperparathyroidismus bei chronischer nierenerkrankung |
EP2148685A4 (de) * | 2007-04-25 | 2010-07-28 | Cytochroma Inc | Verfahren und verbindungen für die vitamin-d-therapie |
ES2956794T3 (es) | 2007-04-25 | 2023-12-28 | Eirgen Pharma Ltd | Liberación controlada de 25-hidroxivitamina D |
CN102046812A (zh) | 2008-04-02 | 2011-05-04 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
KR102125424B1 (ko) | 2010-03-29 | 2020-06-22 | 사이토크로마 인코포레이티드 | 부갑상선 수준을 낮추기 위한 방법 및 조성물 |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
SG10201911274TA (en) | 2014-08-07 | 2020-02-27 | Opko Ireland Global Holdings Ltd | Adjunctive therapy with 25-hydroxyvitamin d |
BR112018069727A2 (pt) | 2016-03-28 | 2019-02-05 | Opko Ireland Global Holdings Ltd | métodos de tratamento com vitamina d |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4234495A (en) * | 1979-09-10 | 1980-11-18 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxyvitamin D compounds from 1α-hydroxy-3,5-cyclovitamin D compounds |
US4367177A (en) * | 1981-04-15 | 1983-01-04 | Wisconsin Alumni Research Foundation | Process for preparing 23,25-dihydroxyvitamin D3 |
US4512925A (en) * | 1983-09-14 | 1985-04-23 | Wisconsin Alumini Research Foundation | 1,23-Dihydroxyvitamin D compounds |
US4554106A (en) * | 1984-11-01 | 1985-11-19 | Wisconsin Alumni Research Foundation | Method for preparing 1α-hydroxyvitamin D compounds |
-
1984
- 1984-11-01 US US06/667,296 patent/US4555364A/en not_active Expired - Lifetime
-
1985
- 1985-10-15 KR KR1019860700400A patent/KR920004488B1/ko not_active IP Right Cessation
- 1985-10-15 WO PCT/US1985/001995 patent/WO1986002649A1/en active IP Right Grant
- 1985-10-15 EP EP85905353A patent/EP0198892B1/de not_active Expired - Lifetime
- 1985-10-15 AU AU48674/85A patent/AU589580B2/en not_active Expired
- 1985-10-15 DE DE8585905353T patent/DE3581200D1/de not_active Expired - Lifetime
- 1985-10-15 JP JP60504750A patent/JPS62500717A/ja active Granted
- 1985-10-16 NZ NZ213844A patent/NZ213844A/xx unknown
- 1985-10-18 IL IL76754A patent/IL76754A/xx not_active IP Right Cessation
- 1985-10-18 CA CA000493353A patent/CA1233187A/en not_active Expired
- 1985-11-01 IE IE270685A patent/IE58164B1/en not_active IP Right Cessation
-
1986
- 1986-06-26 DK DK301986A patent/DK153943C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4867485A (en) | 1986-05-15 |
JPS62500717A (ja) | 1987-03-26 |
KR920004488B1 (ko) | 1992-06-05 |
DK153943B (da) | 1988-09-26 |
AU589580B2 (en) | 1989-10-19 |
IE58164B1 (en) | 1993-07-28 |
IE852706L (en) | 1986-05-01 |
DK301986D0 (da) | 1986-06-26 |
DK301986A (da) | 1986-06-26 |
EP0198892A1 (de) | 1986-10-29 |
IL76754A0 (en) | 1986-02-28 |
US4555364A (en) | 1985-11-26 |
EP0198892A4 (de) | 1987-03-12 |
WO1986002649A1 (en) | 1986-05-09 |
IL76754A (en) | 1989-10-31 |
CA1233187A (en) | 1988-02-23 |
DK153943C (da) | 1989-01-30 |
JPH0432062B2 (de) | 1992-05-28 |
EP0198892B1 (de) | 1990-12-27 |
KR860700353A (ko) | 1986-10-06 |
NZ213844A (en) | 1989-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |