JPS5576858A - 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation - Google Patents

24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation

Info

Publication number
JPS5576858A
JPS5576858A JP14903178A JP14903178A JPS5576858A JP S5576858 A JPS5576858 A JP S5576858A JP 14903178 A JP14903178 A JP 14903178A JP 14903178 A JP14903178 A JP 14903178A JP S5576858 A JPS5576858 A JP S5576858A
Authority
JP
Japan
Prior art keywords
fluoro
protected derivative
hydroxyvitamin
preparation
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14903178A
Other languages
Japanese (ja)
Other versions
JPS6148499B2 (en
Inventor
Yoshiro Kobayashi
Takeo Taguchi
Nobuo Ikegawa
Toru Takeshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP14903178A priority Critical patent/JPS5576858A/en
Publication of JPS5576858A publication Critical patent/JPS5576858A/en
Publication of JPS6148499B2 publication Critical patent/JPS6148499B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formula I (R is H or OH-protecting group).
USE: Drug for accelerating the absorption through the bones or absorption of calcium through the intestinal canals of mammals.
PROCESS: The compound of formula I is prepared by (1) irradiating 24-fluoro-25- hydroxycholesta-5,7-diene or its OH-protected derivative II with UV-radiation in an inert organic solvent such as hexane at -20W+120°C, pref. -10W+50°C, (2) isomerizing the resulting compound III at 20W120°C, pref. 40W100°C, and if necessary, (3) eliminating the OH-protecting group.
COPYRIGHT: (C)1980,JPO&Japio
JP14903178A 1978-12-04 1978-12-04 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation Granted JPS5576858A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14903178A JPS5576858A (en) 1978-12-04 1978-12-04 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14903178A JPS5576858A (en) 1978-12-04 1978-12-04 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation

Publications (2)

Publication Number Publication Date
JPS5576858A true JPS5576858A (en) 1980-06-10
JPS6148499B2 JPS6148499B2 (en) 1986-10-24

Family

ID=15466147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14903178A Granted JPS5576858A (en) 1978-12-04 1978-12-04 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation

Country Status (1)

Country Link
JP (1) JPS5576858A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852268A (en) * 1981-08-28 1983-03-28 エフ・ホフマン―ラ　ロシユ　アーゲー Cholecalciferol
FR2530624A1 (en) * 1982-07-26 1984-01-27 Wisconsin Alumni Res Found NOVEL ANALOGUES OF VITAMIN D AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0546114Y2 (en) * 1987-04-14 1993-12-01

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852268A (en) * 1981-08-28 1983-03-28 エフ・ホフマン―ラ　ロシユ　アーゲー Cholecalciferol
FR2530624A1 (en) * 1982-07-26 1984-01-27 Wisconsin Alumni Res Found NOVEL ANALOGUES OF VITAMIN D AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
JPS6148499B2 (en) 1986-10-24

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