JPS56122348A - 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation - Google Patents

25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation

Info

Publication number
JPS56122348A
JPS56122348A JP2519580A JP2519580A JPS56122348A JP S56122348 A JPS56122348 A JP S56122348A JP 2519580 A JP2519580 A JP 2519580A JP 2519580 A JP2519580 A JP 2519580A JP S56122348 A JPS56122348 A JP S56122348A
Authority
JP
Japan
Prior art keywords
protected derivative
compound
formula
trifluorovitamin
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2519580A
Other languages
Japanese (ja)
Other versions
JPS6228952B2 (en
Inventor
Yoshiro Kobayashi
Takeo Taguchi
Nobuo Ikegawa
Masuo Morizaki
Junichi Oshida
Toru Takeshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP2519580A priority Critical patent/JPS56122348A/en
Publication of JPS56122348A publication Critical patent/JPS56122348A/en
Publication of JPS6228952B2 publication Critical patent/JPS6228952B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formula I (R is H or OH-protecting group) or its OH-protected derivative.
EXAMPLE: 25-Hydroxy-26,26,26-trifluorovitamin D3.
USE: Drug having bone resorption activity or calcium absorption activity through the intestinal canals of mammals, similar to known vitamin D3 compounds.
PROCESS: The compound of formula III or its OH-protected derivative can be prepared by irradiating UV-light (200W360nm, pref. 260W310nm) to the compound of formula II or its OH-protected derivative pref. in an inert organic solvent at -20W +120°C. Isomerization of the compound of formula III with thermal energy, followed by optional removal of the OH-protecting group, gives the compound of formula I or its OH-protected derivative.
COPYRIGHT: (C)1981,JPO&Japio
JP2519580A 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation Granted JPS56122348A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2519580A JPS56122348A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2519580A JPS56122348A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation

Publications (2)

Publication Number Publication Date
JPS56122348A true JPS56122348A (en) 1981-09-25
JPS6228952B2 JPS6228952B2 (en) 1987-06-23

Family

ID=12159173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2519580A Granted JPS56122348A (en) 1980-03-03 1980-03-03 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation

Country Status (1)

Country Link
JP (1) JPS56122348A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579212B2 (en) * 1984-12-19 1988-11-17 F. Hoffmann-La Roche Ag Cholecalciferol derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579212B2 (en) * 1984-12-19 1988-11-17 F. Hoffmann-La Roche Ag Cholecalciferol derivatives

Also Published As

Publication number Publication date
JPS6228952B2 (en) 1987-06-23

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