JPS54154735A - Production of 4-hydroxy-2-cycloalkenone - Google Patents
Production of 4-hydroxy-2-cycloalkenoneInfo
- Publication number
- JPS54154735A JPS54154735A JP6090078A JP6090078A JPS54154735A JP S54154735 A JPS54154735 A JP S54154735A JP 6090078 A JP6090078 A JP 6090078A JP 6090078 A JP6090078 A JP 6090078A JP S54154735 A JPS54154735 A JP S54154735A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alumina
- hydroxy
- epoxycycloalkanone
- epoxycyclopentanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: 3,4-Epoxycycloalkanone is treated with alumina and isomerized to title compound useful as intermediates for drugs, as prostaglandin and maytansine, having carcinostatic activity, or agricultural chemicals, in one step in high yield.
CONSTITUTION: The isomerization of 3,4-epoxycycloalkanone of formula I (Z is 1W4C ring-forming alkylene, wherein at least one of carbon atoms forming 5W8 membered ring may be substituted with a monofunctional 1W10C organic radical), as 3,4-epoxycyclopentanone, is effected by treating it with an alumina, preferably basic alumina to produce the objective compound of formula II, as 4-hydroxy-3-cyclopentenone. The compound of formula I is preferably an unsubstituted 3-cyclo-alkenone of formula III(Z' is Z), especially 3,4-epoxycyclopentanone of formula IV (R is organic radical).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6090078A JPS54154735A (en) | 1978-05-24 | 1978-05-24 | Production of 4-hydroxy-2-cycloalkenone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6090078A JPS54154735A (en) | 1978-05-24 | 1978-05-24 | Production of 4-hydroxy-2-cycloalkenone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54154735A true JPS54154735A (en) | 1979-12-06 |
JPS6143336B2 JPS6143336B2 (en) | 1986-09-26 |
Family
ID=13155683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6090078A Granted JPS54154735A (en) | 1978-05-24 | 1978-05-24 | Production of 4-hydroxy-2-cycloalkenone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54154735A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5677237A (en) * | 1979-11-28 | 1981-06-25 | T Hasegawa Co Ltd | 2-substituted-hydroxycyclopentenone and its preparation |
-
1978
- 1978-05-24 JP JP6090078A patent/JPS54154735A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5677237A (en) * | 1979-11-28 | 1981-06-25 | T Hasegawa Co Ltd | 2-substituted-hydroxycyclopentenone and its preparation |
JPS6248656B2 (en) * | 1979-11-28 | 1987-10-15 | Hasegawa T Co Ltd |
Also Published As
Publication number | Publication date |
---|---|
JPS6143336B2 (en) | 1986-09-26 |
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