KR860700354A - 1α-히드록시비타민 D 화합물의 제조방법 - Google Patents

1α-히드록시비타민 D 화합물의 제조방법

Info

Publication number
KR860700354A
KR860700354A KR1019860700401A KR860700401A KR860700354A KR 860700354 A KR860700354 A KR 860700354A KR 1019860700401 A KR1019860700401 A KR 1019860700401A KR 860700401 A KR860700401 A KR 860700401A KR 860700354 A KR860700354 A KR 860700354A
Authority
KR
South Korea
Prior art keywords
vitamin
trans
compound
hydroxy
mixture
Prior art date
Application number
KR1019860700401A
Other languages
English (en)
Other versions
KR930003496B1 (ko
Inventor
에프 데루카(외 3) 헥토어
Original Assignee
원본미기재
위스콘신 알룸니 리서어치 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 위스콘신 알룸니 리서어치 파운데이션 filed Critical 원본미기재
Publication of KR860700354A publication Critical patent/KR860700354A/ko
Application granted granted Critical
Publication of KR930003496B1 publication Critical patent/KR930003496B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

1α-히드록시비타민 D 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

1α-히드록시비타민 D 화합물과 그에 상응하는 1α-히드록시-5,6-트란스-비타민 D 이성체가 함유된 혼합물을 친디엔체로 처리함으로써, 1α-히드록시-5,6-트란스-비타민 D 이성체의 친디엔체-부가물과 미반응 1α-히드록시비타민 D 화합물이 함유된 혼합물을 얻고, 상기 혼합물을 분리시키는 것으로 구성되는 1α-히드록시비타민 D 화합물의 제조방법.
제1항에 있어서, 친디엔체가 말레인산, 말레인산, 모노알킬에스테르, 말레인산 디알킬 에스테르 및 무수말레인산으로 이루어진 군으로 부터 선택되는 방법.
제1항에 있어서, 사용된 친디엔체가 아세틸렌 디카르복실산 또는 그의 알킬-또는 디알킬 에스테르인 방법.
제1항에 있어서, 친디엔체가 4-알킬-또는 4-아릴-트리아졸린-3,5-디온 화합물인 방법.
제1항에 있어서, 원하는 1α-히드록시비타민 D화합물이 크로마토그라피에 의하여 5,6-트란스 이성체의 부가물로 부터 분리되는 방법.
제2항 또는 제3항에 있어서, 혼합물을 알칼리금속 수산화물로 처리하고 수성 및 유기용매 매체 사이에 분배시켜 1α-히드록시비타민 D 화합물이 유기용매로 부터 회수될 수 있도록 함으로써, 원하는 1α-히드록시비타민 D 화합물이 5,6-트란스-비타민 D 이성체의 부가물로 부터 분리되는 방법.
제1항에 있어서, 시스/트란스 비타민 D 혼합물속에 1α-히드록시비타민 D3와 1α-히드록시-5,6-트란스-비타민 D3가 함유되어 있는 방법.
제1항에 있어서, 시스/트란스 비타민 D 혼합물속에 1α-히드록시비타민 D2와 1α-히드록시-5,6-트란스-비타민 D2가 함유되어 있는 방법.
제1항에 있어서, 시스/트란스 비타민 D 혼합물속에 1α,25-디히드록시비타민 D3와 1α, 25-디히드록시-5,6-트란스-비타민 D3가 함유되어 있는 방법.
제1항에 있어서, 시스/트란스 비타민 D 혼합물속에 1α, 25-디히드록시비타민 D2와 1α, 25-디히드록시-5,6-트란스-비타민 D2가 함유되어 있는 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860700401A 1984-11-01 1985-10-15 1α-히드록시비타민 D화합물의 제조방법 KR930003496B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/667,295 US4554106A (en) 1984-11-01 1984-11-01 Method for preparing 1α-hydroxyvitamin D compounds
US667,295 1984-11-01
US667295 1984-11-01
PCT/US1985/001980 WO1986002648A1 (en) 1984-11-01 1985-10-15 METHOD FOR PREPARING 1alpha-HYDROXYVITAMIN D COMPOUNDS

Publications (2)

Publication Number Publication Date
KR860700354A true KR860700354A (ko) 1986-10-06
KR930003496B1 KR930003496B1 (ko) 1993-05-01

Family

ID=24677641

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860700401A KR930003496B1 (ko) 1984-11-01 1985-10-15 1α-히드록시비타민 D화합물의 제조방법

Country Status (12)

Country Link
US (1) US4554106A (ko)
EP (1) EP0198901B1 (ko)
JP (1) JPS62500718A (ko)
KR (1) KR930003496B1 (ko)
AU (1) AU596085B2 (ko)
CA (1) CA1233188A (ko)
DE (1) DE3585687D1 (ko)
DK (1) DK153836C (ko)
IE (1) IE58163B1 (ko)
IL (1) IL76753A (ko)
NZ (1) NZ213845A (ko)
WO (1) WO1986002648A1 (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555364A (en) * 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
CH669706GA3 (en) * 1987-04-01 1989-04-14 Bracelet and surround for watch - has pair of rings with channels fitting over projecting ribs around watch casing
US5602116A (en) * 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) * 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5869472A (en) * 1994-07-18 1999-02-09 Bone Care International, Inc. Synthesis of 1α-hydroxy vitamin D
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6376479B1 (en) 1995-04-03 2002-04-23 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
BR9815442A (pt) * 1997-02-13 2001-08-21 Bone Care Int Inc Liberação terapêutica dirigida de compostos de vitamina d
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
JPH1175863A (ja) * 1997-07-10 1999-03-23 Kyowa Hakko Kogyo Co Ltd ２５−ヒドロキシビタミンＤ３−１α−水酸化酵素および該酵素をコードするＤＮＡ
US6096876A (en) * 1997-08-06 2000-08-01 Shriners Hospitals For Children 1-α-hydroxylase materials and methods
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6359012B1 (en) 1999-12-22 2002-03-19 Bone Care International, Inc. Method for making 24(S)-hydroxyvitamin D2
IL153378A0 (en) * 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
WO2005102355A1 (en) * 2004-04-23 2005-11-03 Genzyme Corporation METHODS OF TREATING VARIOUS VITAMIN D METABOLISM CONDITIONS WITH 1α-HYDROXYVITAMIN D2
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US8617898B2 (en) * 2010-01-25 2013-12-31 Dh Technologies Development Pte. Ltd. Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
CN103073469A (zh) * 2013-01-16 2013-05-01 青岛正大海尔制药有限公司 一种阿法骨化醇的制备方法
CN111072540A (zh) * 2019-12-26 2020-04-28 山东华铂凯盛生物科技有限公司 一种阿法骨化醇改进的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022768A (en) * 1976-02-12 1977-05-10 Wisconsin Alumni Research Foundation Process for preparation of 1α,25-dihydroxycholecalciferol
US4202829A (en) * 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4287129A (en) * 1980-07-28 1981-09-01 Diamond Shamrock Corp. Synthesis of 1α-hydroxy-7-dehydrosteroids
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process

Also Published As

Publication number Publication date
AU5064785A (en) 1986-05-15
EP0198901B1 (en) 1992-03-18
EP0198901A1 (en) 1986-10-29
KR930003496B1 (ko) 1993-05-01
JPH0437075B2 (ko) 1992-06-18
JPS62500718A (ja) 1987-03-26
EP0198901A4 (en) 1987-03-09
DK302086D0 (da) 1986-06-26
IL76753A0 (en) 1986-02-28
CA1233188A (en) 1988-02-23
IL76753A (en) 1989-10-31
DK153836C (da) 1989-01-23
AU596085B2 (en) 1990-04-26
DK153836B (da) 1988-09-12
DK302086A (da) 1986-06-26
US4554106A (en) 1985-11-19
WO1986002648A1 (en) 1986-05-09
IE852705L (en) 1986-05-01
NZ213845A (en) 1989-08-29
DE3585687D1 (de) 1992-04-23
IE58163B1 (en) 1993-07-28

Similar Documents

Publication Publication Date Title
KR860700354A (ko) 1α-히드록시비타민 D 화합물의 제조방법
KR860700353A (ko) 1-히드록시비타민 d 화합물의 제조방법
DE69533793D1 (de) Lösungsmittel-extraktionsverfahren
ES2071706T3 (es) Metodo para fraccionar proteinas plasmaticas.
AU547549B2 (en) Preparation of hydroxy compounds by electrochemical reduction
KR890001566A (ko) 비타민 d 화합물의 제조방법
IE39855L (en) Process for the preparation of isoprene
EP0289461A3 (en) Method of purifying polydextrose and composition containing same
ES8601711A1 (es) Procedimiento para la separacion de oxo-alcoholes de cadena lineal de mezclas de oxo-alcoholes de cadena lineal y cadenaramificada
DE3687469D1 (de) Reinigung von dem wachstumshormon angehoerenden stoffen.
DE69411492D1 (de) Verfahren zur Reinigung von mittleren Olefinen
KR880005079A (ko) 3-아미노카르보닐-1,4-디히드로피리딘-5-카르복실산 화합물, 그의 제조방법, 및 그를 함유하는 약학조성물
JPS5242825A (en) Separation and purification process for isomers of benzene derivatives
EP0187479A3 (en) Extraction of aromatics with ethyl acetoacetate
EP0141271A3 (en) Tall oil fatty acids - quality improvement
KR880012226A (ko) 외 용 제
KR880007414A (ko) 이소프로필 알콜 정제방법
JPS5585532A (en) Separation of cresol
JPS51119706A (en) Solvent fractionation of fat and oil
IE33445B1 (en) Pentol derivatives,process for their manufacture and compositions containing them
ATE65799T1 (de) Verfahren zur isolierung von organischen wertprodukten aus feste biomasse enthalenden, waessrigen fermentationsloesungen.
EP0170839A3 (en) A mixture of diastereoisomer compounds, as obtained from (-)-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one, having mucose-cretolytic activity, a process for its preparation and pharmaceutical compositions containing the same
JPS51149212A (en) Process for separating mixture of benzen and alcohols
GB1149369A (en) Compounds from ravensara aromatica and process for preparing it
JPS5780341A (en) 22-carboxyl vitamin d3 and its preparation

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
J204 Request for invalidation trial [patent]
J206 Request for trial to confirm the scope of a patent right
J2X1 Appeal (before the patent court)

Free format text: CONFIRMATION OF THE SCOPE OF RIGHT

J122 Written withdrawal of action (patent court)
FPAY Annual fee payment

Payment date: 20050422

Year of fee payment: 13

EXPY Expiration of term