DK302086A - Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser - Google Patents

Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser Download PDF

Info

Publication number
DK302086A
DK302086A DK302086A DK302086A DK302086A DK 302086 A DK302086 A DK 302086A DK 302086 A DK302086 A DK 302086A DK 302086 A DK302086 A DK 302086A DK 302086 A DK302086 A DK 302086A
Authority
DK
Denmark
Prior art keywords
hydroxyvitamin
alfa
preparing
compounds
procedure
Prior art date
Application number
DK302086A
Other languages
English (en)
Other versions
DK302086D0 (da
DK153836C (da
DK153836B (da
Inventor
Hector F Deluca
Heinrich K Schnoes
Seok Ho Lee
Mary E Phelps
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK302086D0 publication Critical patent/DK302086D0/da
Publication of DK302086A publication Critical patent/DK302086A/da
Publication of DK153836B publication Critical patent/DK153836B/da
Application granted granted Critical
Publication of DK153836C publication Critical patent/DK153836C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK302086A 1984-11-01 1986-06-26 Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser ud fra en blanding af 1 alfa-hydroxy-vitamin d forbindelser og deres tilsvarende 1 alfa-hydroxy-5,6-trans-vitamin d-isomere DK153836C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66729584 1984-11-01
US06/667,295 US4554106A (en) 1984-11-01 1984-11-01 Method for preparing 1α-hydroxyvitamin D compounds
US8501980 1985-10-15
PCT/US1985/001980 WO1986002648A1 (en) 1984-11-01 1985-10-15 METHOD FOR PREPARING 1alpha-HYDROXYVITAMIN D COMPOUNDS

Publications (4)

Publication Number Publication Date
DK302086D0 DK302086D0 (da) 1986-06-26
DK302086A true DK302086A (da) 1986-06-26
DK153836B DK153836B (da) 1988-09-12
DK153836C DK153836C (da) 1989-01-23

Family

ID=24677641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK302086A DK153836C (da) 1984-11-01 1986-06-26 Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser ud fra en blanding af 1 alfa-hydroxy-vitamin d forbindelser og deres tilsvarende 1 alfa-hydroxy-5,6-trans-vitamin d-isomere

Country Status (12)

Country Link
US (1) US4554106A (da)
EP (1) EP0198901B1 (da)
JP (1) JPS62500718A (da)
KR (1) KR930003496B1 (da)
AU (1) AU596085B2 (da)
CA (1) CA1233188A (da)
DE (1) DE3585687D1 (da)
DK (1) DK153836C (da)
IE (1) IE58163B1 (da)
IL (1) IL76753A (da)
NZ (1) NZ213845A (da)
WO (1) WO1986002648A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555364A (en) * 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
CH669706GA3 (en) * 1987-04-01 1989-04-14 Bracelet and surround for watch - has pair of rings with channels fitting over projecting ribs around watch casing
US5602116A (en) * 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) * 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5869472A (en) * 1994-07-18 1999-02-09 Bone Care International, Inc. Synthesis of 1α-hydroxy vitamin D
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
US6376479B1 (en) 1995-04-03 2002-04-23 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
JP2001511811A (ja) * 1997-02-13 2001-08-14 ボーン ケア インターナショナル インコーポレイテッド ビタミンｄ化合物の標的治療放出
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
JPH1175863A (ja) 1997-07-10 1999-03-23 Kyowa Hakko Kogyo Co Ltd ２５−ヒドロキシビタミンＤ３−１α−水酸化酵素および該酵素をコードするＤＮＡ
US6096876A (en) * 1997-08-06 2000-08-01 Shriners Hospitals For Children 1-α-hydroxylase materials and methods
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6359012B1 (en) 1999-12-22 2002-03-19 Bone Care International, Inc. Method for making 24(S)-hydroxyvitamin D2
IL153378A0 (en) * 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20050239756A1 (en) * 2004-04-23 2005-10-27 Bone Care International, Inc. Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP2528443B1 (en) * 2010-01-25 2017-01-11 DH Technologies Development Pte. Ltd. Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
CN103073469A (zh) * 2013-01-16 2013-05-01 青岛正大海尔制药有限公司 一种阿法骨化醇的制备方法
CN111072540A (zh) * 2019-12-26 2020-04-28 山东华铂凯盛生物科技有限公司 一种阿法骨化醇改进的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022768A (en) * 1976-02-12 1977-05-10 Wisconsin Alumni Research Foundation Process for preparation of 1α,25-dihydroxycholecalciferol
US4202829A (en) * 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4287129A (en) * 1980-07-28 1981-09-01 Diamond Shamrock Corp. Synthesis of 1α-hydroxy-7-dehydrosteroids
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process

Also Published As

Publication number Publication date
DK302086D0 (da) 1986-06-26
AU596085B2 (en) 1990-04-26
IE58163B1 (en) 1993-07-28
EP0198901A1 (en) 1986-10-29
DE3585687D1 (de) 1992-04-23
WO1986002648A1 (en) 1986-05-09
AU5064785A (en) 1986-05-15
IL76753A0 (en) 1986-02-28
KR860700354A (ko) 1986-10-06
DK153836C (da) 1989-01-23
JPH0437075B2 (da) 1992-06-18
EP0198901B1 (en) 1992-03-18
US4554106A (en) 1985-11-19
IE852705L (en) 1986-05-01
CA1233188A (en) 1988-02-23
KR930003496B1 (ko) 1993-05-01
EP0198901A4 (en) 1987-03-09
IL76753A (en) 1989-10-31
JPS62500718A (ja) 1987-03-26
DK153836B (da) 1988-09-12
NZ213845A (en) 1989-08-29

Similar Documents

Publication Publication Date Title
DK302086D0 (da) Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser
DK162647C (da) Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner
DK301986D0 (da) Fremgangsmaade til fremstilling af 1-hydroxyvitamin-d-forbindelser
DK308085A (da) Fremgangsmaade til ekstrudering af silicaholdige materialer
DK379985D0 (da) Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin
DK160829C (da) Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner
DK156085D0 (da) Fremgangsmaade til fremstilling af acetoxyazetidinoner
DK160489C (da) Fremgangsmaade til fremstilling af 2,3-difluorpyridinforbindelser
DK294584D0 (da) Fremgangsmaade til fremstilling af formparter
ES547411A0 (es) Procedimiento de preparar compuestos triaminobencenicos yo- dados
DK153488C (da) Fremgangsmaade til fremstilling af 5,6,7,7a-tetrahydro-4h-thieno(3,2-c-)-pyridin-2-onderivater
DK245682A (da) Fremgangsmaade til fremstilling af basisk substituerede phenylacetonitril-forbindelser
DK190385D0 (da) Fremgangsmaade til fremstilling af cephalosporinforbindelser
DK294781A (da) Fremgangsmaade til fremstilling af 3-keto-5-oxy-cyclopenten-forbindelser
DK221682A (da) Fremgangsmaade til fremstilling af pyridothienopyridazinforbindelser
DK522982A (da) Fremgangsmaade til fremstilling af 8-halogenalkyl-4h-(1)-benzopyran-4-on-forbindelser
DK504988A (da) Fremgangsmaade til fremstilling af makrolidforbindelser
DK505888D0 (da) Fremgangsmaade til fremstilling af makrolidforbindelser
DK153475C (da) Fremgangsmaade til fremstilling af pyridyloxyphenolforbindelser
DK377685D0 (da) Fremgangsmaade til fremstilling af krystallinske silicophosphoaluminater
DK40284A (da) Fremgangsmaade til fremstilling af n-phosphonmethylglycin
DK521885A (da) Fremgangsmaade til fremstilling af benzopyranotriazoler
DK564985D0 (da) Fremgangsmaade til fremstilling af alkylthioacetamidiner
DK150695C (da) Fremgangsmaade til fremstilling af en broedforbedrende komposition
ES542137A0 (es) Procedimiento de preparar compuestos imidato

Legal Events

Date Code Title Description
PBP Patent lapsed