KR890001566A - 비타민 d 화합물의 제조방법 - Google Patents

비타민 d 화합물의 제조방법 Download PDF

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Publication number
KR890001566A
KR890001566A KR1019880008420A KR880008420A KR890001566A KR 890001566 A KR890001566 A KR 890001566A KR 1019880008420 A KR1019880008420 A KR 1019880008420A KR 880008420 A KR880008420 A KR 880008420A KR 890001566 A KR890001566 A KR 890001566A
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South Korea
Prior art keywords
actinomycetes
vitamin
streptomyces
compound
genus
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KR1019880008420A
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KR960004452B1 (ko
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사다후미 오무라
조지 사사끼
아끼꼬 미까미
가즈또시 미조우에
Original Assignee
우에하라 아끼라
다이쇼 세이야꾸 가부시끼가이샤
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Publication of KR890001566A publication Critical patent/KR890001566A/ko
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Publication of KR960004452B1 publication Critical patent/KR960004452B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/826—Actinomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

비타민 D 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 비타민 D 화합물을 히드록시화할 수 있는 방선균 균체 또는 이로부터 생산되는 효소를 함유하는 반응 혼합물 중에 1α 또는 25위치에 수소원자를 함유하는 비타민 D 화합물을 첨가하여, 각각의 수소원자를 히드록실기로 변환시킴을 특징으로 하는 1α-또는 25-히드록시 비타민 D 화합물의 제조방법.
  2. 비타민 D화합물을 히드록실화할 수 있는 방선균 균체 또는 이로부터 생산되는 효소를 함유하는 반응혼합물 중에 1α 및 25위치에 수소원자를 함유하는 비타민 D 화합물을 첨가하여 각각의 수소원자를 히드록실기로 변환시킴을 특징으로 하는 25-히드록시 비타민 D 화합을 또는 1α,25-디히드록시 비타민 D 화합물의 제조방법.
  3. 제1항에 있어서, 방선균이 스트렙토마이세스속 또는 노카르디아속인 방법.
  4. 제2항에 있어서, 방선균이 스트렙토마이세스속 또는 노카르디아속인 방법.
  5. 제1항에 있어서, 방선균이 스트렙토마이세스 스클레로티알루스 T-JS1인 방법.
  6. 제2항에 있어서, 방선균이 스트렙토마이세스 스클레로티알루스 T-JS1인 방법.
  7. 제1항에 있어서, 방선균이 스트렙토마이세스 로제오스포루스 A-5797인 방법.
  8. 제2항에 있어서, 방선균이 스트렙토마이세스 로제오스포루스 A-5797인 방법.
  9. 제1항에 있어서, 방선균이 노카르디아 아우토트로피카 N-102인 방법.
  10. 제2항에 있어서, 방선균이 노카르디아 아우토트로피카 N-102인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008420A 1987-07-08 1988-07-07 비타민 d 화합물의 제조 방법 KR960004452B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP62-170669 1987-07-08
JP17066987 1987-07-08
JP331323 1987-12-26
JP62-331323 1987-12-26
JP33132387 1987-12-26

Publications (2)

Publication Number Publication Date
KR890001566A true KR890001566A (ko) 1989-03-27
KR960004452B1 KR960004452B1 (ko) 1996-04-06

Family

ID=26493597

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008420A KR960004452B1 (ko) 1987-07-08 1988-07-07 비타민 d 화합물의 제조 방법

Country Status (5)

Country Link
US (1) US4892821A (ko)
EP (1) EP0298757B1 (ko)
KR (1) KR960004452B1 (ko)
DE (1) DE3884870T2 (ko)
ES (1) ES2047033T3 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法
WO1997049829A1 (fr) * 1996-06-27 1997-12-31 Mercian Corporation Procede biologique servant a preparer des steroides 25-hydroxyles
TWI247001B (en) * 1996-07-01 2006-01-11 Chugai Pharmaceutical Co Ltd The method for purifying vitamin d derivatives and its crystalline products
EP1172442A4 (en) * 1999-04-14 2004-10-13 Mercian Corp VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
DK1993559T3 (en) 2006-02-03 2016-10-03 Opko Renal Llc Treatment of vitamin D deficiency and MALFUNCTION with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
WO2007138894A1 (ja) 2006-05-31 2007-12-06 Mercian Corporation 水酸化酵素遺伝子及びその用途
ES2670029T3 (es) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D
DK2481400T3 (da) 2007-04-25 2014-09-29 Opko Ip Holdings Ii Inc Orale præparater med kontrolleret frigivelse omfattende en vitamin D-forbindelse og en voksagtig bærer
KR101495578B1 (ko) 2007-04-25 2015-02-25 사이토크로마 인코포레이티드 비타민 ｄ 부족 및 결핍의 치료 방법
ES2954932T3 (es) 2008-04-02 2023-11-27 Eirgen Pharma Ltd Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados
US8545915B2 (en) * 2008-05-02 2013-10-01 Oakshire Holdings, Inc. Method and apparatus for vitamin D enhancement in mushrooms
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
US20160205981A1 (en) 2012-09-27 2016-07-21 Oakshire Holdings, Inc. Method and apparatus for vitamin d enhancement in mushrooms
US9326540B2 (en) 2012-09-27 2016-05-03 Oakshire Holdings, Inc. Method and apparatus for vitamin D enhancement in mushrooms
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
IL290855B2 (en) 2016-03-28 2024-06-01 Eirgen Pharma Ltd Treatment methods using vitamin D

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4279826A (en) * 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process
US4502991A (en) * 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
ES2047033T3 (es) 1994-02-16
EP0298757B1 (en) 1993-10-13
DE3884870T2 (de) 1994-02-03
US4892821A (en) 1990-01-09
DE3884870D1 (de) 1993-11-18
KR960004452B1 (ko) 1996-04-06
EP0298757A1 (en) 1989-01-11

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