KR860004073A - 콜레칼시페롤 유도체의 제조방법 - Google Patents

콜레칼시페롤 유도체의 제조방법 Download PDF

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Publication number
KR860004073A
KR860004073A KR1019850008546A KR850008546A KR860004073A KR 860004073 A KR860004073 A KR 860004073A KR 1019850008546 A KR1019850008546 A KR 1019850008546A KR 850008546 A KR850008546 A KR 850008546A KR 860004073 A KR860004073 A KR 860004073A
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KR
South Korea
Prior art keywords
methyl
preparing
trimethylsilyloxy
inden
octahydro
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KR1019850008546A
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English (en)
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KR930007993B1 (ko
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바기올리니 엔리코 (외 3)
Original Assignee
얀 야퀘스오게이 노버트 아. 코통
에프. 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
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Application filed by 얀 야퀘스오게이 노버트 아. 코통, 에프. 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트 filed Critical 얀 야퀘스오게이 노버트 아. 코통
Publication of KR860004073A publication Critical patent/KR860004073A/ko
Application granted granted Critical
Publication of KR930007993B1 publication Critical patent/KR930007993B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/44—Halogenated unsaturated alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

콜레칼시페를 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. [1R-1β(R*), 3aα,4β,7aβ]]-옥타히드로-1-[6,6,6-트리플루오로-5-트리메틸실릴옥시]-5-트리플루오로메틸-1-메틸-2-헥센일]-7a-메틸-1H-인덴-4-온 또는 [1R-[1β(R*)3aα,4β7aβ]-옥타히드로-1-[6,6,6-트리플루오로-5-트리메틸실릴옥시-5-트리플루오로메틸-1-메틸-3-헥센일]-7a-메틸-1H-인덴-4-온을 각각 [3 S-[3S-(3a,5β,Z)]-2-[2-메틸렌-3,5-비스[(1,1-디-메틸에틸)디메틸실릴옥시]시클로헥실리덴]에틸디페닐 포스핀 옥사이드와 반응시키고, 실릴보호기를 제거시킴을 특징으로하는 Δ22- 또는 Δ23-26,26,26,27,27,27-헥사플루오로-1α-25-디히드록시콜레칼시페롤의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850008546A 1984-11-16 1985-11-15 콜레칼시페롤 유도체의 제조방법 KR930007993B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US672,059 1984-11-16
US06/672,059 US4613594A (en) 1984-11-16 1984-11-16 Fluorinated vitamin D3 compounds

Publications (2)

Publication Number Publication Date
KR860004073A true KR860004073A (ko) 1986-06-16
KR930007993B1 KR930007993B1 (ko) 1993-08-25

Family

ID=24696990

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008546A KR930007993B1 (ko) 1984-11-16 1985-11-15 콜레칼시페롤 유도체의 제조방법

Country Status (21)

Country Link
US (1) US4613594A (ko)
EP (1) EP0182298B1 (ko)
JP (1) JPS61122237A (ko)
KR (1) KR930007993B1 (ko)
AR (1) AR242767A1 (ko)
AT (1) ATE48412T1 (ko)
AU (1) AU588012B2 (ko)
CA (1) CA1286693C (ko)
DE (1) DE3574587D1 (ko)
DK (1) DK159652C (ko)
ES (1) ES8801198A1 (ko)
FI (1) FI84599C (ko)
HU (1) HU194162B (ko)
IE (1) IE58851B1 (ko)
IL (1) IL77052A (ko)
MC (1) MC1709A1 (ko)
NO (1) NO162906C (ko)
NZ (1) NZ214175A (ko)
PH (1) PH21540A (ko)
PT (1) PT81502B (ko)
ZA (1) ZA858151B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63196556A (ja) * 1987-02-10 1988-08-15 Taisho Pharmaceut Co Ltd 含フツ素ビタミンｄ誘導体
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5278155A (en) * 1991-06-05 1994-01-11 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
EP0521550B1 (en) * 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
JPS57149224A (en) * 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
DE3471928D1 (en) * 1983-01-28 1988-07-14 Hoffmann La Roche Process for the preparation of cholecalciferol derivatives
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters

Also Published As

Publication number Publication date
FI854492A (fi) 1986-05-17
ZA858151B (en) 1986-06-25
DK159652C (da) 1991-04-08
CA1286693C (en) 1991-07-23
DK524585D0 (da) 1985-11-13
ES548910A0 (es) 1987-12-16
IL77052A (en) 1990-02-09
FI854492A0 (fi) 1985-11-14
NO162906C (no) 1990-03-07
DE3574587D1 (de) 1990-01-11
DK159652B (da) 1990-11-12
PT81502B (pt) 1988-03-03
PH21540A (en) 1987-11-16
PT81502A (en) 1985-12-01
NO854576L (no) 1986-05-20
AR242767A1 (es) 1993-05-31
US4613594A (en) 1986-09-23
EP0182298B1 (de) 1989-12-06
HUT39138A (en) 1986-08-28
JPH051770B2 (ko) 1993-01-11
FI84599C (fi) 1991-12-27
NZ214175A (en) 1989-04-26
EP0182298A1 (de) 1986-05-28
IL77052A0 (en) 1986-04-29
DK524585A (da) 1986-05-17
IE58851B1 (en) 1993-11-17
FI84599B (fi) 1991-09-13
ES8801198A1 (es) 1987-12-16
IE852875L (en) 1986-05-16
ATE48412T1 (de) 1989-12-15
KR930007993B1 (ko) 1993-08-25
AU5089885A (en) 1986-05-29
HU194162B (en) 1988-01-28
MC1709A1 (fr) 1986-09-22
JPS61122237A (ja) 1986-06-10
AU588012B2 (en) 1989-09-07
NO162906B (no) 1989-11-27

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