KR860001809A - 3-아크릴 아미노메틸이미다조[1,2-a]피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물 - Google Patents

3-아크릴 아미노메틸이미다조[1,2-a]피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물 Download PDF

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KR860001809A
KR860001809A KR1019850005660A KR850005660A KR860001809A KR 860001809 A KR860001809 A KR 860001809A KR 1019850005660 A KR1019850005660 A KR 1019850005660A KR 850005660 A KR850005660 A KR 850005660A KR 860001809 A KR860001809 A KR 860001809A
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South Korea
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formula
hydrogen
alkyl
compound
amide
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KR1019850005660A
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KR910004450B1 (ko
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제오르즈(외 1) 파스칼
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에 뚜레-레메뜨르
신 떼라보
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

3-아크릴 아미노메틸이미다조〔1,2-a〕피리딘 유도체, 그의 제법 및 그를 포함하는 의약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. (a)일반식(Ⅱ)
    의 화합물을 포르밀화시켜 일반식(Ⅲ)
    의 알데히드를 얻고, (b)상기 알데히드(Ⅲ)를 일반식(Ⅳ)
    의 알코올로 환원시키며, (c) 상기 알코올(Ⅳ)을 일반식 R2-CN의 니트릴과 반응시켜서 R1이 수소인 일반식(Ⅰ)
    의 아미드를 얻고, 원한다면, 상기 아미드를 알킬화 또는 벤질화시켜서 R1이 C1-C4알킬 또는 벤질인 일반식(Ⅰ)의 아미드를 제공하며, 결과된 일반식(Ⅰ)의 아미드를 공지의 방법 자체로서 선택적으로 산 부가염으로 변환시키는 것으로 이루어지는 것을 특징으로 하는 일반식(Ⅰ)의 아미다조 1,2-a 피리딘 유도체 및 그의 제약성 허용되는 산염의 제조방법.
    상기 일반식(Ⅰ)에서, X는 수소, 할로겐, C1-C4알킬, 메톡시, 메틸티오, 에틸술포닐,니트로, 아미노, 메틸아미노. 디메틸아미노, 아세틸아미노 또는 디아세틸아미노이며. Y는 수소, 염소 또는메틸이고 R1은 수소, C1-C4알킬 또는 벤질이며, R2는 C1-C6알킬, 시클로헥실, 트리클로로메틸, 1-프로페닐, 알릴, 페닐, 4-클로로페닐 또는 벤질이고 R1과 R2는 함께 이가 C3-C5지방족기를 나타낸다.
  2. 제1항에 있어서, 일반식(Ⅱ)
    의 화합물을 일반식
    (여기서 R1과 R2는 제1항에 정의한 바와 같다)의 아미드와 반응시켜, 결과된 일반식(Ⅰ)의 아미드를 공지의 방법 자체로서 선택적으로 산부가염으로 변환시키는 것으로 이루어지는 것을 특징으로 하는 화합물(Ⅰ)의 제조방법.
  3. 제1항에 있어서, 일반식(Ⅱ)
    의 화합물을 파라포름알데히드와 R2-CN의 니트릴과 반응시켜(여기서R2는 제1항에 정의한 바와 같다) R1이 수소인 일반식(Ⅰ)의 아미드를 얻고, 원한다면, 상기 아미드를 알킬화 또는 벤질화시켜 R1이 C1-C4알킬 또는 벤질인 일반식(Ⅰ)의 아미드를 제공하고 결과된 일반식(Ⅰ)의 아미드를 공지의 방법 자체로서, 선택적으로 산부가염으로 변환시키는 것으로 이루어지는 것을 특징으로 하는 화합물(Ⅰ)의 제조방법.
  4. 제1항, 제2항 또는 제3항에 있어서, X는 염소 또는 메틸이고 Y는 염소, 메틸 또는 메틸티오이며, R1은 수소 또는 메틸이고 R2는 프로필 또는 이소부틸일 것을 특징으로 하는 화합물(Ⅰ)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005660A 1984-08-07 1985-08-06 3-아크릴아미노메틸이미다조[1,2-a]피리딘 유도체, 그의 제법 및 그를 포함하는 의약조성물 KR910004450B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8412447A FR2568880B1 (fr) 1984-08-07 1984-08-07 Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR84/12447 1984-08-07
FR12447 1984-08-07

Publications (2)

Publication Number Publication Date
KR860001809A true KR860001809A (ko) 1986-03-22
KR910004450B1 KR910004450B1 (ko) 1991-06-29

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US (1) US4650796A (ko)
EP (1) EP0172096B1 (ko)
JP (1) JPS6147485A (ko)
KR (1) KR910004450B1 (ko)
AR (1) AR241185A1 (ko)
AT (1) ATE40365T1 (ko)
AU (1) AU575190B2 (ko)
CA (1) CA1261830A (ko)
CZ (1) CZ357691A3 (ko)
DE (1) DE3567867D1 (ko)
DK (1) DK163923C (ko)
ES (1) ES8604592A1 (ko)
FI (1) FI80696C (ko)
FR (1) FR2568880B1 (ko)
GR (1) GR851928B (ko)
HU (1) HU193799B (ko)
IE (1) IE58347B1 (ko)
IL (1) IL76020A (ko)
MX (1) MX160845A (ko)
NO (1) NO162189C (ko)
NZ (1) NZ213013A (ko)
PT (1) PT80921B (ko)
ZA (1) ZA855939B (ko)

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FR2593818B1 (fr) * 1986-02-05 1988-04-29 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
EP0234970B1 (fr) * 1986-01-22 1991-04-17 Synthelabo Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
FR2593180B1 (fr) * 1986-01-22 1990-10-26 Synthelabo Derives d'acylaminomethyl-1 imidazo (1,2-a)quinoleines, leur preparation et leur application en therapeutique
US4990506A (en) * 1986-02-05 1991-02-05 Synthelabo 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
EP0289371B1 (fr) * 1987-03-27 1991-09-25 Synthelabo Dérivés d'imidazopyridines, leur préparation et leur application en thérapeutique
FR2615513B1 (fr) * 1987-05-21 1989-07-13 Synthelabo Derives d'acylaminomethyl-3 tetrahydro-5,6,7,8 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2654933B1 (fr) * 1989-11-30 1994-06-10 Synthelabo Utilisation d'une imidazopyridine pour la fabrication de medicaments anesthesiques.
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
DE10019714A1 (de) * 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
AU2001270297A1 (en) * 2000-06-30 2002-01-14 Neurogen Corporation 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
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JP2008542322A (ja) * 2005-06-01 2008-11-27 ユセベ ファルマ ソシエテ アノニム ２−オキソ−１−ピロリジン誘導体
WO2008132139A2 (en) * 2007-04-27 2008-11-06 Ucb Pharma S.A. New heterocyclic derivatives useful for the treatment of cns disorders
EP2300470A2 (en) * 2008-05-19 2011-03-30 Sepracor Inc. Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators
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JP2016527184A (ja) 2013-05-24 2016-09-08 イオメット ファーマ リミテッド Ｓｌｃ２ａ輸送体阻害剤
JP2023512038A (ja) * 2020-01-29 2023-03-23 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用

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Also Published As

Publication number Publication date
IE851937L (en) 1986-02-07
GR851928B (ko) 1985-12-09
DK356885D0 (da) 1985-08-06
AU575190B2 (en) 1988-07-21
ATE40365T1 (de) 1989-02-15
FI80696C (fi) 1990-07-10
IL76020A0 (en) 1985-12-31
AR241185A1 (es) 1992-01-31
HU193799B (en) 1987-11-30
US4650796A (en) 1987-03-17
NO162189C (no) 1989-11-29
CA1261830A (en) 1989-09-26
CZ357691A3 (en) 1993-06-16
FI853026A0 (fi) 1985-08-06
FI853026L (fi) 1986-02-08
EP0172096A1 (fr) 1986-02-19
DK356885A (da) 1986-02-08
FR2568880A1 (fr) 1986-02-14
AU4580985A (en) 1986-02-13
NO853100L (no) 1986-02-10
KR910004450B1 (ko) 1991-06-29
DK163923C (da) 1992-09-14
JPH0523267B2 (ko) 1993-04-02
ES8604592A1 (es) 1986-02-01
FR2568880B1 (fr) 1986-12-12
IE58347B1 (en) 1993-09-08
NZ213013A (en) 1988-05-30
DK163923B (da) 1992-04-21
MX160845A (es) 1990-05-31
ES545928A0 (es) 1986-02-01
NO162189B (no) 1989-08-14
HUT38637A (en) 1986-06-30
DE3567867D1 (en) 1989-03-02
EP0172096B1 (fr) 1989-01-25
ZA855939B (en) 1986-03-26
PT80921A (fr) 1985-09-01
IL76020A (en) 1989-01-31
FI80696B (fi) 1990-03-30
JPS6147485A (ja) 1986-03-07
PT80921B (pt) 1987-12-30

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