ES8604592A1 - Un procedimiento para preparar derivados de acilaminometil- 3-imidazo(1,2-a)piridinas - Google Patents

Un procedimiento para preparar derivados de acilaminometil- 3-imidazo(1,2-a)piridinas

Info

Publication number
ES8604592A1
ES8604592A1 ES545928A ES545928A ES8604592A1 ES 8604592 A1 ES8604592 A1 ES 8604592A1 ES 545928 A ES545928 A ES 545928A ES 545928 A ES545928 A ES 545928A ES 8604592 A1 ES8604592 A1 ES 8604592A1
Authority
ES
Spain
Prior art keywords
alkyl
acylaminomethylimidazo
pyridines
preparation
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545928A
Other languages
English (en)
Other versions
ES545928A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES8604592A1 publication Critical patent/ES8604592A1/es
Publication of ES545928A0 publication Critical patent/ES545928A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ACILAMINOMETIL-3-IMIDAZO1,2-APIRIDINAS, DE FORMULA GENERAL (I), EN LA QUE X REPRESENTA HIDROGENO, UN HALOGENO O UN GRUPO ALQUILO; Y REPRESENTA HIDROGENO, CLORO O UN GRUPO METILO; R1 REPRESENTA HIDROGENO O UN GRUPO ALQUILO; Y R2 REPRESENTA UN GRUPO ALQUILO LINEAL O RAMIFICADO, UN GRUPO CICLOHEXILO O TRICLOROMETILO, Y SUS SALES DE ADICION CON ACIDOS ACEPTABLES EN FARMACOLOGIA. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE EFECTUA UNA FORMILACION DE UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE X E Y TIENEN LOS SIGNIFICADOS YA MENCIONADOS, PARA OBTENER UN ALDEHIDO DE FORMULA GENERAL (III); SEGUNDA, DICHO ALDEHIDO DE FORMULA (III) SE REDUCE PARA FORMAR UN ALCOHOL; Y POR ULTIMO, DICHO ALCOHOL SE TRATA CON UN NITRILO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN TERAPEUTICA.
ES545928A 1984-08-07 1985-08-06 Un procedimiento para preparar derivados de acilaminometil- 3-imidazo(1,2-a)piridinas Expired ES8604592A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8412447A FR2568880B1 (fr) 1984-08-07 1984-08-07 Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES8604592A1 true ES8604592A1 (es) 1986-02-01
ES545928A0 ES545928A0 (es) 1986-02-01

Family

ID=9306856

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545928A Expired ES8604592A1 (es) 1984-08-07 1985-08-06 Un procedimiento para preparar derivados de acilaminometil- 3-imidazo(1,2-a)piridinas

Country Status (23)

Country Link
US (1) US4650796A (es)
EP (1) EP0172096B1 (es)
JP (1) JPS6147485A (es)
KR (1) KR910004450B1 (es)
AR (1) AR241185A1 (es)
AT (1) ATE40365T1 (es)
AU (1) AU575190B2 (es)
CA (1) CA1261830A (es)
CZ (1) CZ357691A3 (es)
DE (1) DE3567867D1 (es)
DK (1) DK163923C (es)
ES (1) ES8604592A1 (es)
FI (1) FI80696C (es)
FR (1) FR2568880B1 (es)
GR (1) GR851928B (es)
HU (1) HU193799B (es)
IE (1) IE58347B1 (es)
IL (1) IL76020A (es)
MX (1) MX160845A (es)
NO (1) NO162189C (es)
NZ (1) NZ213013A (es)
PT (1) PT80921B (es)
ZA (1) ZA855939B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593818B1 (fr) * 1986-02-05 1988-04-29 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
EP0234970B1 (fr) * 1986-01-22 1991-04-17 Synthelabo Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
FR2593180B1 (fr) * 1986-01-22 1990-10-26 Synthelabo Derives d'acylaminomethyl-1 imidazo (1,2-a)quinoleines, leur preparation et leur application en therapeutique
US4990506A (en) * 1986-02-05 1991-02-05 Synthelabo 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
EP0289371B1 (fr) * 1987-03-27 1991-09-25 Synthelabo Dérivés d'imidazopyridines, leur préparation et leur application en thérapeutique
FR2615513B1 (fr) * 1987-05-21 1989-07-13 Synthelabo Derives d'acylaminomethyl-3 tetrahydro-5,6,7,8 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2654933B1 (fr) * 1989-11-30 1994-06-10 Synthelabo Utilisation d'une imidazopyridine pour la fabrication de medicaments anesthesiques.
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
DE10019714A1 (de) * 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
AU2001270297A1 (en) * 2000-06-30 2002-01-14 Neurogen Corporation 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE10247269A1 (de) * 2002-10-10 2004-04-22 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine
WO2005044818A2 (en) * 2003-10-28 2005-05-19 Sepracor, Inc. Imidazo[1,2-a]pyridine anxiolytics
WO2005081749A2 (en) * 2004-01-23 2005-09-09 Avanir Pharmaceuticals, Inc. Neutralizing human antibodies to anthraxtoxin
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL1814880T3 (pl) * 2004-11-11 2009-07-31 Ferrer Int Związki imidazo[1,2-a]pirydynowe oraz kompozycje, zastosowanie i sposoby z nimi związane
JP2008542322A (ja) * 2005-06-01 2008-11-27 ユセベ ファルマ ソシエテ アノニム ２−オキソ−１−ピロリジン誘導体
WO2008132139A2 (en) * 2007-04-27 2008-11-06 Ucb Pharma S.A. New heterocyclic derivatives useful for the treatment of cns disorders
EP2300470A2 (en) * 2008-05-19 2011-03-30 Sepracor Inc. Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators
WO2010064020A1 (en) * 2008-12-04 2010-06-10 Proximagen Ltd. Imidazopyridine compounds
JP2016527184A (ja) 2013-05-24 2016-09-08 イオメット ファーマ リミテッド Ｓｌｃ２ａ輸送体阻害剤
JP2023512038A (ja) * 2020-01-29 2023-03-23 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB991589A (en) * 1963-04-30 1965-05-12 Selvi & C Lab Bioterapico Novel [1,2-ª‡]imidazopyridines and a process for the manufacture thereof
GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof

Also Published As

Publication number Publication date
IE851937L (en) 1986-02-07
GR851928B (es) 1985-12-09
KR860001809A (ko) 1986-03-22
DK356885D0 (da) 1985-08-06
AU575190B2 (en) 1988-07-21
ATE40365T1 (de) 1989-02-15
FI80696C (fi) 1990-07-10
IL76020A0 (en) 1985-12-31
AR241185A1 (es) 1992-01-31
HU193799B (en) 1987-11-30
US4650796A (en) 1987-03-17
NO162189C (no) 1989-11-29
CA1261830A (en) 1989-09-26
CZ357691A3 (en) 1993-06-16
FI853026A0 (fi) 1985-08-06
FI853026L (fi) 1986-02-08
EP0172096A1 (fr) 1986-02-19
DK356885A (da) 1986-02-08
FR2568880A1 (fr) 1986-02-14
AU4580985A (en) 1986-02-13
NO853100L (no) 1986-02-10
KR910004450B1 (ko) 1991-06-29
DK163923C (da) 1992-09-14
JPH0523267B2 (es) 1993-04-02
FR2568880B1 (fr) 1986-12-12
IE58347B1 (en) 1993-09-08
NZ213013A (en) 1988-05-30
DK163923B (da) 1992-04-21
MX160845A (es) 1990-05-31
ES545928A0 (es) 1986-02-01
NO162189B (no) 1989-08-14
HUT38637A (en) 1986-06-30
DE3567867D1 (en) 1989-03-02
EP0172096B1 (fr) 1989-01-25
ZA855939B (en) 1986-03-26
PT80921A (fr) 1985-09-01
IL76020A (en) 1989-01-31
FI80696B (fi) 1990-03-30
JPS6147485A (ja) 1986-03-07
PT80921B (pt) 1987-12-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041127