ES8603416A1 - Un procedimiento para preparar derivados de dihidropiridina - Google Patents
Un procedimiento para preparar derivados de dihidropiridinaInfo
- Publication number
- ES8603416A1 ES8603416A1 ES542186A ES542186A ES8603416A1 ES 8603416 A1 ES8603416 A1 ES 8603416A1 ES 542186 A ES542186 A ES 542186A ES 542186 A ES542186 A ES 542186A ES 8603416 A1 ES8603416 A1 ES 8603416A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- intermediates
- compounds
- therapeutically active
- yes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIHIDROPIRIDINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA H2NNH-X EN DONDE X ES H O -CONH2, EN UNA PRIMERA OPERACION, Y CON UN ALCALI, EN UNA SEGUNDA OPERACION, PARA OBTENER DERIVADOS DE DIHIDROPIRIDINA DE FORMULA (I) DONDE R1 SIGNIFICA UNO O DOS SUSTITUYENTES, IGUALES O DIFERENTES, EN EL ANILLO FENILICO, SELECCIONADOS DEL GRUPO QUE CONSISTE EN NO2, CL Y ALCOHILO INFERIOR. LA REACCION SE LLEVA A CABO EN UN MEDIO DISOLVENTE DE ELEVADO PUNTO DE EBULLICION COMO ETILENGLICOLES, ALCOHOL OCTILICO, ALCOHOL BENCILICO O TRIETANOLAMINA, Y A UNA TEMPERATURA COMPRENDIDAENTRE 180 Y 200JC. TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8203177 | 1982-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES542186A0 ES542186A0 (es) | 1985-12-16 |
ES8603416A1 true ES8603416A1 (es) | 1985-12-16 |
Family
ID=20346868
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522573A Granted ES522573A0 (es) | 1982-05-21 | 1983-05-20 | Un procedimiento para la preparacion de dihidropiridinas. |
ES542185A Expired ES8603415A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542186A Expired ES8603416A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542187A Expired ES8603417A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522573A Granted ES522573A0 (es) | 1982-05-21 | 1983-05-20 | Un procedimiento para la preparacion de dihidropiridinas. |
ES542185A Expired ES8603415A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542187A Expired ES8603417A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0095450A3 (es) |
JP (1) | JPS58210064A (es) |
KR (1) | KR900006116B1 (es) |
AU (1) | AU1464483A (es) |
CA (1) | CA1242201A (es) |
DD (2) | DD216454A5 (es) |
DK (1) | DK223783A (es) |
ES (4) | ES522573A0 (es) |
FI (1) | FI79300C (es) |
GB (1) | GB2120251B (es) |
GR (1) | GR78849B (es) |
HU (2) | HU188343B (es) |
IL (1) | IL68604A0 (es) |
IS (1) | IS1380B6 (es) |
MW (1) | MW2083A1 (es) |
NO (1) | NO162515C (es) |
NZ (1) | NZ204284A (es) |
PT (1) | PT76734B (es) |
ZA (1) | ZA833264B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
HU199796B (en) * | 1985-08-06 | 1990-03-28 | Boehringer Biochemia Srl | Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds |
IT1197012B (it) * | 1986-07-29 | 1988-11-25 | Boehringer Biochemia Srl | 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
IT1213440B (it) * | 1986-12-24 | 1989-12-20 | Boehringer Biochemia Srl | 2-ditioalchil-diidropiridine, un metodo per la loro preparazione e composizioni farmaceutiche chele contengono. |
IT1204948B (it) * | 1987-03-13 | 1989-03-10 | Boheringer Biochemia Robin S P | 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono. |
DE3741540A1 (de) * | 1987-12-08 | 1989-06-22 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen dihydropyridinen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
DE2740080A1 (de) * | 1977-09-06 | 1979-03-15 | Bayer Ag | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
GB2050375B (en) * | 1979-05-11 | 1983-02-23 | Fujisawa Pharmaceutical Co | 4-cyanophenyl-1,4-dihydropyridine compound processes for preparation thereof and pharmaceutical composition comprising the same |
SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
-
1983
- 1983-05-05 IL IL68604A patent/IL68604A0/xx unknown
- 1983-05-06 ZA ZA833264A patent/ZA833264B/xx unknown
- 1983-05-10 CA CA000427859A patent/CA1242201A/en not_active Expired
- 1983-05-13 EP EP83850126A patent/EP0095450A3/en not_active Withdrawn
- 1983-05-18 NZ NZ204284A patent/NZ204284A/en unknown
- 1983-05-18 AU AU14644/83A patent/AU1464483A/en not_active Abandoned
- 1983-05-18 MW MW20/83A patent/MW2083A1/xx unknown
- 1983-05-19 DK DK223783A patent/DK223783A/da not_active Application Discontinuation
- 1983-05-19 FI FI831779A patent/FI79300C/fi not_active IP Right Cessation
- 1983-05-19 GR GR71399A patent/GR78849B/el unknown
- 1983-05-20 HU HU831793A patent/HU188343B/hu not_active IP Right Cessation
- 1983-05-20 GB GB08314021A patent/GB2120251B/en not_active Expired
- 1983-05-20 HU HU852490A patent/HU193785B/hu unknown
- 1983-05-20 NO NO831807A patent/NO162515C/no unknown
- 1983-05-20 PT PT76734A patent/PT76734B/pt not_active IP Right Cessation
- 1983-05-20 IS IS2808A patent/IS1380B6/is unknown
- 1983-05-20 JP JP58087769A patent/JPS58210064A/ja active Pending
- 1983-05-20 DD DD83264593A patent/DD216454A5/de not_active IP Right Cessation
- 1983-05-20 DD DD83251136A patent/DD211554A5/de not_active IP Right Cessation
- 1983-05-20 ES ES522573A patent/ES522573A0/es active Granted
- 1983-05-21 KR KR1019830002236A patent/KR900006116B1/ko not_active IP Right Cessation
-
1985
- 1985-04-12 ES ES542185A patent/ES8603415A1/es not_active Expired
- 1985-04-12 ES ES542186A patent/ES8603416A1/es not_active Expired
- 1985-04-12 ES ES542187A patent/ES8603417A1/es not_active Expired
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