ES8603416A1 - Un procedimiento para preparar derivados de dihidropiridina - Google Patents

Un procedimiento para preparar derivados de dihidropiridina

Info

Publication number
ES8603416A1
ES8603416A1 ES542186A ES542186A ES8603416A1 ES 8603416 A1 ES8603416 A1 ES 8603416A1 ES 542186 A ES542186 A ES 542186A ES 542186 A ES542186 A ES 542186A ES 8603416 A1 ES8603416 A1 ES 8603416A1
Authority
ES
Spain
Prior art keywords
processes
intermediates
compounds
therapeutically active
yes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542186A
Other languages
English (en)
Other versions
ES542186A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of ES542186A0 publication Critical patent/ES542186A0/es
Publication of ES8603416A1 publication Critical patent/ES8603416A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIHIDROPIRIDINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA H2NNH-X EN DONDE X ES H O -CONH2, EN UNA PRIMERA OPERACION, Y CON UN ALCALI, EN UNA SEGUNDA OPERACION, PARA OBTENER DERIVADOS DE DIHIDROPIRIDINA DE FORMULA (I) DONDE R1 SIGNIFICA UNO O DOS SUSTITUYENTES, IGUALES O DIFERENTES, EN EL ANILLO FENILICO, SELECCIONADOS DEL GRUPO QUE CONSISTE EN NO2, CL Y ALCOHILO INFERIOR. LA REACCION SE LLEVA A CABO EN UN MEDIO DISOLVENTE DE ELEVADO PUNTO DE EBULLICION COMO ETILENGLICOLES, ALCOHOL OCTILICO, ALCOHOL BENCILICO O TRIETANOLAMINA, Y A UNA TEMPERATURA COMPRENDIDAENTRE 180 Y 200JC. TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES542186A 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina Expired ES8603416A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8203177 1982-05-21

Publications (2)

Publication Number Publication Date
ES542186A0 ES542186A0 (es) 1985-12-16
ES8603416A1 true ES8603416A1 (es) 1985-12-16

Family

ID=20346868

Family Applications (4)

Application Number Title Priority Date Filing Date
ES522573A Granted ES522573A0 (es) 1982-05-21 1983-05-20 Un procedimiento para la preparacion de dihidropiridinas.
ES542185A Expired ES8603415A1 (es) 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina
ES542186A Expired ES8603416A1 (es) 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina
ES542187A Expired ES8603417A1 (es) 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES522573A Granted ES522573A0 (es) 1982-05-21 1983-05-20 Un procedimiento para la preparacion de dihidropiridinas.
ES542185A Expired ES8603415A1 (es) 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES542187A Expired ES8603417A1 (es) 1982-05-21 1985-04-12 Un procedimiento para preparar derivados de dihidropiridina

Country Status (19)

Country Link
EP (1) EP0095450A3 (es)
JP (1) JPS58210064A (es)
KR (1) KR900006116B1 (es)
AU (1) AU1464483A (es)
CA (1) CA1242201A (es)
DD (2) DD216454A5 (es)
DK (1) DK223783A (es)
ES (4) ES522573A0 (es)
FI (1) FI79300C (es)
GB (1) GB2120251B (es)
GR (1) GR78849B (es)
HU (2) HU188343B (es)
IL (1) IL68604A0 (es)
IS (1) IS1380B6 (es)
MW (1) MW2083A1 (es)
NO (1) NO162515C (es)
NZ (1) NZ204284A (es)
PT (1) PT76734B (es)
ZA (1) ZA833264B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204421B (it) * 1986-06-27 1989-03-01 Boehringer Biochemia Srl 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
HU199796B (en) * 1985-08-06 1990-03-28 Boehringer Biochemia Srl Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
IT1197012B (it) * 1986-07-29 1988-11-25 Boehringer Biochemia Srl 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
IT1213440B (it) * 1986-12-24 1989-12-20 Boehringer Biochemia Srl 2-ditioalchil-diidropiridine, un metodo per la loro preparazione e composizioni farmaceutiche chele contengono.
IT1204948B (it) * 1987-03-13 1989-03-10 Boheringer Biochemia Robin S P 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono.
DE3741540A1 (de) * 1987-12-08 1989-06-22 Bayer Ag Verfahren zur herstellung von unsymmetrischen dihydropyridinen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2740080A1 (de) * 1977-09-06 1979-03-15 Bayer Ag 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
GB2050375B (en) * 1979-05-11 1983-02-23 Fujisawa Pharmaceutical Co 4-cyanophenyl-1,4-dihydropyridine compound processes for preparation thereof and pharmaceutical composition comprising the same
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma

Also Published As

Publication number Publication date
DD216454A5 (de) 1984-12-12
ES8600242A1 (es) 1985-10-01
FI831779A0 (fi) 1983-05-19
ES542185A0 (es) 1985-12-16
IS1380B6 (is) 1989-08-28
ES542187A0 (es) 1985-12-16
JPS58210064A (ja) 1983-12-07
EP0095450A2 (en) 1983-11-30
MW2083A1 (en) 1985-06-12
DD211554A5 (de) 1984-07-18
ES542186A0 (es) 1985-12-16
IL68604A0 (en) 1983-09-30
FI79300C (fi) 1989-12-11
HU193785B (en) 1987-11-30
GR78849B (es) 1984-10-02
KR900006116B1 (ko) 1990-08-22
ES8603417A1 (es) 1985-12-16
NZ204284A (en) 1985-11-08
NO162515B (no) 1989-10-02
PT76734A (en) 1983-06-01
ZA833264B (en) 1984-06-27
DK223783A (da) 1983-11-22
KR840004724A (ko) 1984-10-24
EP0095450A3 (en) 1984-09-05
IS2808A7 (is) 1983-11-22
ES522573A0 (es) 1985-10-01
GB2120251A (en) 1983-11-30
FI831779L (fi) 1983-11-22
HU188343B (en) 1986-04-28
GB2120251B (en) 1985-11-27
GB8314021D0 (en) 1983-06-29
PT76734B (en) 1986-03-27
NO162515C (no) 1990-01-10
NO831807L (no) 1983-11-22
FI79300B (fi) 1989-08-31
ES8603415A1 (es) 1985-12-16
CA1242201A (en) 1988-09-20
AU1464483A (en) 1983-11-24
DK223783D0 (da) 1983-05-19

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