ES8600242A1 - Un procedimiento para la preparacion de dihidropiridinas. - Google Patents
Un procedimiento para la preparacion de dihidropiridinas.Info
- Publication number
- ES8600242A1 ES8600242A1 ES522573A ES522573A ES8600242A1 ES 8600242 A1 ES8600242 A1 ES 8600242A1 ES 522573 A ES522573 A ES 522573A ES 522573 A ES522573 A ES 522573A ES 8600242 A1 ES8600242 A1 ES 8600242A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- intermediates
- therapeutically active
- compounds
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), EN LA QUE R1 SIGNIFICA UNO O DOS SUSTITUYENTES EN EL ANILLO FENILICO, SELECCIONADOS ENTRE NO2, C1 Y ALCOHILO INFERIOR; Y R ES -CH3.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE R1 TIENE EL SIGNIFICADO YA MENCIONADO; Y A ES -CH3.DE APLICACION COMO COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE OTRAS DIHIDROPIRIDINAS Y TAMBIEN SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES Y OTRAS AFECCIONES EN LAS QUE ES TERAPEUTICAMENTE IMPORTANTE LA RELAJACION DE LOS MUSCULOS LISOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8203177 | 1982-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8600242A1 true ES8600242A1 (es) | 1985-10-01 |
ES522573A0 ES522573A0 (es) | 1985-10-01 |
Family
ID=20346868
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522573A Granted ES522573A0 (es) | 1982-05-21 | 1983-05-20 | Un procedimiento para la preparacion de dihidropiridinas. |
ES542185A Expired ES8603415A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542186A Granted ES542186A0 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542187A Expired ES8603417A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542185A Expired ES8603415A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542186A Granted ES542186A0 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
ES542187A Expired ES8603417A1 (es) | 1982-05-21 | 1985-04-12 | Un procedimiento para preparar derivados de dihidropiridina |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0095450A3 (es) |
JP (1) | JPS58210064A (es) |
KR (1) | KR900006116B1 (es) |
AU (1) | AU1464483A (es) |
CA (1) | CA1242201A (es) |
DD (2) | DD211554A5 (es) |
DK (1) | DK223783A (es) |
ES (4) | ES522573A0 (es) |
FI (1) | FI79300C (es) |
GB (1) | GB2120251B (es) |
GR (1) | GR78849B (es) |
HU (2) | HU188343B (es) |
IL (1) | IL68604A0 (es) |
IS (1) | IS1380B6 (es) |
MW (1) | MW2083A1 (es) |
NO (1) | NO162515C (es) |
NZ (1) | NZ204284A (es) |
PT (1) | PT76734B (es) |
ZA (1) | ZA833264B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
IT1197012B (it) * | 1986-07-29 | 1988-11-25 | Boehringer Biochemia Srl | 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
IT1213440B (it) * | 1986-12-24 | 1989-12-20 | Boehringer Biochemia Srl | 2-ditioalchil-diidropiridine, un metodo per la loro preparazione e composizioni farmaceutiche chele contengono. |
IT1204948B (it) * | 1987-03-13 | 1989-03-10 | Boheringer Biochemia Robin S P | 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono. |
DE3741540A1 (de) * | 1987-12-08 | 1989-06-22 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen dihydropyridinen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
DE2740080A1 (de) * | 1977-09-06 | 1979-03-15 | Bayer Ag | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
GB2050375B (en) * | 1979-05-11 | 1983-02-23 | Fujisawa Pharmaceutical Co | 4-cyanophenyl-1,4-dihydropyridine compound processes for preparation thereof and pharmaceutical composition comprising the same |
SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
-
1983
- 1983-05-05 IL IL68604A patent/IL68604A0/xx unknown
- 1983-05-06 ZA ZA833264A patent/ZA833264B/xx unknown
- 1983-05-10 CA CA000427859A patent/CA1242201A/en not_active Expired
- 1983-05-13 EP EP83850126A patent/EP0095450A3/en not_active Withdrawn
- 1983-05-18 NZ NZ204284A patent/NZ204284A/en unknown
- 1983-05-18 AU AU14644/83A patent/AU1464483A/en not_active Abandoned
- 1983-05-18 MW MW20/83A patent/MW2083A1/xx unknown
- 1983-05-19 FI FI831779A patent/FI79300C/fi not_active IP Right Cessation
- 1983-05-19 DK DK223783A patent/DK223783A/da not_active Application Discontinuation
- 1983-05-19 GR GR71399A patent/GR78849B/el unknown
- 1983-05-20 JP JP58087769A patent/JPS58210064A/ja active Pending
- 1983-05-20 PT PT76734A patent/PT76734B/pt not_active IP Right Cessation
- 1983-05-20 GB GB08314021A patent/GB2120251B/en not_active Expired
- 1983-05-20 ES ES522573A patent/ES522573A0/es active Granted
- 1983-05-20 IS IS2808A patent/IS1380B6/is unknown
- 1983-05-20 NO NO831807A patent/NO162515C/no unknown
- 1983-05-20 HU HU831793A patent/HU188343B/hu not_active IP Right Cessation
- 1983-05-20 HU HU852490A patent/HU193785B/hu unknown
- 1983-05-20 DD DD83251136A patent/DD211554A5/de not_active IP Right Cessation
- 1983-05-20 DD DD83264593A patent/DD216454A5/de not_active IP Right Cessation
- 1983-05-21 KR KR1019830002236A patent/KR900006116B1/ko not_active IP Right Cessation
-
1985
- 1985-04-12 ES ES542185A patent/ES8603415A1/es not_active Expired
- 1985-04-12 ES ES542186A patent/ES542186A0/es active Granted
- 1985-04-12 ES ES542187A patent/ES8603417A1/es not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |