ES8801295A1 - Un procedimiento para preparar derivados de fosfina - Google Patents

Un procedimiento para preparar derivados de fosfina

Info

Publication number
ES8801295A1
ES8801295A1 ES553979A ES553979A ES8801295A1 ES 8801295 A1 ES8801295 A1 ES 8801295A1 ES 553979 A ES553979 A ES 553979A ES 553979 A ES553979 A ES 553979A ES 8801295 A1 ES8801295 A1 ES 8801295A1
Authority
ES
Spain
Prior art keywords
phosphine compounds
chem
inhibiting
therapy
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553979A
Other languages
English (en)
Other versions
ES553979A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8801295A1 publication Critical patent/ES8801295A1/es
Publication of ES553979A0 publication Critical patent/ES553979A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE FOSFINA. CONSISTE EN HACER REACCIONAR UN HETEROCICLO CON UN COMPUESTO DE FORMULA (II), EN UN DISOLVENTE ORGANICO NO REACTIVO QUE CONTIENE ETER ETILICO ANHIDRO Y UN REACTIVO ORGANOLITICO COMO N-BUTIL-LITIO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R, 2-PIRIDILO, 4-PIRIDILO; A, UNA CADENA ALCANODOILO LINEAL O RAMIFICADA DE C 1 A 6; X, CLORO, BROMO O TIOAZUCAR; Y M, 0 O 1. EL HETEROCICLO SE SELECCIONA ENTRE 4-PIRIDILO, 2-TIENILO Y 2-FURILO. SE UTILIZAN COMO ANTIARTRITICOS Y ANTITUMORALES.
ES553979A 1985-04-16 1986-04-15 Un procedimiento para preparar derivados de fosfina Expired ES8801295A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72377885A 1985-04-16 1985-04-16
US73452485A 1985-05-16 1985-05-16
US73601885A 1985-05-20 1985-05-20
US82935986A 1986-02-14 1986-02-14

Publications (2)

Publication Number Publication Date
ES8801295A1 true ES8801295A1 (es) 1987-12-16
ES553979A0 ES553979A0 (es) 1987-12-16

Family

ID=27505566

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553979A Expired ES8801295A1 (es) 1985-04-16 1986-04-15 Un procedimiento para preparar derivados de fosfina
ES557678A Expired ES8801296A1 (es) 1985-04-16 1987-08-17 Un procedimiento para preparar derivados organicos de fosforo y oro.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557678A Expired ES8801296A1 (es) 1985-04-16 1987-08-17 Un procedimiento para preparar derivados organicos de fosforo y oro.

Country Status (6)

Country Link
EP (1) EP0198696B1 (es)
DE (1) DE3670291D1 (es)
DK (1) DK166686A (es)
ES (2) ES8801295A1 (es)
FI (1) FI861557A (es)
NO (1) NO861461L (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8704181A1 (es) * 1985-01-22 1987-03-16 Smithkline Beckman Corp Un procedimiento para preparar un compuesto de bis (difenilfosfino) alquil -bis-oro-i
US4880902A (en) * 1987-08-27 1989-11-14 Shell Oil Company Copolymerization of carbon monoxide and olefin with diphosphine having heterocyclic substituents as catalyst
US5274125A (en) * 1991-03-15 1993-12-28 Hoffmann-La Roche Inc. Chirale phosphines
AU686918B2 (en) * 1994-12-09 1998-02-12 Griffith University Anti-tumour agents
AR105389A1 (es) * 2015-07-23 2017-09-27 Evonik Degussa Gmbh Compuestos basados en ferroceno y catalizadores de paladio basados en los mismos para la alcoxicarbonilación de compuestos etilénicamente instaurados

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238854A (en) * 1984-02-01 1988-07-05 David T. Hill ANTITUMOR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUMORS EMPLOYING ¬.alpha.,W- BIS(DISUBSTITUTEDPHOSPHINO)HYDROCARBON| DIGOLD (I) DIGOLD (III), DISILVER (I) AND DICOPPER (I) DERIVATIVES
PH21350A (en) * 1984-06-04 1987-10-13 Smithkline Beckman Corp Tumor cell growth imhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes

Also Published As

Publication number Publication date
DE3670291D1 (en) 1990-05-17
NO861461L (no) 1986-10-17
FI861557A (fi) 1986-10-17
FI861557A0 (fi) 1986-04-14
DK166686A (da) 1986-10-17
ES8801296A1 (es) 1987-12-16
EP0198696B1 (en) 1990-04-11
DK166686D0 (da) 1986-04-11
EP0198696A3 (en) 1988-01-07
EP0198696A2 (en) 1986-10-22
ES557678A0 (es) 1987-12-16
ES553979A0 (es) 1987-12-16

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