KR840007353A - 다중연질캡슐 및 그의 제조방법 - Google Patents

다중연질캡슐 및 그의 제조방법 Download PDF

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Publication number
KR840007353A
KR840007353A KR1019840000154A KR840000154A KR840007353A KR 840007353 A KR840007353 A KR 840007353A KR 1019840000154 A KR1019840000154 A KR 1019840000154A KR 840000154 A KR840000154 A KR 840000154A KR 840007353 A KR840007353 A KR 840007353A
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soft capsule
water
soluble
gelatin
film
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KR1019840000154A
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다까시 모리시다 (외 3)
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후지사와 도모기찌로
후지사와 야꾸힝 고교 가부시끼 가이샤 (외 1)
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Publication of KR840007353A publication Critical patent/KR840007353A/ko

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Seeds, Soups, And Other Foods (AREA)

Abstract

내용 없음.

Description

다중연질캡슐 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 다중연질캡슐을 제조하는 노즐부의 태양을 나타내는 도식적 수직단면도이며,
제3도 및 4도는 다중연질캡슐의 제조를 나타내는 도식적 공정도이다.

Claims (19)

  1. 외부연질캡슐내에 1종 이상의 내부캡슐이 외부캡슐액과 함게 함유된 다중연질캡슐.
  2. 의약품, 식품 또는 기호품인 특허청구범위 1의 다중연질캡슐.
  3. 내부 및/또는 외부 연질캡슐용 필림형성물질이 주로 젤란틴으로 이루어진 특허청구범위 1의 다중연질캡슐.
  4. 내부 및/또는 외부연질캡슐용 필림형성물질이 주로 (a) 젤란틴 및 (b) 수용성 다가알콜 또는 그 수용성 유도체로 이루어진 특허청구의 범위 제1항의 다중연질캡슐.
  5. 내부/및또는 연질캡슐용 필림형성물질이 주로 (a) 젤라틴, (b) 수용성 다가알콜 또는 그 수용성 유도체 및(c) 저메톡실펙틴 또는 소디움알기네이트를 함유하는 조성물을 이 저메톡실펙틴 또는 소디움알기네이트의 수용액을 겔화할 수 있는 화합물로 처리하여 얻어진 것인 특허청구의 범위 제1항의 다중연질캡슐.
  6. 수용성 다가알콜의 글리세린, 솔비트, 슈거에스테르 및 솔비탄에스테르로 이루어진 그룹에서 선택된 특허청구의 범위 제4 또는 5항의 다중연질캡슐.
  7. 저메톡실펙틴이 분자량 200,000 이하이고 메톡실화도가 1-6%인 특허청구의 범위 제5항의 다중연질캡슐.
  8. 젤란틴 및 수용성 다가알콜 또는 그 수용성 유도체의 량이 필림전체중량 기준으로 각각 60-90%(중량) 및 40-10%(중량)인 특허청구의 범위 제4항의 다중연질캡슐.
  9. 젤란틴, 저메톡실펙틴 및 수용성 다가알콜 또는 그 수용성 유도체의 량이 필림 전체중량의 기준으로 각각 65-70%(중량), 5-20%(중량) 및 10-30%(중량)인 특허청구의 범위 제5항의 다중연질캡슐.
  10. 젤란틴, 소디움알기네이트 및 수용성다가알콜 또는 그 수용성 유도체의 량이 필림 전체중량 기준으로 각각 65-80%(중량), 1-10%(중량) 및 10-30%(중량)인 특허청구의 범위 제5항의 다중연질캡슐.
  11. 외부연질캡슐이 위용성이고 내부연질캡슐이 장용성인 2중캡슐 구조를 가지는 특허청구의 범위 제1항의 다중연질캡슐.
  12. 외부연질캡슐내에 캡슐화될 내부연질캡술과 외부연질캡슐액을 함께 내부노즐이 환상공선단으로부터 압출하고, 동시에 외부연질캡슐용 외부필림형성액을 전술한 환상공 선단의 외부에 동심원상으로 배열된 외부노즐의 환상공선단으로부터 압출하여 형성된 복합젯트를 냉각액으로 방출시킴을 특징으로 하는 다중 연질캡슐을 제조하는 방법.
  13. 외부필림형성액이 주로 젤란틴을 포함하는 특허청구의 범위 제12항의 다중연질캡슐을 제조하는 방법.
  14. 외부필림형성액이 주로 (a) 젤란틴 및 (b) 수용성다가알콜 또는 그 수용성유도체를 포함하는 특허청구의 범위 제12항의 다중연질캡슐을 제조하는 방법.
  15. 외부필림형성액이 주로 (a) 젤란틴, (b) 수용성 다가알콜 또는 그 수용성유도체 및 (c) 저멕톡실펙틴 또는 소디움알기네이트로 이루어지고, 얻어진 다중연질캡슐을 전술한 다중연질캡슐을 전술한 저메톡실 펙틴 또는 소디움알기네이트의 수용액을 겔화할 수 있는 화합물로 더 처리하는 것을 특징으로 하는 특허청구의 범위 제12항의 다중연질캡슐을 제조하는 방법.
  16. 내부연질캡슐 충진용 내부캡슐액, 그 내부필림형성액, 외부연질캡슐 충진용 외부캡슐액 및 그 외부필림형성액을 순차적으로 증대하는 반경을 가지며, 동심원상으로 배열된 제1노즐, 제2노즐, 제3노즐 및 제4노즐로부터 각각 압출시켜서 형성된 다중젯트를 다음에 냉각액으로 방출하는 것을 특징으로 하는 다중 연질캡슐을 제조하는 방법.
  17. 내부필림형성액 및/또는 외부필림형성액이 주로 젤란틴을 포함하는 특허청구의 범위 제16항의 다중연질캡슐을 제조하는 방법.
  18. 내부 및/또는 외부필림형성액이 주로 (a) 젤란틴 및 (b) 수용성 다가알콜 또는 그 수용성 유도체를 포함하는 특허청구의 범위 제16항의 다중연질캡슐을 제조하는 방법.
  19. 외부필림형성액이 주로 (a) 젤란틴, (b) 수용성다가알콜 또는 그 수용성 유도체 및 (c) 저급메톡실 펙틴 또는 소디움알기네이트를 포함하며, 얻어진 다중연질캡슐을 전술한 저메톡실펙틴 또는 소디움알기네이트의 수용액을 겔화할 수 있는 화합물로 더 처리함을 특징으로 하는 특허청구의 범위 제16항의 다중연질캡슐을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000154A 1983-01-17 1984-01-16 다중연질캡슐 및 그의 제조방법 KR840007353A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6287 1983-01-17
JP58006287A JPS59131355A (ja) 1983-01-17 1983-01-17 多重軟カプセルの製法

Publications (1)

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KR840007353A true KR840007353A (ko) 1984-12-07

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Country Status (8)

Country Link
US (1) US4695466A (ko)
EP (1) EP0116311B1 (ko)
JP (1) JPS59131355A (ko)
KR (1) KR840007353A (ko)
AT (1) ATE43963T1 (ko)
CA (1) CA1241874A (ko)
DE (1) DE3478662D1 (ko)
ES (1) ES528899A0 (ko)

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KR100446118B1 (ko) * 1998-11-17 2004-08-30 에프. 호프만-라 로슈 아게 액체 충전된 캡슐의 제조 방법
KR100468335B1 (ko) * 1994-12-16 2005-09-02 워너-램버트 캄파니 엘엘씨 카플렛을캡슐로봉합하는방법및그방법으로얻을수있는고상투여형

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DE3478662D1 (en) 1989-07-20
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ATE43963T1 (de) 1989-06-15

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