KR840006644A - 1,4-디히드로피리딘 유도체 및 그제법 - Google Patents

1,4-디히드로피리딘 유도체 및 그제법 Download PDF

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Publication number
KR840006644A
KR840006644A KR1019830004886A KR830004886A KR840006644A KR 840006644 A KR840006644 A KR 840006644A KR 1019830004886 A KR1019830004886 A KR 1019830004886A KR 830004886 A KR830004886 A KR 830004886A KR 840006644 A KR840006644 A KR 840006644A
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South Korea
Prior art keywords
compound
general formula
diastereomer
represented
compound represented
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KR1019830004886A
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English (en)
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KR860001946B1 (ko
Inventor
겐지 또무오
Original Assignee
기노시다요시오
교오와핫 꼬오 고오교오 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from JP57180616A external-priority patent/JPS5970667A/ja
Priority claimed from JP58011719A external-priority patent/JPS59137461A/ja
Priority claimed from JP58098899A external-priority patent/JPS59225162A/ja
Application filed by 기노시다요시오, 교오와핫 꼬오 고오교오 가부시기가이샤 filed Critical 기노시다요시오
Publication of KR840006644A publication Critical patent/KR840006644A/ko
Priority to KR1019860008103A priority Critical patent/KR860001949B1/ko
Priority to KR1019860008102A priority patent/KR860001948B1/ko
Priority to KR1019860008104A priority patent/KR860001950B1/ko
Priority to KR1019860008105A priority patent/KR860001951B1/ko
Priority to KR1019860008101A priority patent/KR860001947B1/ko
Application granted granted Critical
Publication of KR860001946B1 publication Critical patent/KR860001946B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

내용 없음

Description

1,4-디히드로피리딘 유도체 및 그제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 그의 염산부가염의 융점이 196℃내지 202℃인 (±)-2, 6-디메틸-4-(3-니트로페닐)-1, 4-디히드로피리딘-3,5-디카르복시산-3-4-벤질-3-피페리닐)메스테르-5-메틸에스테르 또는 그의 염.
  2. 일반식(Ⅱ)로 표시된 화합물을 일반식(Ⅲ)으로 표시된 화합물과 반응시켜 일반식(Ⅰ)로 표시된 디아스테레오머를 얻는 단계와 상기 디아스테레오머를 분별결정시키는 단계로 되어 있는 것을 특징으로 하는, 제1항에 정의 된 화합물을 제조하는 방법.
  3. 일반식(Ⅴ)로 표시된 화합물을 일반식(Ⅳ)으로 표시된 화합물과 반응시켜 일반식(Ⅰ)로 표시된 디아스테레오머를 얻는 단계와 상기 디아스테레오머를 분별 결정시키는 단계로 되어 있는 것을 특징으로 하는, 제1항에 정의된 화합물을 제조하는 방법.
    상기식에서 Y는 할로겐원자를 표시함.
  4. 일반식(Ⅶ)로 표시된 화합물을 일반식(Ⅷ)로 표시된 화합물과 반응시켜 일반식(Ⅰ)로 표시되는 디아스테레오머를 얻는 단계와 상기 디아스테레오머를 분별결정시키는 것을 특징으로하는 제1항에서 정의된 화합물을 제조하는 방법.
    상기식에서, R1과 R2중의 하나는 메틸기를 표시하고 다른 것은 벤질피페리딜기를 표시한다.
  5. 일반식(Ⅶ)으로 표시된 화합물을 일반식(Ⅸ)으로 표시된 화합물 및 NH3(또는 암모늄염)반응시켜 일반식(Ⅰ)로 표시된 디아스테레오머를 얻는 단계와 상기 디아스테레오머를 분별결정시키는 단계로 되어 있는 것을 특징으로하는, 제1항에 정의된 화합물을 제조하는 방법.
    CH3COCH2CO2R2(IX)
    상기식에서 R1과 R2는 제4항에서 정의한 의미와 같다.
  6. 일반식(Ⅹ)으로 정의된 화합물을 일반식(Ⅸ)로 표시된 화합물 및 일반식(Ⅷ)로 표시된 화합물과 반응시켜 일반식(Ⅰ)로 표시된 디아스테레오머를 얻는 단계와 상기디아스테레오머를 분별결정시키는 단계로 되어 있는 것을 특징으로 하는 제1항에 정의된 화합물을 제조하는 방법.
    상기식에서 R1과 R2는 제4항에서 정의한 의미와 같다.
  7. 그의 염산부가염의 융점이 196내지 202℃인, (±)-2, 6-디메틸-4-(3-니트로페닐)-1, 4-디히드로피리딘-3,5-디카르복시산-3-(1-벤질-3-피페리딜)-에스테르-5-메틸메스테르 중에서 (+)성광도를 광학 이성체 또는 그의 염.
  8. 일반식(XIII)로 표시된 화합물을 일반식(XIV)으로 표시된 화합물과 반응시켜 일반식(XIII)로 표시된 화합물을 얻는 단계와, 화합물(XIII)과 화합물(XIV) 모두가 선광물질인 경우에는 통상적 방식에 의해, 또는 화합물(XII)이나 화합물(XIV)중의 어느것이 라세미 화합물인 경우에는 컬럼크로마토그래피에 의해서 제(7)항에서 정의한 화합물을 반응혼합물로부터 단리하는 단계로 되어 있는 것을 특징으로하는 제7항에 정의된 화합물을 제조하는 방법.
  9. 활성성분으로서 제1항에 정의된 화합물의 유효양과의 약담체로 되어 있는 것을 특징으로하는 의약조성물.
  10. 활성성분으로서 제7항에 정의된 화합물의 유효양과 의약담체로 되어 있는 것을 특징으로 하는 의약조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830004886A 1982-10-15 1983-10-15 1, 4-디히드로피리딘 유도체의 제조방법 KR860001946B1 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019860008103A KR860001949B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008102A KR860001948B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008104A KR860001950B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008105A KR860001951B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008101A KR860001947B1 (ko) 1982-10-15 1986-10-15 1,4-디히드로피리딘 유도체의 제조방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP57180616A JPS5970667A (ja) 1982-10-15 1982-10-15 １，４−ジヒドロピリジン誘導体
JP57-180616 1982-10-25
JP58011719A JPS59137461A (ja) 1983-01-27 1983-01-27 １，４−ジヒドロピリジン誘導体
JP58-11719 1983-01-27
JP58098899A JPS59225162A (ja) 1983-06-03 1983-06-03 １，４−ジヒドロピリジン誘導体
JP58-98899 1983-06-03

Related Child Applications (5)

Application Number Title Priority Date Filing Date
KR1019860008105A Division KR860001951B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008103A Division KR860001949B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008102A Division KR860001948B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008104A Division KR860001950B1 (ko) 1982-10-15 1986-09-27 1,4-디히드로피리딘 유도체의 제조방법
KR1019860008101A Division KR860001947B1 (ko) 1982-10-15 1986-10-15 1,4-디히드로피리딘 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR840006644A true KR840006644A (ko) 1984-12-01
KR860001946B1 KR860001946B1 (ko) 1986-11-01

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ID=27279541

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Application Number Title Priority Date Filing Date
KR1019830004886A KR860001946B1 (ko) 1982-10-15 1983-10-15 1, 4-디히드로피리딘 유도체의 제조방법

Country Status (7)

Country Link
EP (1) EP0106275B1 (ko)
KR (1) KR860001946B1 (ko)
AU (1) AU557175B2 (ko)
CA (1) CA1246078A (ko)
DE (1) DE3382204D1 (ko)
ES (1) ES8600273A1 (ko)
MX (1) MX156034A (ko)

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IT1204336B (it) * 1986-05-05 1989-03-01 Luso Farmaco Inst Processo per la preparazione di 2-(n-benzil-n-metilammino)-etil-metil1,4-diidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridin-dicarbossilato cloridrato
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
RS20050106A (en) 2002-08-19 2007-11-15 Pfizer Products Inc., Combination therapy for hyperproliferative diseases
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN102746215A (zh) * 2011-04-18 2012-10-24 张兆勇 一种制备高纯度盐酸贝尼地平的方法
CN102351784B (zh) * 2011-10-20 2013-10-30 华夏药业集团有限公司 一种盐酸贝尼地平晶型及其应用
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103641774B (zh) * 2013-11-26 2015-07-08 湖南方盛制药股份有限公司 盐酸贝尼地平的制备方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104529872B (zh) * 2014-12-10 2018-07-10 天津长源医药科技有限公司 一种盐酸贝尼地平中间体的合成方法
WO2019053491A1 (en) 2017-09-15 2019-03-21 Deva Holding Anonim Sirketi CRYSTALLINE BENIDIPINE HCL SOLID FORMS AND PROCESSES FOR PREPARING THE SAME
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
CN112679416A (zh) * 2020-12-31 2021-04-20 济南朗科医药技术有限公司 一种盐酸贝尼地平的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2659665A1 (de) * 1976-12-30 1978-07-13 Nattermann A & Cie Neue 1,4-dihydropyridin-derivate
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
EP0106275A2 (en) 1984-04-25
ES526441A0 (es) 1985-10-01
DE3382204D1 (de) 1991-04-18
ES8600273A1 (es) 1985-10-01
CA1246078A (en) 1988-12-06
EP0106275A3 (en) 1984-05-23
MX156034A (es) 1988-06-16
AU557175B2 (en) 1986-12-11
AU1989883A (en) 1984-04-19
KR860001946B1 (ko) 1986-11-01
EP0106275B1 (en) 1991-03-13

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