ES526441A0 - Un procedimiento para producir 2,6-dimetil-4-(3nitrofenil)-1,4-dihidropiridin 3,5-dicarboxilato de 1, bencil-3-piperidilo y metilo y su hidrocloruro. - Google Patents
Un procedimiento para producir 2,6-dimetil-4-(3nitrofenil)-1,4-dihidropiridin 3,5-dicarboxilato de 1, bencil-3-piperidilo y metilo y su hidrocloruro.Info
- Publication number
- ES526441A0 ES526441A0 ES526441A ES526441A ES526441A0 ES 526441 A0 ES526441 A0 ES 526441A0 ES 526441 A ES526441 A ES 526441A ES 526441 A ES526441 A ES 526441A ES 526441 A0 ES526441 A0 ES 526441A0
- Authority
- ES
- Spain
- Prior art keywords
- piperidilo
- dihidropiridin
- dicarboxilato
- bencil
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57180616A JPS5970667A (ja) | 1982-10-15 | 1982-10-15 | １，４−ジヒドロピリジン誘導体 |
| JP58011719A JPS59137461A (ja) | 1983-01-27 | 1983-01-27 | １，４−ジヒドロピリジン誘導体 |
| JP58098899A JPS59225162A (ja) | 1983-06-03 | 1983-06-03 | １，４−ジヒドロピリジン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES526441A0 true ES526441A0 (es) | 1985-10-01 |
| ES8600273A1 ES8600273A1 (es) | 1985-10-01 |
Family
ID=27279541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526441A Expired ES8600273A1 (es) | 1982-10-15 | 1983-10-13 | Un procedimiento para producir 2,6-dimetil-4-(3nitrofenil)-1,4-dihidropiridin 3,5-dicarboxilato de 1, bencil-3-piperidilo y metilo y su hidrocloruro. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0106275B1 (es) |
| KR (1) | KR860001946B1 (es) |
| AU (1) | AU557175B2 (es) |
| CA (1) | CA1246078A (es) |
| DE (1) | DE3382204D1 (es) |
| ES (1) | ES8600273A1 (es) |
| MX (1) | MX156034A (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1204336B (it) * | 1986-05-05 | 1989-03-01 | Luso Farmaco Inst | Processo per la preparazione di 2-(n-benzil-n-metilammino)-etil-metil1,4-diidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridin-dicarbossilato cloridrato |
| FR2671349B1 (fr) * | 1991-01-09 | 1993-04-23 | Lafon Labor | Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant. |
| CN1681495B (zh) | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | 用于治疗过度增生性疾病的组合物 |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| JP2009513660A (ja) | 2005-10-26 | 2009-04-02 | 旭化成ファーマ株式会社 | 肺動脈性高血圧の治療用併用療法におけるファスジル |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| CN102746215A (zh) * | 2011-04-18 | 2012-10-24 | 张兆勇 | 一种制备高纯度盐酸贝尼地平的方法 |
| CN102351784B (zh) * | 2011-10-20 | 2013-10-30 | 华夏药业集团有限公司 | 一种盐酸贝尼地平晶型及其应用 |
| BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
| CN103641774B (zh) * | 2013-11-26 | 2015-07-08 | 湖南方盛制药股份有限公司 | 盐酸贝尼地平的制备方法 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN104529872B (zh) * | 2014-12-10 | 2018-07-10 | 天津长源医药科技有限公司 | 一种盐酸贝尼地平中间体的合成方法 |
| WO2019053491A1 (en) | 2017-09-15 | 2019-03-21 | Deva Holding Anonim Sirketi | CRYSTALLINE BENIDIPINE HCL SOLID FORMS AND PROCESSES FOR PREPARING THE SAME |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| CN112679416A (zh) * | 2020-12-31 | 2021-04-20 | 济南朗科医药技术有限公司 | 一种盐酸贝尼地平的制备方法 |
| CN118993991B (zh) * | 2024-07-25 | 2025-09-23 | 苏州东瑞制药有限公司 | 一种盐酸贝尼地平副产物回收利用的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2659665A1 (de) * | 1976-12-30 | 1978-07-13 | Nattermann A & Cie | Neue 1,4-dihydropyridin-derivate |
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
-
1983
- 1983-10-05 AU AU19898/83A patent/AU557175B2/en not_active Expired
- 1983-10-05 EP EP19830109968 patent/EP0106275B1/en not_active Expired - Lifetime
- 1983-10-05 DE DE8383109968T patent/DE3382204D1/de not_active Expired - Lifetime
- 1983-10-13 ES ES526441A patent/ES8600273A1/es not_active Expired
- 1983-10-14 CA CA000438995A patent/CA1246078A/en not_active Expired
- 1983-10-14 MX MX199109A patent/MX156034A/es unknown
- 1983-10-15 KR KR1019830004886A patent/KR860001946B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3382204D1 (de) | 1991-04-18 |
| ES8600273A1 (es) | 1985-10-01 |
| EP0106275A3 (en) | 1984-05-23 |
| CA1246078A (en) | 1988-12-06 |
| EP0106275B1 (en) | 1991-03-13 |
| KR860001946B1 (ko) | 1986-11-01 |
| KR840006644A (ko) | 1984-12-01 |
| AU1989883A (en) | 1984-04-19 |
| AU557175B2 (en) | 1986-12-11 |
| EP0106275A2 (en) | 1984-04-25 |
| MX156034A (es) | 1988-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050613 |