MX156034A - Procidiemento para preparar el 3-ester-(ibencil-3-piperidil)-5-metil-ester, del acido 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilico - Google Patents

Procidiemento para preparar el 3-ester-(ibencil-3-piperidil)-5-metil-ester, del acido 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilico

Info

Publication number
MX156034A
MX156034A MX199109A MX19910983A MX156034A MX 156034 A MX156034 A MX 156034A MX 199109 A MX199109 A MX 199109A MX 19910983 A MX19910983 A MX 19910983A MX 156034 A MX156034 A MX 156034A
Authority
MX
Mexico
Prior art keywords
ester
ibencil
dihidropiridin
dicarboxilico
nitrofenil
Prior art date
Application number
MX199109A
Other languages
English (en)
Inventor
Kenji Muto
Tokuyuki Kuroda
Akira Karasawa
Koji Yamada
Nobuhiro Nakamizo
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57180616A external-priority patent/JPS5970667A/ja
Priority claimed from JP58011719A external-priority patent/JPS59137461A/ja
Priority claimed from JP58098899A external-priority patent/JPS59225162A/ja
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of MX156034A publication Critical patent/MX156034A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/42Oxygen atoms attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX199109A 1982-10-15 1983-10-14 Procidiemento para preparar el 3-ester-(ibencil-3-piperidil)-5-metil-ester, del acido 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilico MX156034A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP57180616A JPS5970667A (ja) 1982-10-15 1982-10-15 1,4−ジヒドロピリジン誘導体
JP58011719A JPS59137461A (ja) 1983-01-27 1983-01-27 1,4−ジヒドロピリジン誘導体
JP58098899A JPS59225162A (ja) 1983-06-03 1983-06-03 1,4−ジヒドロピリジン誘導体

Publications (1)

Publication Number Publication Date
MX156034A true MX156034A (es) 1988-06-16

Family

ID=27279541

Family Applications (1)

Application Number Title Priority Date Filing Date
MX199109A MX156034A (es) 1982-10-15 1983-10-14 Procidiemento para preparar el 3-ester-(ibencil-3-piperidil)-5-metil-ester, del acido 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilico

Country Status (7)

Country Link
EP (1) EP0106275B1 (es)
KR (1) KR860001946B1 (es)
AU (1) AU557175B2 (es)
CA (1) CA1246078A (es)
DE (1) DE3382204D1 (es)
ES (1) ES526441A0 (es)
MX (1) MX156034A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204336B (it) * 1986-05-05 1989-03-01 Luso Farmaco Inst Processo per la preparazione di 2-(n-benzil-n-metilammino)-etil-metil1,4-diidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridin-dicarbossilato cloridrato
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
CN102746215A (zh) * 2011-04-18 2012-10-24 张兆勇 一种制备高纯度盐酸贝尼地平的方法
CN102351784B (zh) * 2011-10-20 2013-10-30 华夏药业集团有限公司 一种盐酸贝尼地平晶型及其应用
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
CN103641774B (zh) * 2013-11-26 2015-07-08 湖南方盛制药股份有限公司 盐酸贝尼地平的制备方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104529872B (zh) * 2014-12-10 2018-07-10 天津长源医药科技有限公司 一种盐酸贝尼地平中间体的合成方法
WO2019053491A1 (en) 2017-09-15 2019-03-21 Deva Holding Anonim Sirketi CRYSTALLINE BENIDIPINE HCL SOLID FORMS AND PROCESSES FOR PREPARING THE SAME
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
CN112679416A (zh) * 2020-12-31 2021-04-20 济南朗科医药技术有限公司 一种盐酸贝尼地平的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2659665A1 (de) * 1976-12-30 1978-07-13 Nattermann A & Cie Neue 1,4-dihydropyridin-derivate
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
DE3382204D1 (de) 1991-04-18
EP0106275A3 (en) 1984-05-23
EP0106275A2 (en) 1984-04-25
AU1989883A (en) 1984-04-19
EP0106275B1 (en) 1991-03-13
ES8600273A1 (es) 1985-10-01
ES526441A0 (es) 1985-10-01
AU557175B2 (en) 1986-12-11
CA1246078A (en) 1988-12-06
KR860001946B1 (ko) 1986-11-01
KR840006644A (ko) 1984-12-01

Similar Documents

Publication Publication Date Title
MX156034A (es) Procidiemento para preparar el 3-ester-(ibencil-3-piperidil)-5-metil-ester, del acido 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilico
ES528577A0 (es) Procedimiento para preparar acidos 4-fenil-1,3-dioxan-cis-5-ilalquenoicos
ES519423A0 (es) Procedimiento para preparar 9-(1 o 3-monoaciloxi-o 1,3-diaciloxi-2-propoximetil)-purinas substituidas en calidad de agentes antiviricos.
ES515426A0 (es) Procedimiento para la obtencion de compuestos del acido 7 b-aminotiadiazolilacetilamino-3-amoniometil-3-cefem-4-carboxilico.
AR226354A1 (es) Procedimiento para preparar el complejo cis-isocitrato(1,2-diamino ciclohexano)plation
ES520112A0 (es) Un procedimiento para preparar amidas del acido 1-metil-5-p-toluoilpirrol-2-acetico.
ES521337A0 (es) Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico.
ES523064A0 (es) Procedimiento para preparar azetidinas.
ES520323A0 (es) Un procedimiento mejorado para preparar acido 2-ceto-l-gulonico.
ES510330A0 (es) Procedimiento para preparar etilenglicol.
ES500032A0 (es) Un procedimiento para la preparacion de derivados del acido 7-oxo-1-azabiciclo (3,2,0) hept-2-en-2-carboxilico.
ES525186A0 (es) Procedimiento para preparar nuevas imidazo-(1,2-a)-pirimidinas
ES520531A0 (es) Procedimiento para preparar tioeteres.
ES521813A0 (es) Procedimiento para preparar alcohil-polisacaridos.
ES501124A0 (es) Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10-14-hexadecapentaenoico.
ES523664A0 (es) Procedimiento para la preparacion de nuevos derivados del acido quinolicincarboxilico.
ES530388A0 (es) Procedimiento para preparar derivados del 2-azabiciclo-2.2.1-heptano.
ES512387A0 (es) "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico".
ES518912A0 (es) Un procedimiento para la preparacion de derivados del acido penicilanico.
ES511759A0 (es) Procedimiento para preparar derivados del acido 1,4-tiazan-3-carboxilico.
ES521398A0 (es) Procedimiento para preparar indolaminas sustituidas.
ES524579A0 (es) Procedimiento para preparar nitrometano.
ES532108A0 (es) Procedimiento para preparar 9-(1 o 3-monoaciloxi-o 1,3-diaciloxi-2-propoximetil)-purinas substituidas en calidad de agentes antiviricos.
ES521154A0 (es) Procedimiento de preparacion del acido p-bifenilil-4-oxo-4-metil-2-butirico.
ES495620A0 (es) Procedimiento para preparar derivados del acido 2,7-fenan- trolina-9-carboxilico