ES532710A0 - Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina - Google Patents
Un procedimiento para producir 3-(3, 4-dihidroxifenil) serinaInfo
- Publication number
- ES532710A0 ES532710A0 ES532710A ES532710A ES532710A0 ES 532710 A0 ES532710 A0 ES 532710A0 ES 532710 A ES532710 A ES 532710A ES 532710 A ES532710 A ES 532710A ES 532710 A0 ES532710 A0 ES 532710A0
- Authority
- ES
- Spain
- Prior art keywords
- dihidroxifenil
- serina
- procedure
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58092941A JPS59216858A (ja) | 1983-05-25 | 1983-05-25 | スレオ−３−（３，４−ジヒドロキシフエニル）セリンの製造法 |
| JP2782884A JPS60169452A (ja) | 1984-02-15 | 1984-02-15 | エリスロ−３−（３，４−ジヒドロキシフエニル）セリンの製造法 |
| JP59027827A JPS60169462A (ja) | 1984-02-15 | 1984-02-15 | 光学活性なフエニルセリン誘導体の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532710A0 true ES532710A0 (es) | 1985-10-16 |
| ES8601100A1 ES8601100A1 (es) | 1985-10-16 |
Family
ID=27285964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532710A Expired ES8601100A1 (es) | 1983-05-25 | 1984-05-23 | Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4562263A (es) |
| EP (1) | EP0128684B1 (es) |
| CA (1) | CA1223602A (es) |
| DE (1) | DE3468679D1 (es) |
| ES (1) | ES8601100A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6259274A (ja) * | 1985-05-29 | 1987-03-14 | Sumitomo Pharmaceut Co Ltd | 光学活性なフエニルセリン誘導体の製造方法 |
| JPS62192357A (ja) * | 1986-02-19 | 1987-08-22 | Kureha Chem Ind Co Ltd | Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法 |
| US5294737A (en) * | 1992-02-27 | 1994-03-15 | The Research Foundation State University Of New York | Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom |
| WO1997003989A1 (en) * | 1995-07-24 | 1997-02-06 | Takeda Chemical Industries, Ltd. | Production of optically active benzothiepin salts |
| MY117687A (en) * | 1996-10-31 | 2004-07-31 | Bayer Corp | Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors |
| US6403645B2 (en) | 2000-03-16 | 2002-06-11 | President And Fellows Of Harvard College | Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them |
| JP2005518338A (ja) * | 2001-08-17 | 2005-06-23 | デグサ アクチエンゲゼルシャフト | Ｓｍｂ−法を用いた、保護アミノ酸エナンチオマーのクロマトグラフィーによる分離 |
| WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
| US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
| WO2005025561A1 (en) * | 2003-09-04 | 2005-03-24 | Synergia Pharma, Inc. | Compositions and methods for orthostatic intolerance |
| DK1948155T3 (da) * | 2006-06-28 | 2012-07-02 | Chelsea Therapeutics Inc | Farmaceutiske præparater omfattende droxidopa |
| AU2008226541B2 (en) | 2007-03-09 | 2013-05-09 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia |
| CA2686723A1 (en) * | 2007-05-07 | 2008-11-13 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders |
| WO2011001976A1 (ja) * | 2009-07-01 | 2011-01-06 | 大日本住友製薬株式会社 | スレオ－３－（３，４－ジヒドロキシフェニル）－ｌ－セリンの製造法 |
| JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状（姿勢反射異常）の治療剤 |
| SG11201404496PA (en) | 2012-01-31 | 2014-12-30 | Lundbeck Na Ltd | Improving postural stability administering droxidopa |
| WO2013142093A1 (en) | 2012-03-20 | 2013-09-26 | Chelsea Therapeutics, Inc. | Method for the synthesis of droxidopa |
| EP3611159B1 (en) | 2013-07-08 | 2023-01-25 | Auspex Pharmaceuticals, Inc. | Dihydroxyphenyl neurotransmitter compounds, compositions and methods |
| US11447443B2 (en) | 2016-03-30 | 2022-09-20 | Piramal Pharma Limited | Process for the preparation of droxidopa and its intermediate |
| US9920342B2 (en) | 2016-05-17 | 2018-03-20 | Divi's Laboratories Limited | Process for the preparation of Droxidopa |
| CN113773297B (zh) * | 2017-12-25 | 2023-12-26 | 重庆圣华曦药业股份有限公司 | 屈昔多巴关键中间体的拆分方法 |
| EP3587393B1 (en) | 2018-06-21 | 2024-01-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Enzymatic process for the preparation of droxidopa |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT205027B (de) * | 1957-07-18 | 1959-08-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur Herstellung von neuen α-Aroyl-α-phthaliminoessigsäureestern |
| CH505785A (de) * | 1969-02-07 | 1971-04-15 | Hoffmann La Roche | Verfahren zur Herstellung von (-)threo-3-(4-Hydroxy-3-methoxy-phenyl)-serin |
| CH580059A5 (es) * | 1973-08-22 | 1976-09-30 | Hoffmann La Roche | |
| GB1585061A (en) * | 1977-03-15 | 1981-02-25 | Nat Res Dev | Synthesis of peptides |
| JPS5419931A (en) * | 1977-07-11 | 1979-02-15 | Sumitomo Chem Co Ltd | Separation of threo, erythro-3-(3,4-dibenzyloxyphenyl)serines |
| DD140036A1 (de) * | 1978-05-03 | 1987-02-11 | Adw Ddr | Verfahren zur herstellung optisch aktiver aminosaeuren und ihrer derivate |
| FR2430413A1 (fr) * | 1978-07-07 | 1980-02-01 | Anvar | Procede de preparation d'alpha-aminoacides optiquement actifs, et leurs derives |
| JPS5629551A (en) * | 1979-08-20 | 1981-03-24 | Sumitomo Chem Co Ltd | Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine |
| EP0084928B1 (en) * | 1982-01-14 | 1985-09-11 | Sumitomo Chemical Company, Limited | Process for producing threo-3-(3,4-dihydroxyphenyl)serine |
-
1984
- 1984-05-22 CA CA000454819A patent/CA1223602A/en not_active Expired
- 1984-05-23 ES ES532710A patent/ES8601100A1/es not_active Expired
- 1984-05-24 DE DE8484303513T patent/DE3468679D1/de not_active Expired
- 1984-05-24 EP EP84303513A patent/EP0128684B1/en not_active Expired
- 1984-05-25 US US06/614,246 patent/US4562263A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0128684B1 (en) | 1988-01-13 |
| DE3468679D1 (en) | 1988-02-18 |
| CA1223602A (en) | 1987-06-30 |
| EP0128684A1 (en) | 1984-12-19 |
| ES8601100A1 (es) | 1985-10-16 |
| US4562263A (en) | 1985-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20030312 |