DE3468679D1 - Process for producing 3-(3,4-dihydroxyphenyl) serine - Google Patents

Process for producing 3-(3,4-dihydroxyphenyl) serine

Info

Publication number
DE3468679D1
DE3468679D1 DE8484303513T DE3468679T DE3468679D1 DE 3468679 D1 DE3468679 D1 DE 3468679D1 DE 8484303513 T DE8484303513 T DE 8484303513T DE 3468679 T DE3468679 T DE 3468679T DE 3468679 D1 DE3468679 D1 DE 3468679D1
Authority
DE
Germany
Prior art keywords
dihydroxyphenyl
serine
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484303513T
Other languages
English (en)
Inventor
Naohito Ohashi
Shoji Nagata
Kikuo Ishizumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58092941A external-priority patent/JPS59216858A/ja
Priority claimed from JP2782884A external-priority patent/JPS60169452A/ja
Priority claimed from JP59027827A external-priority patent/JPS60169462A/ja
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of DE3468679D1 publication Critical patent/DE3468679D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DE8484303513T 1983-05-25 1984-05-24 Process for producing 3-(3,4-dihydroxyphenyl) serine Expired DE3468679D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58092941A JPS59216858A (ja) 1983-05-25 1983-05-25 スレオ−３−（３，４−ジヒドロキシフエニル）セリンの製造法
JP2782884A JPS60169452A (ja) 1984-02-15 1984-02-15 エリスロ−３−（３，４−ジヒドロキシフエニル）セリンの製造法
JP59027827A JPS60169462A (ja) 1984-02-15 1984-02-15 光学活性なフエニルセリン誘導体の製造法

Publications (1)

Publication Number Publication Date
DE3468679D1 true DE3468679D1 (en) 1988-02-18

Family

ID=27285964

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484303513T Expired DE3468679D1 (en) 1983-05-25 1984-05-24 Process for producing 3-(3,4-dihydroxyphenyl) serine

Country Status (5)

Country Link
US (1) US4562263A (de)
EP (1) EP0128684B1 (de)
CA (1) CA1223602A (de)
DE (1) DE3468679D1 (de)
ES (1) ES532710A0 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6259274A (ja) * 1985-05-29 1987-03-14 Sumitomo Pharmaceut Co Ltd 光学活性なフエニルセリン誘導体の製造方法
JPS62192357A (ja) * 1986-02-19 1987-08-22 Kureha Chem Ind Co Ltd Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
AU6471896A (en) * 1995-07-24 1997-02-18 Takeda Chemical Industries Ltd. Production of optically active benzothiepin salts
MY117687A (en) * 1996-10-31 2004-07-31 Bayer Corp Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors
US6403645B2 (en) 2000-03-16 2002-06-11 President And Fellows Of Harvard College Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them
JP2005518338A (ja) * 2001-08-17 2005-06-23 デグサ アクチエンゲゼルシャフト Ｓｍｂ−法を用いた、保護アミノ酸エナンチオマーのクロマトグラフィーによる分離
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
WO2004100929A1 (en) 2003-05-12 2004-11-25 Synergia Pharma, Inc. Threo-dops controlled release formulation
WO2005025561A1 (en) * 2003-09-04 2005-03-24 Synergia Pharma, Inc. Compositions and methods for orthostatic intolerance
ES2571730T3 (es) 2006-06-28 2016-05-26 Lundbeck Na Ltd Composiciones farmacéuticas que comprenden droxidopa
ES2500053T3 (es) * 2007-03-09 2014-09-29 Chelsea Therapeutics, Inc. Composición farmacéutica que comprende droxidopa para el tratamiento de la fibromialgia
NZ581707A (en) * 2007-05-07 2011-05-27 Chelsea Therapeutics Inc Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
EP2450343A4 (de) * 2009-07-01 2013-01-09 Dainippon Sumitomo Pharma Co Verfahren zur herstellung von threo-3-(3,4-dihydroxyphenyl)-l-serin
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状（姿勢反射異常）の治療剤
US20130197090A1 (en) 2012-01-31 2013-08-01 Chelsea Therapeutics, Inc. Postural stability and incident functions in patients
WO2013142093A1 (en) 2012-03-20 2013-09-26 Chelsea Therapeutics, Inc. Method for the synthesis of droxidopa
SG11201510764QA (en) 2013-07-08 2016-01-28 Auspex Pharmaceuticals Inc Dihydroxyphenyl neurotransmitter compounds, compositions and methods
US11447443B2 (en) 2016-03-30 2022-09-20 Piramal Pharma Limited Process for the preparation of droxidopa and its intermediate
US9920342B2 (en) 2016-05-17 2018-03-20 Divi's Laboratories Limited Process for the preparation of Droxidopa
CN113773297B (zh) * 2017-12-25 2023-12-26 重庆圣华曦药业股份有限公司 屈昔多巴关键中间体的拆分方法
EP3587393B1 (de) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatisches verfahren zur herstellung von droxidopa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT205027B (de) * 1957-07-18 1959-08-25 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von neuen α-Aroyl-α-phthaliminoessigsäureestern
CH505785A (de) * 1969-02-07 1971-04-15 Hoffmann La Roche Verfahren zur Herstellung von (-)threo-3-(4-Hydroxy-3-methoxy-phenyl)-serin
CH580059A5 (de) * 1973-08-22 1976-09-30 Hoffmann La Roche
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
JPS5419931A (en) * 1977-07-11 1979-02-15 Sumitomo Chem Co Ltd Separation of threo, erythro-3-(3,4-dibenzyloxyphenyl)serines
DD140036A1 (de) * 1978-05-03 1987-02-11 Adw Ddr Verfahren zur herstellung optisch aktiver aminosaeuren und ihrer derivate
FR2430413A1 (fr) * 1978-07-07 1980-02-01 Anvar Procede de preparation d'alpha-aminoacides optiquement actifs, et leurs derives
JPS5629551A (en) * 1979-08-20 1981-03-24 Sumitomo Chem Co Ltd Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine
DE3360726D1 (en) * 1982-01-14 1985-10-17 Sumitomo Chemical Co Process for producing threo-3-(3,4-dihydroxyphenyl)serine

Also Published As

Publication number Publication date
CA1223602A (en) 1987-06-30
ES8601100A1 (es) 1985-10-16
EP0128684B1 (de) 1988-01-13
US4562263A (en) 1985-12-31
ES532710A0 (es) 1985-10-16
EP0128684A1 (de) 1984-12-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee