KR840004076A - 티오메틸 파리딘 유도체의 제조방법 - Google Patents

티오메틸 파리딘 유도체의 제조방법 Download PDF

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KR840004076A
KR840004076A KR1019830001178A KR830001178A KR840004076A KR 840004076 A KR840004076 A KR 840004076A KR 1019830001178 A KR1019830001178 A KR 1019830001178A KR 830001178 A KR830001178 A KR 830001178A KR 840004076 A KR840004076 A KR 840004076A
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South Korea
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group
thiomethyl
pyridine
producing
derivative
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KR1019830001178A
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English (en)
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KR860001578B1 (ko
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쉬크카네데르 헬멋트
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원본미기재
루드윅 휴만 앤드 컴패니 게엠베하
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Publication of KR840004076A publication Critical patent/KR840004076A/ko
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Publication of KR860001578B1 publication Critical patent/KR860001578B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

내용 없음

Description

티오메틸 피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 알칼리 금속 수산화물이 화학량론적 양 이상으로 존재하는 수성-알코올성 알칼리 금속 수산화물 용액내에서 다음 식(Ⅲ)의 티올산염과 다음 식(Ⅳ)의 염화피클일 히드로할라이드를 반응시켜서 다음 식(Ⅰ)의 티오메틸피리딘 유도체들을 제조한 후, 경우에 따라서 이 반응에 의하여 수득된 최종 유리염기를 치료학적으로 -수락할 수 있는 산성부가염으로 전환시킴을 특징으로 하는 티오메틸피리딘 유도체의 제조방법.
    이 식에서 R은 피리딘고리의 2, -3- 또는 4-위치에 부착되는 Q-S-CH2-기 (Q는 치환되었거나 치환되지 않은 아릴기이거나 또는 한 개 이상의 치환체를 함유할 수 있거나 임의로 치환된 페닐기나 임의로 치환된 헤테로고리와 축합될 수도 있는 5- 또는 6-원형의 헤테로 고리형태로된 기이다)이고;
    R'는 저급알킬기이거나 할로겐원자 또는 아미노알킬기이며;
    n은 0 또는 1-4까지의 정수이다.
    Q-SMn (Ⅲ)
    이 식에서 Q는 식(Ⅰ)에서 정의한 바와 같고; Me는 알칼리 금속원자이다.
    이 식에서 Hal은 할로겐원자를 나타내며; 클로로메틸기는 피리딘고리의 2-, 3- 또는 4-위치에 있으며, R'와 n은 식(Ⅰ)에서 정의한 바와 같다.
  2. 제1항에 있어서, n이 0인 티오메틸피리딘 유도체를 제조함을 특징으로 하는 티오메틸피리딘 유도체의 제조방법.
  3. 제1항에 있어서, n이 1이고, R'가 피리딘고 리중 6-위치에 부착되어 있는 티오메틸 피리딘 유도체를 제조함을 특징으로 하는 티오메틸 피리딘 유도체의 제조방법.
  4. 제1항에 있어서, n이 2이고, R'가 피리딘고리중 5- 와 6-위치에 부착되어 있는 티오메틸 피리딘 유도체를 제조함을 특징으로 하는 티오메틸 피리딘 유도체의 제조방법.
  5. 제1항에 있어서, Q가 임의로 치환된 페닐기인 티오메틸 피리딘 유도체를 제조함을 특징으로 하는 티오메틸 피리딘 유도체의 제조방법.
  6. 제5항에 있어서, 할로겐원자나 저급알킬기 또는 저급알콕시기가 페닐기중 P-위치에 치환됨을 특징으로 하는 티오메틸 피리딘 유도체의 제조방법.
  7. 제1항에 있어서, Q가 임의로 치환된 이미다졸 일기, 티아졸일기, 티에닐기, 옥사졸일기, 피리미딘일기 또는 피리딜기인 티오메틸 피리딘 유도체를 제조함을 특징으로 하는 티오메틸 피리딘 유도체의 제조방법.
  8. 제7항에 있어서, 이미다졸일기, 티아졸일기, 티에닐기, 옥사졸일기, 피리미딘일기 또는 피리미딜기가 저급알킬기와 할로겐원자 및 알콕시기 등으로 이루어진 기중에서 선택한 한 개나 두 개의 치환제로 치환됨을 특징으로한 티오메틸 피리딘 유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001178A 1982-05-05 1983-03-24 3-티오메틸 파리딘 유도체의 제조방법 KR860001578B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3216843A DE3216843C2 (de) 1982-05-05 1982-05-05 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3216843.8 1982-05-05
DE32168438 1982-05-05

Publications (2)

Publication Number Publication Date
KR840004076A true KR840004076A (ko) 1984-10-06
KR860001578B1 KR860001578B1 (ko) 1986-10-10

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Family Applications (1)

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KR1019830001178A KR860001578B1 (ko) 1982-05-05 1983-03-24 3-티오메틸 파리딘 유도체의 제조방법

Country Status (19)

Country Link
US (2) US4866066A (ko)
EP (1) EP0093252B1 (ko)
JP (1) JPS58203965A (ko)
KR (1) KR860001578B1 (ko)
AT (1) ATE32894T1 (ko)
AU (1) AU565518B2 (ko)
CA (1) CA1213279A (ko)
DD (1) DD208801A5 (ko)
DE (2) DE3216843C2 (ko)
DK (1) DK160500C (ko)
ES (1) ES8401755A1 (ko)
GR (1) GR78961B (ko)
HU (1) HU189272B (ko)
IE (1) IE55263B1 (ko)
IL (1) IL68228A (ko)
MX (1) MX7122E (ko)
PT (1) PT76614B (ko)
YU (1) YU91483A (ko)
ZA (1) ZA832203B (ko)

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Publication number Priority date Publication date Assignee Title
ATE25255T1 (de) * 1983-05-05 1987-02-15 Heumann Ludwig & Co Gmbh Pyrimidin-thioalkylpyridin-derivate, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel.
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
RU2006106920A (ru) 2003-08-06 2007-09-20 Синомикс Инк. (Us) Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
TW200638882A (en) * 2005-02-04 2006-11-16 Senomyx Inc Molecules comprising linked organic moieties as flavor modifiers for comestible compositions
CA2597134C (en) * 2005-02-04 2015-05-26 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS

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GB1239017A (ko) * 1968-02-22 1971-07-14
GB1234058A (ko) * 1968-10-21 1971-06-03
GB1406882A (en) * 1972-04-28 1975-09-17 Leo Pharm Prod Ltd Benzoic acid derivatives and benzisptjoaup'e 1.1 dopxode derovatoves
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GB2038825B (en) * 1978-12-16 1983-02-09 Wyeth John & Brother Ltd Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups
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Also Published As

Publication number Publication date
DE3216843C2 (de) 1986-10-23
IL68228A0 (en) 1983-06-15
DD208801A5 (de) 1984-04-11
ES520774A0 (es) 1984-01-01
ATE32894T1 (de) 1988-03-15
US4866066A (en) 1989-09-12
DK188183A (da) 1983-11-06
DK188183D0 (da) 1983-04-27
US4810715A (en) 1989-03-07
CA1213279A (en) 1986-10-28
EP0093252A2 (de) 1983-11-09
EP0093252A3 (en) 1984-08-22
KR860001578B1 (ko) 1986-10-10
MX7122E (es) 1987-06-29
IE830976L (en) 1983-11-05
PT76614A (de) 1983-05-01
DE3216843A1 (de) 1983-11-17
PT76614B (de) 1986-01-17
ES8401755A1 (es) 1984-01-01
DE3375917D1 (en) 1988-04-14
HU189272B (en) 1986-06-30
JPS58203965A (ja) 1983-11-28
AU565518B2 (en) 1987-09-17
YU91483A (en) 1986-02-28
DK160500B (da) 1991-03-18
IE55263B1 (en) 1990-07-18
DK160500C (da) 1991-08-26
ZA832203B (en) 1983-12-28
AU1264883A (en) 1983-11-10
IL68228A (en) 1987-12-20
GR78961B (ko) 1984-10-02
EP0093252B1 (de) 1988-03-09

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