KR850004477A - 2-(1-이미다졸릴)-에탄올 유도체의 제조방법 - Google Patents
2-(1-이미다졸릴)-에탄올 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850004477A KR850004477A KR1019840008011A KR840008011A KR850004477A KR 850004477 A KR850004477 A KR 850004477A KR 1019840008011 A KR1019840008011 A KR 1019840008011A KR 840008011 A KR840008011 A KR 840008011A KR 850004477 A KR850004477 A KR 850004477A
- Authority
- KR
- South Korea
- Prior art keywords
- imidazolyl
- acid addition
- acceptable acid
- physiologically acceptable
- ethanol
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- AMSDWLOANMAILF-UHFFFAOYSA-N 2-imidazol-1-ylethanol Chemical class OCCN1C=CN=C1 AMSDWLOANMAILF-UHFFFAOYSA-N 0.000 title claims 2
- 239000002253 acid Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- -1 1-imidazolyl Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- DCNRFMPQEQWLMY-UHFFFAOYSA-N 2-imidazol-1-yl-1-pyridin-2-yl-1-thiophen-2-ylethanol Chemical compound C=1C=CSC=1C(C=1N=CC=CC=1)(O)CN1C=CN=C1 DCNRFMPQEQWLMY-UHFFFAOYSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000002642 lithium compounds Chemical class 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002524 organometallic group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식(Ⅱ)의 2―(1―이미다졸릴)―에탄온올, A가 피리딜일 경우에는 페닐 또는 티에닐 마그네슘할라리드와 같은 유기금속 시약과 반응시키고, A가 그룹 R2일 경우에는 피리딜마그네슘 할라이드 또는 상응하는 리튬 화합물과 반응시키거나; 일반식(Ⅲ)의 이미다졸을 일반식(Ⅳ)의 옥시란과 반응시키고; 경우에 따라, 생성된 일반식(Ⅰ)의 화합물을 생리학적으로 허용되는 산부가염으로 전환시킴을 특징으로 하여, 일반식(Ⅰ)의 2―(1―이미다졸릴)―에탄올 유도체 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.상기식에서, R1은 수소, 탄소수 1내지 3의 알킬 그룹 또는 할로겐원자이며, R2는 그룹또는이고,R3는 수소 또는 메틸그룹이며, R4는 수소, 탄소수 1내지 3의 알킬그룹 또는 할로겐 원자이고, R5는 수소 탄소수 1내지 3의 알킬 또는 알콕시 그룹, 할로겐원자 또는 트리플루오로메틸 그룹이며, m은 1또는 2이고 A는 그룹또는 R2이다
- 제1항에 있어서, R3가 수소인 일반식(Ⅰ)의 화합물 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
- 제1항에 있어서, 2―(1―이미다졸릴)―1―(2―피리딜)―1―(2―티에닐)―에탄올 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
- 제1항에 있어서, 2―(1―이미다졸릴)―1―(2―피리딜)―1―[2―(5―클로로티에닐)]―에탄올 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
- 제1항에 있어서, 2―(1―이미다졸릴)―1―(2―피리딜)―1―(P―클로로페닐)―에탄올 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
- 제1항에 있어서, 2―(1―이미다졸릴)―1―(2―피리딜)―1―(P―브로모페닐)―에탄올 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.
- 제1항에 있어서, 2―(1―이미다졸릴)―1―(2―피리딜)―1―(P―톨릴)―에탄올 및 그의 생리학적으로 허용되는 산부가염을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3345813.84 | 1983-12-17 | ||
| DE19833345813 DE3345813A1 (de) | 1983-12-17 | 1983-12-17 | Neue 2-(1-imidazolyl)-ethanol-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850004477A true KR850004477A (ko) | 1985-07-15 |
Family
ID=6217323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840008011A KR850004477A (ko) | 1983-12-17 | 1984-12-15 | 2-(1-이미다졸릴)-에탄올 유도체의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0149115A3 (ko) |
| JP (1) | JPS60146889A (ko) |
| KR (1) | KR850004477A (ko) |
| AU (1) | AU3684584A (ko) |
| DD (1) | DD231353A5 (ko) |
| DE (1) | DE3345813A1 (ko) |
| DK (1) | DK590084A (ko) |
| ES (2) | ES8608509A1 (ko) |
| FI (1) | FI844951L (ko) |
| GR (1) | GR81210B (ko) |
| HU (1) | HUT37140A (ko) |
| IL (1) | IL73832A0 (ko) |
| NO (1) | NO845031L (ko) |
| PL (1) | PL250930A1 (ko) |
| PT (1) | PT79676B (ko) |
| ZA (1) | ZA849745B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3628545A1 (de) * | 1985-09-23 | 1987-04-23 | Hoechst Ag | Arylmethylazole und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| DE3707151A1 (de) * | 1987-03-06 | 1988-09-15 | Hoechst Ag | 1-(1-aryl-2-hydroxy-ethyl)-imidazole und deren salze, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US5049570A (en) * | 1990-01-23 | 1991-09-17 | Du Pont Merck Pharmaceutical Company | Pyridylphenyl nitrogen heterocycle-substituted carbinols and derivatives thereof with anti-inflammatory activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4081544A (en) * | 1975-12-04 | 1978-03-28 | Schering Corporation | Certain 2-(alpha(2-pyridyl)-benzyl)imidazolines and derivatives thereof |
| JPS58150566A (ja) * | 1982-03-03 | 1983-09-07 | Yoshitomi Pharmaceut Ind Ltd | 新規イミダゾ−ル誘導体 |
-
1983
- 1983-12-17 DE DE19833345813 patent/DE3345813A1/de not_active Withdrawn
-
1984
- 1984-12-07 GR GR81210A patent/GR81210B/el unknown
- 1984-12-08 EP EP84114975A patent/EP0149115A3/de not_active Withdrawn
- 1984-12-10 DK DK590084A patent/DK590084A/da not_active Application Discontinuation
- 1984-12-14 DD DD84270849A patent/DD231353A5/de unknown
- 1984-12-14 PL PL25093084A patent/PL250930A1/xx unknown
- 1984-12-14 PT PT79676A patent/PT79676B/pt unknown
- 1984-12-14 JP JP59263142A patent/JPS60146889A/ja active Pending
- 1984-12-14 ZA ZA849745A patent/ZA849745B/xx unknown
- 1984-12-14 FI FI844951A patent/FI844951L/fi not_active Application Discontinuation
- 1984-12-14 NO NO845031A patent/NO845031L/no unknown
- 1984-12-14 IL IL73832A patent/IL73832A0/xx unknown
- 1984-12-14 ES ES538600A patent/ES8608509A1/es not_active Expired
- 1984-12-15 KR KR1019840008011A patent/KR850004477A/ko not_active Application Discontinuation
- 1984-12-17 AU AU36845/84A patent/AU3684584A/en not_active Abandoned
- 1984-12-17 HU HU844697A patent/HUT37140A/hu unknown
-
1985
- 1985-03-04 ES ES540904A patent/ES540904A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK590084D0 (da) | 1984-12-10 |
| EP0149115A3 (de) | 1987-12-16 |
| JPS60146889A (ja) | 1985-08-02 |
| HUT37140A (en) | 1985-11-28 |
| PL250930A1 (en) | 1985-12-17 |
| IL73832A0 (en) | 1985-03-31 |
| ES8602756A1 (es) | 1985-12-01 |
| DE3345813A1 (de) | 1985-06-27 |
| DK590084A (da) | 1985-06-18 |
| FI844951A0 (fi) | 1984-12-14 |
| EP0149115A2 (de) | 1985-07-24 |
| DD231353A5 (de) | 1985-12-24 |
| ES8608509A1 (es) | 1986-06-16 |
| GR81210B (en) | 1985-04-08 |
| AU3684584A (en) | 1985-07-04 |
| PT79676A (de) | 1985-01-01 |
| ES538600A0 (es) | 1986-06-16 |
| PT79676B (de) | 1986-12-10 |
| ES540904A0 (es) | 1985-12-01 |
| FI844951L (fi) | 1985-06-18 |
| NO845031L (no) | 1985-06-18 |
| ZA849745B (en) | 1986-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |