KR830003475A - 신규의 피리미돈류의 제조방법 - Google Patents
신규의 피리미돈류의 제조방법 Download PDFInfo
- Publication number
- KR830003475A KR830003475A KR1019800003257A KR800003257A KR830003475A KR 830003475 A KR830003475 A KR 830003475A KR 1019800003257 A KR1019800003257 A KR 1019800003257A KR 800003257 A KR800003257 A KR 800003257A KR 830003475 A KR830003475 A KR 830003475A
- Authority
- KR
- South Korea
- Prior art keywords
- alkoxy
- formula
- methyl
- alkyl
- group
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title claims 2
- 150000008318 pyrimidones Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- -1 amino, phenoxy Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- CORCSBUUHIYAOL-UHFFFAOYSA-N 2-[2-[(5-methyl-1h-imidazol-4-yl)methylsulfanyl]ethylamino]-5-(pyridin-3-ylmethyl)-1h-pyrimidin-6-one Chemical compound N1C=NC(CSCCNC=2NC(=O)C(CC=3C=NC=CC=3)=CN=2)=C1C CORCSBUUHIYAOL-UHFFFAOYSA-N 0.000 claims 1
- JJGIHBJLNFAPHS-UHFFFAOYSA-N 5-[(3-methoxyphenyl)methyl]-2-[2-[(5-methyl-1h-imidazol-4-yl)methylsulfanyl]ethylamino]-1h-pyrimidin-6-one Chemical group COC1=CC=CC(CC=2C(NC(NCCSCC3=C(NC=N3)C)=NC=2)=O)=C1 JJGIHBJLNFAPHS-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- UCFFGYASXIPWPD-UHFFFAOYSA-N methyl hypochlorite Chemical compound COCl UCFFGYASXIPWPD-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002829 nitrogen Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 하기구조식(1)의 화합물의 제조공정.및 그것의 산부가염류, 윗식에서 Het는 치환물(동일하거나 서로 다를 수 있음)이하나 또는 그 이상의 C1-4알킬, 삼플루오로메틸, 할로겐, 히드록시, C1-4알콕시 또는 아미노기인 헤테로시클릭기를 함유한 임의치환된 5- 또는 6의 원소의 완전히 불포환된 질소임 ; n은 2또는 3임 ; Z는 수소 또는 C1-4알킬 ; A는 산소 또는 황으로 임의 저해된 C1-5알킬렌이며 B는 수소, 메틸, C3-6시클로알킬, 치환물(동일하거나 서로 다를수 있음)이 하나 또는 그 이상의 C1-4알킬, C1-4알콕시, 또는 수산기인 임의치환된 헤테로알릴기임 ; 또는 B는 나프틸, 5-또는 6-(2,3-디히드로-1,4-벤조디옥시닐)또는 4-또는 5-(1,3-벤조디옥실릴)기 또는 치환물 (동일하거나 서로 다를 수 있음)이 하나 또는 그 이상의 C1-4알킬, C1-4알콕시, 할로겐, 알릴-(C1-4알콕시), 수산, C1-4알콕시-C1-4알콕시, 삼플루오로메틸, 디(C1-4알킬)아미노, 페녹시, 할로페녹시, 또는 하기구조식(4)로 특징지어진 C1-4알콕시 페닐기인 임의치환된 페닐기임 : -Het-CH2L(4) (4)또는 Het는 반응을 저해하는 어떠한 치환물도 저해되었다는 가정하에 구조식(1)에서 정의한 대로이며 L은 티올과 대치할 수 있는 기인 하기구조식(5)의 화합물과 반응한 그것의 산부가염 : -또는 n, Z, A 및 B는 B내의 어떠한 페놀수산기도 임의로 저해되었고, 그후 저해기를 제거하고 이생산물을 부가염으로 전화시켰다는 가정하에서 구조식(1)에 정의한 대로인 그것의 산부가염.
- L이 수산, 아세톡시, 메탄설포닐옥시, P-톨루엔설포닐 옥시, 메톡시, 염소, 브롬, 또는 트리페닐포스포늄인데에 특징이 있는 청구범위 10에 청구한대로의 공정.
- L이 수산 또는 C1-4알콕시 및 반응이 산성조건하에 수행되는데에 특징이 있는 청구범위 1또는 청구범위 2에 청구된 대로의 공정.
- Het 또는 B가 산변화성, L이 염소 또는 브롬이고, 반응이 염기의 존재하에 수행되는데에 특징이 있는 청구범위 1또는 청구범위 2에 청구된대로의 공정.
- 생산물이 2-[2-(5-메틸-4-이미다졸릴메틸티오)에틸아미노]-5-(3-메톡시벤질)-4-피리미돈, 2-[2-(5-메틸-4-이미다졸릴메틸티오)에틸아미노]-5-[5-(1,3-벤조디옥솔릴메틸)-4-피리미돈 및 2-[2-(5-메틸-4-이미다졸릴 메틸티오)에틸아미노]-5-(3-피리딜메틸)-4-피리미돈 및 2-[2-(5-메틸-4-이미다졸릴 메틸티오)에틸아미노]-5-(6-메틸-3-피리딜메틸)-4-피리미돈인 데에 특징이있는 청구범위 1 또는 청구범위 2에 청구된대로의 공정.
- 반응이 산성미디엄에서 수행되며 구조식(5)의 화합물이 하기의 구조식(5나)의 화합물로부터 그 자체내에서 생성되는데에 특징이있는 청구범위 1에서 3 및 5중 어느것에 청구된 대로의 공정 :윗식에서 n, Z, A 및 B는 구조식(1)에서 정의한 대로이며 G'는 산변화성-저해기임.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7929012 | 1979-08-21 | ||
| GB7929012 | 1979-08-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830003475A true KR830003475A (ko) | 1983-06-20 |
| KR840002174B1 KR840002174B1 (ko) | 1984-11-26 |
Family
ID=10507322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800003257A KR840002174B1 (ko) | 1979-08-21 | 1980-08-19 | 신규의 피리미돈류의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0024873A1 (ko) |
| JP (1) | JPS5630975A (ko) |
| KR (1) | KR840002174B1 (ko) |
| CA (1) | CA1140129A (ko) |
| HU (1) | HU184816B (ko) |
| IL (1) | IL60862A0 (ko) |
| YU (1) | YU210180A (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4439609A (en) * | 1980-10-01 | 1984-03-27 | Smith Kline & French Laboratories Limited | Pyridines |
| ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
| US4352933A (en) * | 1981-02-06 | 1982-10-05 | Smithkline Beckman Corporation | Chemical methods and intermediates for preparing substituted pyrimidinones |
| ATE21901T1 (de) * | 1982-07-30 | 1986-09-15 | Smith Kline French Lab | Aminopyrimidinone und ihre herstellung. |
| US4772704A (en) * | 1983-09-21 | 1988-09-20 | Bristol-Myers Company | 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity |
| JP2003019317A (ja) * | 2001-07-06 | 2003-01-21 | Toyomaru Industry Co Ltd | 遊技機 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL57005A (en) * | 1978-04-11 | 1983-11-30 | Smith Kline French Lab | Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor |
| US4496567A (en) * | 1978-11-13 | 1985-01-29 | Smith Kline & French Laboratories Limited | Phenyl alkylaminopyrimidones |
-
1980
- 1980-08-05 CA CA000357601A patent/CA1140129A/en not_active Expired
- 1980-08-18 JP JP11393280A patent/JPS5630975A/ja active Pending
- 1980-08-19 IL IL60862A patent/IL60862A0/xx unknown
- 1980-08-19 EP EP80302864A patent/EP0024873A1/en not_active Withdrawn
- 1980-08-19 KR KR1019800003257A patent/KR840002174B1/ko active IP Right Grant
- 1980-08-19 HU HU80269A patent/HU184816B/hu unknown
- 1980-08-21 YU YU02101/80A patent/YU210180A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0024873A1 (en) | 1981-03-11 |
| YU210180A (en) | 1983-06-30 |
| HU184816B (en) | 1984-10-29 |
| IL60862A0 (en) | 1980-10-26 |
| CA1140129A (en) | 1983-01-25 |
| JPS5630975A (en) | 1981-03-28 |
| KR840002174B1 (ko) | 1984-11-26 |
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