KR840000475A - 염화카르니틴의 제조방법 - Google Patents
염화카르니틴의 제조방법 Download PDFInfo
- Publication number
- KR840000475A KR840000475A KR1019820002945A KR820002945A KR840000475A KR 840000475 A KR840000475 A KR 840000475A KR 1019820002945 A KR1019820002945 A KR 1019820002945A KR 820002945 A KR820002945 A KR 820002945A KR 840000475 A KR840000475 A KR 840000475A
- Authority
- KR
- South Korea
- Prior art keywords
- carnitine
- carnitine chloride
- chloride
- hours
- preparing
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 title 1
- 229960000678 carnitine chloride Drugs 0.000 title 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims 3
- 229960004203 carnitine Drugs 0.000 claims 3
- 239000012320 chlorinating reagent Substances 0.000 claims 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- HKYGSMOFSFOEIP-UHFFFAOYSA-N dichloro(dichloromethoxy)methane Chemical compound ClC(Cl)OC(Cl)Cl HKYGSMOFSFOEIP-UHFFFAOYSA-N 0.000 claims 1
- 230000035484 reaction time Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 실온에서 약 1.5시간 내지 12시간 사이의 반응시간 동안 카르니틴을 염화티오닐, 디클로로메틸에테르 및 염화옥살릴 중에서 선택한 염소화제로 염소화하는 공정을 특징으로 하는 카르니틴 산염화물 제조방법.
- 청구범위 제1항에 있어서 카르니틴/염소화제의 몰비가 1 : 1 내지 1 : 3 사이인 것.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48817/81A IT1171360B (it) | 1981-07-03 | 1981-07-03 | Procedimento per la preparazione del cloruro acido di carnitina |
IT48817A/81 | 1981-07-03 | ||
IT48817 | 1981-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840000475A true KR840000475A (ko) | 1984-02-22 |
KR860001886B1 KR860001886B1 (ko) | 1986-10-24 |
Family
ID=11268676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8202945A KR860001886B1 (ko) | 1981-07-03 | 1982-07-01 | 염화카르니틴의 제조방법 |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5815943A (ko) |
KR (1) | KR860001886B1 (ko) |
AT (1) | AT390057B (ko) |
BE (1) | BE893713A (ko) |
CA (1) | CA1186332A (ko) |
CH (1) | CH648546A5 (ko) |
DE (1) | DE3224666A1 (ko) |
DK (1) | DK154425C (ko) |
ES (1) | ES513658A0 (ko) |
FR (1) | FR2510559B1 (ko) |
GB (1) | GB2101133B (ko) |
GR (1) | GR76546B (ko) |
IE (1) | IE53279B1 (ko) |
IL (1) | IL66251A0 (ko) |
IT (1) | IT1171360B (ko) |
LU (1) | LU84244A1 (ko) |
NL (1) | NL189666C (ko) |
SE (1) | SE448724B (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1190358B (it) * | 1985-05-24 | 1988-02-16 | Sclavo Spa | Procedimento per la preparazione di l-carnitina |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3940439A (en) * | 1973-11-14 | 1976-02-24 | G. D. Searle & Co. | Acid chloride synthesis |
IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
DE2943433A1 (de) * | 1979-10-26 | 1981-05-07 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von carbonsaeurehalogeniden |
-
1981
- 1981-07-03 IT IT48817/81A patent/IT1171360B/it active
-
1982
- 1982-06-24 CH CH3884/82A patent/CH648546A5/it not_active IP Right Cessation
- 1982-06-25 IE IE1524/82A patent/IE53279B1/en not_active IP Right Cessation
- 1982-06-29 GB GB08218824A patent/GB2101133B/en not_active Expired
- 1982-06-30 DK DK295482A patent/DK154425C/da not_active IP Right Cessation
- 1982-06-30 BE BE0/208502A patent/BE893713A/fr not_active IP Right Cessation
- 1982-06-30 LU LU84244A patent/LU84244A1/fr unknown
- 1982-06-30 CA CA000406463A patent/CA1186332A/en not_active Expired
- 1982-07-01 KR KR8202945A patent/KR860001886B1/ko active
- 1982-07-01 GR GR68615A patent/GR76546B/el unknown
- 1982-07-01 DE DE19823224666 patent/DE3224666A1/de active Granted
- 1982-07-02 AT AT0257382A patent/AT390057B/de not_active IP Right Cessation
- 1982-07-02 SE SE8204117A patent/SE448724B/sv not_active IP Right Cessation
- 1982-07-02 JP JP57116084A patent/JPS5815943A/ja active Granted
- 1982-07-02 ES ES513658A patent/ES513658A0/es active Granted
- 1982-07-02 FR FR8211685A patent/FR2510559B1/fr not_active Expired
- 1982-07-02 NL NLAANVRAGE8202677,A patent/NL189666C/xx not_active IP Right Cessation
- 1982-07-07 IL IL66251A patent/IL66251A0/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8204117D0 (sv) | 1982-07-02 |
GB2101133B (en) | 1985-08-14 |
ES8304064A1 (es) | 1983-03-01 |
NL189666C (nl) | 1993-06-16 |
NL8202677A (nl) | 1983-02-01 |
LU84244A1 (fr) | 1983-01-20 |
ATA257382A (de) | 1989-08-15 |
JPH0244300B2 (ko) | 1990-10-03 |
IL66251A0 (en) | 1982-11-30 |
BE893713A (fr) | 1982-10-18 |
ES513658A0 (es) | 1983-03-01 |
FR2510559B1 (fr) | 1986-05-09 |
AT390057B (de) | 1990-03-12 |
IT1171360B (it) | 1987-06-10 |
KR860001886B1 (ko) | 1986-10-24 |
DK154425B (da) | 1988-11-14 |
GR76546B (ko) | 1984-08-10 |
IT8148817A0 (it) | 1981-07-03 |
CA1186332A (en) | 1985-04-30 |
CH648546A5 (it) | 1985-03-29 |
DK154425C (da) | 1989-04-10 |
DE3224666A1 (de) | 1983-01-20 |
JPS5815943A (ja) | 1983-01-29 |
SE8204117L (sv) | 1983-01-04 |
IE821524L (en) | 1983-01-03 |
DK295482A (da) | 1983-01-04 |
SE448724B (sv) | 1987-03-16 |
IE53279B1 (en) | 1988-09-28 |
GB2101133A (en) | 1983-01-12 |
DE3224666C2 (ko) | 1991-01-24 |
FR2510559A1 (fr) | 1983-02-04 |
NL189666B (nl) | 1993-01-18 |
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